Cyclosporin a enhances cell survival in neural precursor populations in the adult central nervous system

Molecular and Cellular Pharmacology

Volumn 2, Issue 3, 2010, Pages 81-88

  Hunt, Jessica ^a   Morshead, Cindi ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adhesion; Cyclosporin A; Neural precursor cells; Survival

Indexed keywords

CYCLOSPORIN A;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL FATE; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PROGENY; RAT; REGENERATIVE MEDICINE; TISSUE REGENERATION; TISSUE REPAIR;

EID: 77954304964     PISSN: None     EISSN: 19381247     Source Type: Journal    
DOI: 10.4255/mcpharmacol.10.11     Document Type: Article

References (53)

1. Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 1976;6:465-478.
2. Borel JF, Feurer C, Magnee C, Stahelin H. Effects of the new anti-lymphocytic peptide cyclosporine A in animals. Immunology 1977;32:1017-1025.
3. Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW. Cyclophilin: A specific cytosolic binding protein for Cyclosporin A. Science 1984;226:544-547.
4. Fischer G, Wittmann-Liebold B, Lang K, Kiefhaber T, Schmid FX. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 1989;337:476-488.
5. Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the Cyclosporin A-binding protein cyclophilin. Nature 1989;337:473-485.
6. Wang P, Heitman J. The cyclophilins. Genome Bio 2005;6:226-231.
7. Griffith JP, Kim JL, Kim EE, et al. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 1995;82:507-522.
8. Kissinger CR, Parge HE, Knighton DR, et al. Crystal structure of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature 1995;378:641-644.
9. Kay JE, Benzie CR, Borghetti AF. Effects of Cyclosporin A on lymphocyte activation by the calcium ionophore A23187. Immunology 1983;50:441-456.
10. Flanagan WF, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991;352:803-807.
11. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T-lymphocytes is inhibited by FK-506 and cyclosporin A. PNAS 1992;89:3686-3690.
12. Scheff SW, Sullivan PG. Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents. J Neurotrauma 1999;16:783-792.
13. Ibarra A, Correa D, Willms K, et al. Effects of cyclosporin A on immune response, tissue protection, and motor function of rats subjected to spinal cord injury. Brain Res 2003;979:165-178.
14. Kaminska B, Gaweda-Walerych K, Zawadzka M. Molecular mechanisms of neuroprotective action of immunosuppressants - facts and hypotheses. J Cell Mol Med 2004;8:45-58.
15. Erlandsson A, Morshead CM. Exploiting the properties of adult neural stem cell for the treatment of disease. Curr Opin Mol Ther 2006;8:331-347.
16. Morshead CM, Reynolds BA, Craig CG, et al. Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cell. Neuron 1994;13:1071-1082.
17. Lois C, Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science 1994;264:1145-1158.
18. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-1710.
19. Gage FH. Mammalian neural stem cells. Science 2000;287:1433-1448.
20. Aarum J, Sandberg K, Haeberlein SLB, Persson MAA. Migration and differentiation of neural precursor cells can be directed by microglia. PNAS 2003;100:15983-15988.
21. Ben-Hur T, Ben-Menachem OB, Furer V, et al. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol Cell Neurosci 2003;24:623-631.
22. Butovsky O, Ziv Y, Schwartz A, et al. Microglia activated by IL-4 or INF-y differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 2006;31:149-160.
23. Pluchino S, Martino G. Neural stem cell-mediated immunomodulation: Repairing the haemorrhagic brain. Brain 2008;131:604-615.
24. Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 1996;16:7599-7609.
25. Coles-Takabe BLK, Brain I, Purpura KA, et al. Don't look: Growing clonal versus nonclonal neural stem cell colonies. Stem cells 2008;26:2938-2944.
26. Hunt J, Cheng A, Hoyles A, Jervis E, Morshead C. Cyclosporin A has direct effects on adult neural precursor cells. J Neurosci 2010;30:2888-2896.
27. Gritti A, Bonfanti L, Doetsch F, et al. Multipotent neural stem cells reside in the rostral extension and olfactory bulb of adult rodents. J Neurosci 2002;22:437-445.
28. Tropepe V, Coles BL, Chiasson BJ, et al. Retinal stem cells in the adult mammalian eye. Science 2000;287:2032-2046.
29. Johansson CB, Momma S, Clarke DL, et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999;96:25-34.
30. Martens DJ, Seaberg RM, van der Kooy D. In vivo infusion of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord. Eur J Neurosci 2002;16:1045-1057.
31. Mothe AJ, Tator CH. Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat. Neurosci 2005;131:177-187.
32. Hitoshi S, Tropepe V, Ekker M, van der Kooy D. Neural stem cell lineages are regionally specified, but not committed within distinct compartments of the developing brain. Development 2002;129:233-244.
33. Zappone MV, Galli R, Catena R, et al. Sox 2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development 2000;127: 2367-2382.
34. Kim H, Kim I, Lee I, Lee J, Snyder EY. Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but not committed. Exp Neurol 2006;199:222-235.
35. He W, Ingraham C, Rising L, Goderie S, Temple S. Multipotent stem cells from the mouse basal forebrain contribute GABAergic neurons and oligodendrocytes to the cerebral cortex during embryogenesis. J Neurosci 2001;21:8854-8862.
36. Shihabuddin LS, Ray J, Gage FH. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. Exp Neurol 1997;148:577-586.
37. Gabay L, Lowell S, Rubin LL, Anderson DJ. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron 2003;40:485-499.
38. Marmarou CR, Povlishock JT. Administration of the immunophilin ligand FK506 differentially attenuates neurofilament compaction and impaired axonal transport in injured axons following diffuse traumatic brain injury. Exp Neurol 2005;197: 353-362.
39. Reeves TM, Phillips LL, Lee NN, Povlishock JT. Preferential neuroprotective effect of tacrolimus (FK506) on unmyelinated axons following traumatic brain injury. Brain Res 2007;1154:225-236.
40. Singleton RH, Stone JR, Okonkwo DO, Pellicane AJ, Povlishock JT. The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury. J Neurotrauma 2001;18:607-614.
41. Heales SJR, Bolanos JP, Steward VC, et al. Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta 1999;1410:215-228.
42. Nakamura T, Lipton SA. S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death Differ 2007;14:1305-1314.
43. Deng Y, Thompson BM, Gao X, Hall ED. Temporal relationship of peroxynitrate-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury. Exp Neurol 2007;205:154-165.
44. Mbye LH, Singh IN, Carrico KM, Saatman KE, Hall ED. Comparative neuroprotective effects of cyclosporin A and NIM811, a non-immunosuppressive cyclosporin A analog, following traumatic brain injury. J Cereb Blood Flow Metab 2009;29:87-97.
45. Schreiber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991;251:283-297.
46. Snyder SH, Lai MM, Burnett PE. Immunophilins in the nervous system. Neuron 1998;21:283-294.
47. Barik S. Immunophilins: For the love of proteins. Cell Mol Life Sci 2006;63:2889-2900.
48. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal cell death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995;15:961-973.
49. Petit PX, Zamzami N, Vayssiere JL, et al. Implication of mitochondria in apoptosis. Mol Cell Biochem 1997;174:185-198.
50. Okonkwo DO, Povlishock JT. An intrathecal bolus of Cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury. J Cereb Blood Flow Metab 1999;19:443-451.
51. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. J Biochem 1990;268:153-160.
52. Zoratti M, Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1995;1241:139-176.
53. Baines CP, Kaiser RA, Purcell NH, et al. Loss of cyclophilin D reveals a critical role for mitochondrail permeability transition in cell death. Nature 2005;434:658-662.