A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 197-202

  Caicco, Matthew J ^a,b   Cooke, Michael J ^a   Wang, Yuanfei ^a,b   Tuladhar, Anup ^b   Morshead, Cindi M ^a,b   Shoichet, Molly S ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cyclosporin A; Drug delivery; Hyaluronan; Methylcellulose; Poly(lactide co glycolide); Stroke

Indexed keywords

CYCLOSPORIN A; HYALURONAN; METHYLCELLULOSE; POLY LACTIDE-CO-GLYCOLIDE; STROKE;

BRAIN; COPOLYMERS; DRUG DELIVERY; HYALURONIC ACID; STEM CELLS;

HYDROGELS;

CYCLOSPORIN A; DRUG CARRIER; HYALURONAN METHYLCELLULOSE; MICROSPHERE; POLYGLACTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROVASCULAR ACCIDENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISPERSION; DRUG ACTIVITY; DRUG ADMINISTRATION; DRUG BRAIN LEVEL; DRUG DELIVERY DEVICE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SOLUBILITY; ENCAPSULATION; EPICORTICAL DRUG ADMINISTRATION; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ANIMALS; BRAIN; CHROMATOGRAPHY, LIQUID; CYCLOSPORINE; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HYALURONIC ACID; HYDROGELS; LACTIC ACID; METHYLCELLULOSE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MODELS, BIOLOGICAL; NEURAL STEM CELLS; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLUBILITY; STROKE; SURFACE PROPERTIES; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84873432184     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.002     Document Type: Article

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