Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 51, 2014, Pages E5574-E5583

  Gaub, Benjamin M ^a   Berry, Michael H ^a   Holt, Amy E ^a   Reiner, Andreas ^a   Kienzler, Michael A ^a   Dolgova, Natalia ^b   Nikonov, Sergei ^c   Aguirre, Gustavo D ^b   Beltran, William A ^b   Flannery, John G ^a   Isacoff, Ehud Y ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Azobenzene photoswitches; Optogenetic pharmacology; Retinal gene therapy; Retinitis pigmentosa; Visual prosthetics

Indexed keywords

AZOBENZENE; GLUTAMIC ACID; ION CHANNEL; IONOTROPIC RECEPTOR; LIGHT GATED IONOTROPIC GLUTAMATE RECEPTOR; MALEIMIDE; MALEIMIDE AZOBENZENE GLUTAMATE 0 WITH PEAK EFFICIENCY AT 460 NM; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATIVE LEARNING TEST; AVOIDANCE BEHAVIOR; BLINDNESS; CANINE MODEL; CONTROLLED STUDY; CONVALESCENCE; ELECTRODE; EMBRYO; EXPLANT; GENE EXPRESSION; GENE SWITCHING; GENE TARGETING; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGHT; LIGHT INTENSITY; MOUSE; NONHUMAN; PATTERN RECOGNITION; PHOTORECEPTOR; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA DEGENERATION; RETINA DYSTROPHY; RETINA GANGLION CELL; RETINA ROD; VIRAL GENE DELIVERY SYSTEM; VISION; ANIMAL; C3H MOUSE; C57BL MOUSE; CHANNEL GATING; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIATION RESPONSE;

ANIMALIA; CANIS FAMILIARIS; MAMMALIA; MUS; RODENTIA;

ANIMALS; BLINDNESS; ION CHANNEL GATING; ION CHANNELS; LIGHT; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; RETINAL GANGLION CELLS; VISION, OCULAR;

EID: 84919919725     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414162111     Document Type: Article

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