Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance

Kidney International

Volumn 88, Issue 2, 2015, Pages 286-298

  Sun, Yu B Y ^a   Qu, Xinli ^a   Howard, Victor ^a   Dai, Lie ^b   Jiang, Xiaoyun ^b   Ren, Yi ^c   Fu, Ping ^d   Puelles, Victor G ^a   Nikolic Paterson, David J ^e   Caruana, Georgina ^a   Bertram, John F ^a   Sleeman, Mark W ^a   Li, Jinhua ^a  

^a MONASH UNIVERSITY   (Australia)

^b SUN YAT SEN UNIVERSITY   (China)

^c FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d SICHUAN UNIVERSITY   (China)

^e SOUTHERN HEALTH   (Australia)

Author keywords

mitochondrial injury; obesity related renal disease; podocyte injury; Smad3 phosphorylation; TGF 1

Indexed keywords

NEPHRIN; SMAD3 PROTEIN; SYNAPTOPODIN; 6,7-DIMETHYL-2-(2E)-3-(1-METHYL-2-PHENYL-1H-PYRROLO(2,3-B)PYRIDIN-3-YL-PROP-2-ENOYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE; ACTIN BINDING PROTEIN; ENZYME INHIBITOR; FAT INTAKE; FLAVONOID; FLAVOPIRIDOL; INSULIN; ISOQUINOLINE DERIVATIVE; PALMITIC ACID; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SMAD3 PROTEIN, MOUSE; SYNPO PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; CELL DAMAGE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; KIDNEY FIBROSIS; LIPID DIET; MOUSE; NONHUMAN; OBESITY; OBESITY RELATED RENAL DISEASE; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEINURIA; SIGNAL TRANSDUCTION; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPLICATION; DEFICIENCY; DRUG EFFECTS; FAT INTAKE; FIBROSIS; GENE SILENCING; GENETICS; MALE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; PROTECTION;

ANIMALS; CELLS, CULTURED; DIETARY FATS; ENZYME INHIBITORS; FIBROSIS; FLAVONOIDS; GENE KNOCKDOWN TECHNIQUES; INSULIN; INSULIN RESISTANCE; ISOQUINOLINES; MALE; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MITOCHONDRIA; OBESITY; PALMITIC ACID; PHOSPHORYLATION; PIPERIDINES; PODOCYTES; PROTECTIVE FACTORS; PROTEIN KINASE INHIBITORS; PYRIDINES; PYRROLES; SIGNAL TRANSDUCTION; SMAD3 PROTEIN;

EID: 84938547225     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.121     Document Type: Article

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