Interference with TGF-β signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 5, 2007, Pages

  Wang, Amy ^a   Ziyadeh, Fuad N ^b   Eun, Young Lee ^a,c   Pyagay, Petr E ^a   Sun, Hee Sung ^d   Sheardown, Steven A ^e   Laping, Nicholas J ^e   Chen, Sheldon ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c Soonchunhyang University College of Medicine   (South Korea)

^d Mokdong Hospital   (South Korea)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Glomerular basement membrane thickening; Mesangial matrix expansion; Podocyte slit pore density; Streptozotocin; Vascular endothelial growth factor

Indexed keywords

CREATININE; NITROGEN; SMAD3 PROTEIN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA; UREA;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; GLOMERULUS BASEMENT MEMBRANE; KIDNEY HYPERTROPHY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UREA NITROGEN BLOOD LEVEL;

EID: 36048950801     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00274.2007     Document Type: Article

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