The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis

Biomaterials

Volumn 33, Issue 18, 2012, Pages 4555-4564

  Austin, James W ^a,c,f   Kang, Catherine E ^a,b,d   Baumann, M Douglas ^a,b,d   DiDiodato, Lisa ^e,g   Satkunendrarajah, Kajana ^c,f   Wilson, Jefferson R ^b   Stanisz, Greg J ^e   Shoichet, Molly S ^a,b,d   Fehlings, Michael G ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f TORONTO WESTERN HOSPITAL   (Canada)

^g Toronto Medical Discovery   (Canada)

Author keywords

Fibrosis; Hyaluronan; Hydrogel; Inflammation; Spinal cord injury

Indexed keywords

CYTOKINES; FIBROSIS; FLUID-FILLED CAVITY; FUNCTIONAL RECOVERY; HETEROGENEOUS CONDITIONS; HYALURONAN; INFLAMMATION; INTRATHECAL; MECHANICAL FORCE; METHYL CELLULOSE; RAT MODEL; RODENT MODELS; SCAR FORMATION; SPINAL CORD INJURIES (SCI); SPINAL CORDS; SUBARACHNOID SPACES;

DAMAGE DETECTION; HYDROGELS; MOLECULAR BIOLOGY; PATHOLOGY; PATIENT TREATMENT;

PATIENT REHABILITATION;

HYALURONIC ACID; INTERLEUKIN 1ALPHA; METHYLCELLULOSE;

ANIMAL MODEL; ANIMAL TISSUE; ARACHNOIDITIS; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECT; FEMALE; FIBROSIS; HYDROGEL; MORPHOMETRICS; NERVE CONDUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POST TRAUMATIC SYRINGOMYELIA; PRIORITY JOURNAL; RAT; SCAR FORMATION; SPINAL CORD INJURY; SUBARACHNOID SPACE; SYRINGOMYELIA;

ANIMALS; ARACHNOIDITIS; ELECTROPHYSIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSIS; HYALURONIC ACID; HYDROGEL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INJECTIONS, SPINAL; MAGNETIC RESONANCE IMAGING; RATS; RATS, WISTAR; SPINAL CORD INJURIES;

RATTUS; RODENTIA;

EID: 84862819061     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.03.022     Document Type: Article

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