Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain

Biomaterials

Volumn 32, Issue 24, 2011, Pages 5688-5697

  Cooke, Michael J ^a   Wang, Yuanfei ^a,b   Morshead, Cindi M ^b,c   Shoichet, Molly S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Drug delivery ; Epidermal growth factor; Hydrogel; Poly(ethylene glycol); Stroke; Tissue penetration

Indexed keywords

CENTRAL NERVOUS SYSTEMS; DELIVERY SYSTEMS; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTORS; GROWTH FACTOR; HYALURONAN; INVASIVENESS; LOCAL DELIVERY; METHYLCELLULOSE; MOUSE BRAIN; PROTEIN ACCUMULATION; STROKE; TISSUE DAMAGE; TISSUE REGENERATION;

BRAIN; CELL PROLIFERATION; ETHYLENE; ETHYLENE GLYCOL; HYDROGELS; PEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; STEM CELLS; TISSUE;

CONTROLLED DRUG DELIVERY;

HYALURONIC ACID; KI 67 ANTIGEN; MACROGOL; METHYLCELLULOSE; NESTIN; PROTEINASE; RECOMBINANT EPIDERMAL GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CELL PROLIFERATION; CONTROLLED DRUG RELEASE; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG STABILITY; EXTRACELLULAR SPACE; HYDROGEL; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STROKE;

ANIMALS; BRAIN; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; HYALURONIC ACID; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NEURAL STEM CELLS; PEPTIDE HYDROLASES; POLYETHYLENE GLYCOLS; STROKE;

EID: 79957888589     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.032     Document Type: Article

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