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Volumn 5, Issue , 2015, Pages

Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OREXIN RECEPTOR; PEPTIDE FRAGMENT; QRFPR PROTEIN, HUMAN; RETINOIC ACID; TAU PROTEIN; ZINC SULFATE;

EID: 84938331166     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12584     Document Type: Article
Times cited : (56)

References (44)
  • 1
    • 84904891214 scopus 로고    scopus 로고
    • Ox1 and ox2 orexin/hypocretin receptor pharmacogenetics
    • Thompson, M. D. et al. OX1 and OX2 orexin/hypocretin receptor pharmacogenetics. Front Neurosci 8, 1-12 (2014).
    • (2014) Front Neurosci , vol.8 , pp. 1-12
    • Thompson, M.D.1
  • 2
    • 84883775015 scopus 로고    scopus 로고
    • Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders
    • Xu, T. R. et al. Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cell Signal 25, 2413-2423 (2013).
    • (2013) Cell Signal , vol.25 , pp. 2413-2423
    • Xu, T.R.1
  • 3
    • 0141920775 scopus 로고    scopus 로고
    • Orexin receptors and g-protein coupling: Evidence for another promiscuous" seven transmembrane domain receptor
    • Karteris, E. & Randeva, H. S. Orexin receptors and G-protein coupling: evidence for another "promiscuous" seven transmembrane domain receptor. J Pharmacol Sci. 93 126-128 (2003).
    • (2003) J Pharmacol Sci , vol.93 , pp. 126-128
    • Karteris, E.1    Randeva, H.S.2
  • 4
    • 84891278490 scopus 로고    scopus 로고
    • Orexin/hypocretin receptor signalling cascades
    • Kukkonen, J. P. & Leonard, C. S. Orexin/hypocretin receptor signalling cascades. Br J Pharmacol 171, 314-331 (2014).
    • (2014) Br J Pharmacol , vol.171 , pp. 314-331
    • Kukkonen, J.P.1    Leonard, C.S.2
  • 5
    • 84861881414 scopus 로고    scopus 로고
    • Hypocretin (orexin) loss in Alzheimer's disease
    • Fronczek, R. et al. Hypocretin (orexin) loss in Alzheimer's disease. Neurobiol Aging 33, 1642-1650 (2012).
    • (2012) Neurobiol Aging , vol.33 , pp. 1642-1650
    • Fronczek, R.1
  • 6
    • 84874899846 scopus 로고    scopus 로고
    • Association between hypocretin-1 and amyloid-? 42 cerebrospinal fluid levels in Alzheimer's disease and healthy controls
    • Slats, D. et al. Association between hypocretin-1 and amyloid-? 42 cerebrospinal fluid levels in Alzheimer's disease and healthy controls. Curr Alzheimer Res 9, 1119-1125 (2012).
    • (2012) Curr Alzheimer Res , vol.9 , pp. 1119-1125
    • Slats, D.1
  • 7
    • 84891912948 scopus 로고    scopus 로고
    • Hypocretin in cerebrospinal fluid is positively correlated with tau and ptau
    • Deuschle, M. et al. Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau. Neurosci Lett 561, 41-45 (2014).
    • (2014) Neurosci Lett , vol.561 , pp. 41-45
    • Deuschle, M.1
  • 8
    • 0041344654 scopus 로고    scopus 로고
    • Identification and characterization of a novel rf-Amide peptide ligand for orphan g-protein-coupled receptor sp9155
    • Jiang, Y. et al. Identification and characterization of a novel RF-Amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem 278, 27652-27657 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 27652-27657
    • Jiang, Y.1
  • 9
    • 84887008120 scopus 로고    scopus 로고
    • Qrfp induces aldosterone production via pkc and t-type calcium channel-mediated pathways in human adrenocortical cells: Evidence for a novel role of gpr103
    • Ramanjaneya, M. et al. QRFP induces aldosterone production via PKC and T-type calcium channel-mediated pathways in human adrenocortical cells: evidence for a novel role of GPR103. Am J Physiol 305, 1049-1058 (2013).
    • (2013) Am J Physiol , vol.305 , pp. 1049-1058
    • Ramanjaneya, M.1
  • 11
    • 0035051332 scopus 로고    scopus 로고
    • Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration
    • Harper, D. G. et al. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry 58, 353-360 (2001).
    • (2001) Arch Gen Psychiatry , vol.58 , pp. 353-360
    • Harper, D.G.1
  • 12
    • 36749094529 scopus 로고    scopus 로고
    • The effect of antagonization of orexin 1 receptors in ca1 and dentate gyrus regions on memory processing in passive avoidance task
    • Akbari, E., Motamedi, F., Naghdi, N. & Noorbakhshnia, M. The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task. Behav Brain Res 187, 172-177 (2008).
    • (2008) Behav Brain Res , vol.187 , pp. 172-177
    • Akbari, E.1    Motamedi, F.2    Naghdi, N.3    Noorbakhshnia, M.4
  • 13
    • 33750027158 scopus 로고    scopus 로고
    • Functional inactivation of orexin 1 receptors in ca1 region impairs acquisition, consolidation and retrieval in morris water maze task
    • Akbari, E., Naghdi, N. & Motamedi, F. Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task. Behav Brain Res 173, 47-52 (2006).
    • (2006) Behav Brain Res , vol.173 , pp. 47-52
    • Akbari, E.1    Naghdi, N.2    Motamedi, F.3
  • 15
    • 46749151737 scopus 로고    scopus 로고
    • Tau isoform expression and regulation in human cortical neurons
    • Deshpande, A., Win, K. M. & Busciglio, J. Tau isoform expression and regulation in human cortical neurons. FASEB J 22, 2357-67 (2008).
    • (2008) FASEB J , vol.22 , pp. 2357-2367
    • Deshpande, A.1    Win, K.M.2    Busciglio, J.3
  • 16
    • 84857642949 scopus 로고    scopus 로고
    • The toxic a Oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova, I. Karran, E. & De Strooper, B. The toxic A oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 15, 349-357 (2012).
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 17
    • 0037380001 scopus 로고    scopus 로고
    • A welcoming environment for amyloid plaques
    • Carlson, G. A. A welcoming environment for amyloid plaques. Nat Neurosci 6, 328-330 (2003).
    • (2003) Nat Neurosci , vol.6 , pp. 328-330
    • Carlson, G.A.1
  • 18
    • 80051725947 scopus 로고    scopus 로고
    • Erk/mapk is essential for endogenous neuroprotection in scn2.2 cells
    • Karmarkar, S. W. Bottum, K. M., Krager, S. L. & Tischkau, S. A. ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells. PLoS One 6, e23493 (2011).
    • (2011) PLoS One , vol.6 , pp. e23493
    • Karmarkar, S.W.1    Bottum, K.M.2    Krager, S.L.3    Tischkau, S.A.4
  • 19
    • 78650525484 scopus 로고    scopus 로고
    • Erk activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of huntington's disease
    • Maher, P. et al. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum Mol Genet 20, 261-270 (2011).
    • (2011) Hum Mol Genet , vol.20 , pp. 261-270
    • Maher, P.1
  • 20
    • 84895075249 scopus 로고    scopus 로고
    • Orexins protect neuronal cell cultures against hypoxic stress: An involvement of akt signalling
    • Sokoowska, P. et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of akt signalling. J Mol Neurosci 52, 48-55 (2014).
    • (2014) J Mol Neurosci , vol.52 , pp. 48-55
    • Sokoowska, P.1
  • 21
    • 84938407477 scopus 로고    scopus 로고
    • Nf-kappab: Emerging roles in hippocampal development and function
    • Crampton, S. J. & O'Keeffe, G. W. NF-kappaB: emerging roles in hippocampal development and function. Int J Biochem Cell Biol 52, 48-55 (2014).
    • (2014) Int J Biochem Cell Biol , vol.52 , pp. 48-55
    • Crampton, S.J.1    O'Keeffe, G.W.2
  • 22
    • 84908053927 scopus 로고    scopus 로고
    • Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of erk(1/2) and cell proliferation via g? Q-mediated mechanism
    • Bai, B., Cai, X., Jiang, Y., Karteris, E. & Chen, J. Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via G? q-mediated mechanism. J Cell Mol Med 18, 2071-2081 (2014).
    • (2014) J Cell Mol Med , vol.18 , pp. 2071-2081
    • Bai, B.1    Cai, X.2    Jiang, Y.3    Karteris, E.4    Chen, J.5
  • 23
    • 84899768884 scopus 로고    scopus 로고
    • Involvement of erk1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced sh-sy5y cell injury
    • Zhang, Q. et al. Involvement of ERK1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced SH-SY5Y cell injury. Neuroscience 270, 183-191 (2014).
    • (2014) Neuroscience , vol.270 , pp. 183-191
    • Zhang, Q.1
  • 25
    • 84858203893 scopus 로고    scopus 로고
    • Fluorescence/bioluminescence resonance energy transfer techniques to study g-proteincoupled receptor activation and signaling
    • Lohse, M. J., Nuber, S. & Hoffmann, C. Fluorescence/bioluminescence resonance energy transfer techniques to study G-proteincoupled receptor activation and signaling. Pharmacol Rev 64, 299-336 (2012).
    • (2012) Pharmacol Rev , vol.64 , pp. 299-336
    • Lohse, M.J.1    Nuber, S.2    Hoffmann, C.3
  • 26
    • 33645961571 scopus 로고    scopus 로고
    • Quantification of oxidized rnas in Alzheimer's disease
    • Shan, X. & Lin, C. L. Quantification of oxidized RNAs in Alzheimer's disease. Neurobiol Aging 27, 657-662 (2006).
    • (2006) Neurobiol Aging , vol.27 , pp. 657-662
    • Shan, X.1    Lin, C.L.2
  • 27
    • 0037133283 scopus 로고    scopus 로고
    • Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or r-Alpha-lipoic acid
    • Liu, J. et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-Alpha-lipoic acid. PNAS 99, 2356-2361 (2002)
    • (2002) PNAS , vol.99 , pp. 2356-2361
    • Liu, J.1
  • 28
    • 84881090595 scopus 로고    scopus 로고
    • Calorie restriction and resveratrol supplementation prevent age-related DNA and RNA oxidative damage in a non-human primate
    • Marchal, J. et al. Calorie restriction and resveratrol supplementation prevent age-related DNA and RNA oxidative damage in a non-human primate. Exp Gerontol 48, 992-1000 (2013).
    • (2013) Exp Gerontol , vol.48 , pp. 992-1000
    • Marchal, J.1
  • 29
    • 1642430685 scopus 로고    scopus 로고
    • The effect of age on prepro-orexin gene expression and contents of orexin a and b in the rat brain
    • Porkka-Heiskanen, T., Alanko, L., Kalinchuk, A., Heiskanen, S. & Stenberg, D. The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain. Neurobiol Aging 25, 231-238 (2004).
    • (2004) Neurobiol Aging , vol.25 , pp. 231-238
    • Porkka-Heiskanen, T.1    Alanko, L.2    Kalinchuk, A.3    Heiskanen, S.4    Stenberg, D.5
  • 30
    • 0037044586 scopus 로고    scopus 로고
    • Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain
    • Terao, A., Apte-Deshpande, A., Morairty, S., Freund, Y. R. & Kilduff, T. S. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 332, 190-194 (2002).
    • (2002) Neurosci Lett , vol.332 , pp. 190-194
    • Terao, A.1    Apte-Deshpande, A.2    Morairty, S.3    Freund, Y.R.4    Kilduff, T.S.5
  • 31
    • 72449161215 scopus 로고    scopus 로고
    • Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
    • Kang, J. E. et al. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle". Science 326, 1005-1007 (2009).
    • (2009) Science , vol.326 , pp. 1005-1007
    • Kang, J.E.1
  • 32
    • 84856668816 scopus 로고    scopus 로고
    • Vip enhances phagocytosis of fibrillar beta-Amyloid by microglia and attenuates amyloid deposition in the brain of app/ps1 mice
    • Song, M., Xiong, J. X., Wang, Y. Y., Tang, J., Zhang, B. & Bai, Y. VIP enhances phagocytosis of fibrillar beta-Amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice. PloS One 7, e29790 (2012).
    • (2012) PloS One , vol.7 , pp. e29790
    • Song, M.1    Xiong, J.X.2    Wang, Y.Y.3    Tang, J.4    Zhang, B.5    Bai, Y.6
  • 33
    • 21844431659 scopus 로고    scopus 로고
    • Etiology of sporadic Alzheimer's disease: Somatostatin, neprilysin, and amyloid beta peptide
    • Hama, E. & Saido, T. C. Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide. Med Hypotheses 65, 498-500 (2005).
    • (2005) Med Hypotheses , vol.65 , pp. 498-500
    • Hama, E.1    Saido, T.C.2
  • 34
    • 83855165674 scopus 로고    scopus 로고
    • Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models
    • Lee, S. T. et al. Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models. J Neurochem 120, 115-124 (2012).
    • (2012) J Neurochem , vol.120 , pp. 115-124
    • Lee, S.T.1
  • 35
    • 23844457609 scopus 로고    scopus 로고
    • Levels of mtor and its downstream targets 4e-bp1, eef2, and eef2 kinase in relationships with tau in Alzheimer's disease brain
    • Li, X., Alafuzoff, I., Soininen, H., Winblad, B. & Pei, J. J. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J 272, 4211-4220 (2005).
    • (2005) FEBS J , vol.272 , pp. 4211-4220
    • Li, X.1    Alafuzoff, I.2    Soininen, H.3    Winblad, B.4    Pei, J.J.5
  • 36
    • 0034988228 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease
    • Pedersen, W. A. et al. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiol Disease 8, 492-503 (2001).
    • (2001) Neurobiol Disease , vol.8 , pp. 492-503
    • Pedersen, W.A.1
  • 37
    • 84890576583 scopus 로고    scopus 로고
    • Pericyte loss influences Alzheimer-like neurodegeneration in mice
    • Sagare, A. P. et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun 4, 2932 (2013).
    • (2013) Nat Commun , vol.4 , pp. 2932
    • Sagare, A.P.1
  • 38
    • 19444364013 scopus 로고    scopus 로고
    • Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex
    • Karteris, E. et al. Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. Am J Physiol Endocrinol Metab 288, 1089-100 (2005).
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. 1089-1100
    • Karteris, E.1
  • 42
    • 65249180758 scopus 로고    scopus 로고
    • Dominant negative at2 receptor oligomers induce g-protein arrest and symptoms of neurodegeneration
    • AbdAlla, S. et al. Dominant negative AT2 receptor oligomers induce G-protein arrest and symptoms of neurodegeneration. J Biol Chem 284, 6566-74 (2009).
    • (2009) J Biol Chem , vol.284 , pp. 6566-6574
    • AbdAlla, S.1
  • 43
    • 84896082268 scopus 로고    scopus 로고
    • Human orexin/hypocretin receptors form constitutive homo-And heteromeric complexes with each other and with human cb1 cannabinoid receptors
    • Jäntti, M. H., Mandrika, I. & Kukkonen, J. P. Human orexin/hypocretin receptors form constitutive homo-And heteromeric complexes with each other and with human CB1 cannabinoid receptors. Biochem Biophys Res Commun 445, 486-490 (2014).
    • (2014) Biochem Biophys Res Commun , vol.445 , pp. 486-490
    • Jäntti, M.H.1    Mandrika, I.2    Kukkonen, J.P.3
  • 44
    • 34447298908 scopus 로고    scopus 로고
    • Distribution of 26rfa binding sites and gpr103 mRNA in the central nervous system of the rat
    • Bruzzone, F. et al. Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J Comp Neurol 503, 573-591 (2007).
    • (2007) J Comp Neurol , vol.503 , pp. 573-591
    • Bruzzone, F.1


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