Salbutamol: How does it enter smooth muscle cells?

International Journal of Immunopathology and Pharmacology

Volumn 25, Issue 2, 2012, Pages 541-546

  Chiappori, A ^a   Folli, C ^a   Riccio, A M ^a   Caci, E ^b   Descalzi, D ^a   De Ferrari, L ^a   Ingrassia, E ^c   Nicolini, G ^c   Canonica, Giorgio Walter ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

Bronchial smooth muscle cells; Corticosteroids; Organic cation transporter

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTERONE; OCTAMER TRANSCRIPTION FACTOR 4; SALBUTAMOL; ORGANIC CATION TRANSPORTER 3;

ARTICLE; BRONCHUS MUSCLE; DRUG UPTAKE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; CONTROLLED STUDY; DRUG TRANSPORT; PH; SMOOTH MUSCLE FIBER; TRANSPORT ASSAY;

EID: 84863645865     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201202500227     Document Type: Article

References (14)

1. Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007; 24(7):1227-51. (Pubitemid 46876495)
2. Hasannejad H, Takeda M, Narikawa S, et al. Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. Eur J Pharmacol 2004; 499(1-2):45-51. (Pubitemid 39201210)
3. Koepsell H. Polyspecific organic cation transporters: their functions and interactions with drugs. Trends in Pharmacological Sciences 2004; 25(7):375-81. (Pubitemid 38829491)
4. Volk C, Gorboulev V, Budiman T, Nagel G, Koepsell H. Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol Pharmacol 2003; 64(5):1037-47. (Pubitemid 37310736)
5. Arcucci A, Ruocco MR, Amatruda N, Riccio A, Tarantino G, Albano F, Mele V, Montagnani S. Analysis of extracellular superoxide dismutase in fibroblasts from patients with systemic sclerosis. J Biol Regul Homeost Agents 2011; 25(4):647-54.
6. Mancinelli R, Pietrangelo T, La Rovere R, Toniolo L, Fanò G, Reggiani C, Fulle S. Cellular and molecular responses of human skeletal muscle exposed to hypoxic environment. J Biol Regul Homeost Agents 2011; 25(4):635-45
7. van der Deen M, de Vries EG, Visserman H, Zandbergen W, Postma DS, Timens W. Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells. J Biochem Mol Toxicol 2007; 21(5):243-51. (Pubitemid 350006281)
8. Hayer-Zillgen M, Brüss M, Bönisch H. Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol 2002; 136(6):829-36. (Pubitemid 34836857)
9. Horvath G, Sutto Z, Torbati A, Conner GE, Salathe M, Wanner A. Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003; 285:L829-37. (Pubitemid 37158829)
10. Rosato E, Molinaro I, Pisarri S, Salsano F. Subcutaneous immunoglobulin therapy in a patient with myopathic dropped head syndrome and common variable immunodeficiency. J Biol Regul Homeost Agents 2011; 25(4):667-70.
11. Horvath G, Mendes ES, Schmid N, et al. The effect of corticosteroids on the disposal of long-acting beta2-agonists by airway smooth muscle cells. J Allergy Clin Immunol 2007; 120(5):1103-9. (Pubitemid 350029910)
12. Horvath G, Vasas S, Wanner A. Inhaled corticosteroids reduce asthma-associated airway hypoperfusion through genomic and nongenomic mechanisms. Pulm Pharmacol Ther 2007; 20:157-62. (Pubitemid 44780159)
13. Kummer W, Wiegand S, Akinci S, et al. Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res 2006; 7:65-77.
14. Russ H, Engel W, Schömig E. Isocyanines and pseudoisocyanines as a novel class of potent noradrenaline transport inhibitors: synthesis, detection, and biological activity. J Med Chem 1993; 36(26):4208-13. (Pubitemid 24037931)