CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

Molecular Therapy

Volumn 23, Issue 8, 2015, Pages 1308-1319

  Lipinski, Daniel M ^a,b,c   Barnard, Alun R ^a,b   Singh, Mandeep S ^a,b   Martin, Chris ^d   Lee, Edward J ^e   Davies, Wayne I L ^a,f   MacLaren, Robert E ^a,b,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e MOORFIELDS EYE HOSPITAL   (United Kingdom)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; PARVOVIRUS VECTOR; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL SURVIVAL; CONTROLLED STUDY; EVOKED VISUAL RESPONSE; EXTRACELLULAR MATRIX; MOUSE; NEUROPROTECTION; NONHUMAN; PHOTORECEPTOR; PROTEIN ANALYSIS; PROTEIN DEGRADATION; RETINA CONE; RETINA IMAGE; RETINITIS PIGMENTOSA; UPREGULATION; VIRAL GENE THERAPY; VISUAL CORTEX; ANIMAL; C57BL MOUSE; DISEASE COURSE; DISEASE MODEL; ELECTROPHYSIOLOGY; ELECTRORETINOGRAPHY; EYE FUNDUS; FLUORESCENCE MICROSCOPY; GENE THERAPY; GENE VECTOR; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; RETINA; SEQUENCE ANALYSIS; TREATMENT OUTCOME;

MURINAE;

ANIMALS; CILIARY NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELECTROPHYSIOLOGY; ELECTRORETINOGRAPHY; EXTRACELLULAR MATRIX; FUNDUS OCULI; GENETIC THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; NEUROPROTECTION; RETINA; RETINAL CONE PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME; TREATMENT OUTCOME; VISUAL CORTEX;

EID: 84938420570     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.68     Document Type: Article

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