Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats

Brain Pathology

Volumn 14, Issue 4, 2004, Pages 378-387

  Maier, Katharina ^a   Rau, Christian R ^a   Storch, Maria K ^b   Sättler, Muriel B ^a   Demmer, Iris ^a   Weissert, Robert ^c   Taheri, Naimeh ^a   Kuhnert, Antje V ^a   Bähr, Mathias ^a   Diem, Ricarda ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEIN BCL 2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ELECTRORETINOGRAM; EVOKED VISUAL RESPONSE; FEMALE; MULTIPLE SCLEROSIS; NERVE FIBER; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; OPTIC NERVE DISEASE; RAT; RETINA GANGLION CELL; SIGNAL TRANSDUCTION;

EID: 8744297398     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2004.tb00081.x     Document Type: Article

References (56)

1. Adelmann M, Wood J, Benzel I, Fiori P, Lassmann H, Matthieu JM, Gardinier MV, Dornmair K, Linington C (1995) The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat. J Neuroimmunol 63:17-27.
2. Allsopp TE, Kiselev S, Wyatt S, Davies AM (1995) Role of Bcl-2 in the brain-derived neurotrophic factor survival response. Eur J Neurosci 7:1266-1272.
3. Alonzi T, Middleton G, Wyatt S, Buchman V, Betz UA, Muller W, Musiani P, Poli V, Davies AM (2001) Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci 18:270-282.
4. Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Brück W (2000) Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 123:1174-1183.
5. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME (1997) Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278:477-483.
6. Boulton TG, Zhong Z, Wen Z, Darnell JE, Jr, Stahl N, Yancopoulos GD (1995) STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc Natl Acad Sci U S A 92:6915-6919.
7. Bredesen DE (1995) Neural apoptosis. Ann Neurol 38:839-851.
8. Cao W, Wen R, Li F, Lavail MM, Steinberg RH (1997) Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp Eye Res 65:241-248.
9. Cheng L, Hosteller KY, Chaidhawangul S, Gardner MF, Beadle JR, Toyoguchi M, Bergeron-Lynn G, Freeman WR (2002) Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O- hexadecylpropanediol-3-phospho-ganciclovir. Invest Ophthalmol Vis Sci 43:515-521.
10. Diem R, Meyer R, Weishaupt JH, Bähr M (2001) Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J Neurosci 21: 2058-2066.
11. Diem R, Hobom M, Grötsch P, Kramer B, Bähr M (2003) Interleukin-1 beta protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo. Mol Cell Neurosci 22:487-500.
12. Diem R, Hobom M, Maier K, Weissert R, Storch MK, Meyer R, Bahr M (2003) Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci 23:6993-7000.
13. Dittrich F, Thoenen H, Sendtner M (1994) Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat. Ann Neurol 35: 151-163.
14. Dolcet X, Soler RM, Gould TW, Egea J, Oppenheim RW, Comella JX (2001) Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the phosphatidylinositol 3-kinase pathway. Mol Cell Neurosci 18:619-631.
15. Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399.
16. Gan IM, van Dissel JT, Beekhuis WH, Swart W, van Meurs JC (2001) Intravitreal vancomycin and gentamicin concentrations in patients with postoperative endophthalmitis. Br J Ophthalmol 85:1289-1293.
17. Giess R, Maurer M, Linker R, Gold R, Warmuth-Metz M, Toyka KV, Sendtner M, Rieckmann P (2002) Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. Arch Neurol 59:407-409.
18. Hobom M, Storch MK, Weissert R, Maier K, Radhakrishnan A, Kramer B, Bähr M, Diem R (2004) Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol 14:148-157.
19. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336.
20. Hohlfeld R (1997) Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives. Brain 120: 865-916.
21. Ip NY, Yancopoulos GD (1996) The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 19: 491-515.
22. Isenmann S, Wahl C, Krajewski S, Reed JC, Bahr M (1997) Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat. Eur J Neurosci 9:1763-1772.
23. Johns TG, Kerlero de Rosbo N, Menon KK, Abo S, Gonzales MF, Bernard CC (1995) Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. J Immunol 154:5536-5541.
24. Ju WK, Lee MY, Hofmann HD, Kirsch M, Chun MH (1999) Expression of CNTF in Muller cells of the rat retina after pressure-induced ischemia. Neuroreport 10:419-422.
25. Kermer P, Klöcker N, Labes M, Bähr M (1998) Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 8:4656-4662.
26. Kermer P, Klöcker N, Labes M, Bähr M (2000) Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo. J Neurosci 20:2-8.
27. Kermer P, Klöcker N, Weishaupt JH, Bähr M (2001) Transection of the optic nerve in rats: studying neuronal death and survival in vivo. Brain Res Brain Res Protoc 7:255-260.
28. Kirsch M, Hofmann HD (1994) Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system. Neurosci Lett 180:163-166.
29. Kirsch M, Lee MY, Meyer V, Wiese A, Hofmann HD (1997) Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: expression of CNTF and its receptors and in vitro effects on target cells. J Neurochem 68:979-990.
30. Klöcker N, Braunling F, Isenmann S, Bähr M (1997) In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells. Neuroreport 8: 3439-3442.
31. Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H (2000) Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 157:267-276.
32. Kultz D, Burg M (1998) Evolution of osmotic stress signaling via MAP kinase cascades. J Exp Biol 201:3015-3021.
33. Lassmann H, Brück W, Lucchinetti C (2001) Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 7:115-121.
34. Linker RA, Maurer M, Gaupp S, Martini R, Holtmann B, Giess R, Rieckmann P, Lassmann H, Toyka KV, Sendtner M, Gold R (2002) CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nat Med 8:620-624.
35. Liu C, Peng M, Laties AM, Wen R (1998) Preconditioning with bright light evokes a protective response against light damage in the rat retina. J Neurosci 18:1337-1344.
36. MacLennan AJ, Vinson EN, Marks L, McLaurin DL, Pfeifer M, Lee N (1996) Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. J Neurosci 6:621-630.
37. Mattson MP (2000) Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1:120-129.
38. Mey J, Thanos S (1993) Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res 602:304-317.
39. Meyer R, Weissert R, Diem R, Storch MK, de Graaf KL, Kramer B, Bahr M (2001) Acute neuronal apoptosis in a rat model of multiple sclerosis. J Neurosci 21:6214-6220.
40. Noseworthy JH, Gold R, Hartung HP (1999) Treatment of multiple sclerosis: recent trials and future perspectives. Curr Opin Neurol 12:279-293.
41. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 144:3602-3610.
42. Peterson JW, Bo L, Mork S, Chang A, Trapp BD (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50:389-400.
43. Peterson WM, Wang Q, Tzekova R, Wiegand SJ (2000) Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 20:4081-4090.
44. Rajan P, McKay RD (1998) Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18:3620-3629.
45. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6.
46. Segal RA, Greenberg ME (1996) Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-489.
47. Sendtner M, Dittrich F, Hughes RA, Thoenen H (1994) Actions of CNTF and neurotrophins on degenerating motoneurons: preclinical studies and clinical implications. J Neurol Sci 124 Suppl: 77-83.
48. Stahl N, Yancopoulos GD (1994) The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. J Neurobiol 25:1454-1466.
49. Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE, Jr, Yancopoulos GD (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349-1353.
50. Storch MK, Stefferl A, Brehm U, Weissert R, Wallstrom E, Kerschensteiner M, Olsson T, Linington C, Lassmann H (1998) Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol 8:681-694.
51. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338: 278-285.
52. Trapp BD, Ransohoff R, Rudick R (1999) Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 12: 295-302.
53. van Adel BA, Kostic C, Deglon N, Ball AK, Arsenijevic Y (2003) Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time. Hum Gene Ther 14:103-115.
54. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-mycto immortalize pre-B cells. Nature 335:440-442.
55. Weise J, Isenmann S, Klöcker N, Kugler S, Hirsch S, Gravel C, Bahr M (2000) Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo. Neurobiol Dis 7:212-223.
56. Weissert R, Wallstrom E, Storch MK, Stefferl A, Lorentzen J, Lassmann H, Linington C, Olsson T (1998) MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest 102: 1265-1273.