Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 2633-2641

  Salomon, Johanna J ^a,e   Hagos, Yohannes ^b,c   Petzke, Sören ^b   Kühne, Annett ^c   Gausterer, Julia C ^a   Hosoya, Ken Ichi ^d   Ehrhardt, Carsten ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c PortaCellTec Biosciences GmbH   (Germany)

^d UNIVERSITY OF TOYAMA   (Japan)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

bronchodilators; competitive inhibition; inhalation biopharmaceutics; pulmonary drug disposition; respiratory epithelium

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; FORMOTEROL; ORGANIC CATION TRANSPORTER 1; SALBUTAMOL; SALMETEROL; TRITIUM; FORMOTEROL FUMARATE; SALMETEROL XINAFOATE;

ARTICLE; ASTHMA; BRONCHODILATATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DISPOSITION; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG TRANSPORT; HEK293 CELL LINE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LUNG ALVEOLUS EPITHELIUM CELL; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; METABOLISM; RESPIRATORY FUNCTION; RESPIRATORY TRACT MUCOSA; TRANSPORT AT THE CELLULAR LEVEL;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; BIOLOGICAL TRANSPORT; CELLS, CULTURED; EPITHELIAL CELLS; FORMOTEROL FUMARATE; HEK293 CELLS; HUMANS; ORGANIC CATION TRANSPORTER 1; RESPIRATORY MUCOSA; RESPIRATORY TRACT ABSORPTION; SALMETEROL XINAFOATE; TRANSFECTION;

EID: 84938335051     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500854e     Document Type: Article

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