In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice

Journal of Pharmaceutical Sciences

Volumn 102, Issue 9, 2013, Pages 3373-3381

  Nakanishi, Takeo ^a   Hasegawa, Yoshitaka ^a   Haruta, Tsunemitsu ^a   Wakayama, Tomohiko ^a   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

COPD; Epithelial; Membrane transport transporters; OCT; OCTN; Permeability; Pulmonary delivery absorption

Indexed keywords

CARNITINE; ESTRONE SULFATE; IPRATROPIUM BROMIDE; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; THIONEINE;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEK293; CHRONIC OBSTRUCTIVE LUNG DISEASE; CILIATED EPITHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; ELECTRON MICROSCOPY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRACHEOBRONCHIAL TREE;

COPD; EPITHELIAL; MEMBRANE TRANSPORT/TRANSPORTERS; OCT; OCTN; PERMEABILITY; PULMONARY DELIVERY/ABSORPTION;

ANIMALS; BRONCHODILATOR AGENTS; GENE EXPRESSION; HEK293 CELLS; HUMANS; IPRATROPIUM; MICE; ORGANIC CATION TRANSPORT PROTEINS; RNA, MESSENGER; TRACHEA;

EID: 84881609137     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23603     Document Type: Article

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