-
1
-
-
0033914982
-
Mild cognitive impairment: Identifying and treating the earliest stages of Alzheimer's disease
-
J. Golomb, A. Kluger, and S.H. Ferris Mild cognitive impairment: identifying and treating the earliest stages of Alzheimer's disease Neurosci News 3 4 2000 46 53
-
(2000)
Neurosci News
, vol.3
, Issue.4
, pp. 46-53
-
-
Golomb, J.1
Kluger, A.2
Ferris, S.H.3
-
2
-
-
16044366039
-
Increased amyloid-β 42 (43) in brains of mice expressing mutant presenilin 1
-
K. Duff, C. Eckman, and C. Zehr Increased amyloid-β 42 (43) in brains of mice expressing mutant presenilin 1 Nature 383 1996 710 713
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
3
-
-
16044365171
-
The E280A Presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: Increased Aβ42 deposition and severe cerebellar pathology
-
C.A. Lemere, F. Lopera, and K.S. Kosik The E280A Presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: increased Aβ42 deposition and severe cerebellar pathology Nat Med 2 1996 1146 1150
-
(1996)
Nat Med
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
-
4
-
-
0033621739
-
1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
-
1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition Nat Med 6 2000 143 150
-
(2000)
Nat Med
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
-
5
-
-
0035947207
-
Metabolic regulation of brain Aβ by neprilysin
-
N. Iwata, S. Tsubuki, and Y. Takaki Metabolic regulation of brain Aβ by neprilysin Science 292 2001 1550 1552
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
-
6
-
-
0037010286
-
Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
-
N. Iwata, Y. Takaki, and S. Fukami Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging J Neurosci Res 70 2002 493 500
-
(2002)
J Neurosci Res
, vol.70
, pp. 493-500
-
-
Iwata, N.1
Takaki, Y.2
Fukami, S.3
-
7
-
-
0035846826
-
Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of β-amyloid peptide
-
K. Yasojima, H. Akiyama, and E.G. McGeer Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide Neurosci Lett 297 2001 97 100
-
(2001)
Neurosci Lett
, vol.297
, pp. 97-100
-
-
Yasojima, K.1
Akiyama, H.2
McGeer, E.G.3
-
8
-
-
0038204547
-
Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation
-
S. Tsubuki, Y. Takaki, and T.C. Saido Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation Lancet 361 2003 1957 1958
-
(2003)
Lancet
, vol.361
, pp. 1957-1958
-
-
Tsubuki, S.1
Takaki, Y.2
Saido, T.C.3
-
9
-
-
17644425569
-
42 through modulation of proteolytic degradation
-
42 through modulation of proteolytic degradation Nat Med 4 2005 434 439
-
(2005)
Nat Med
, vol.4
, pp. 434-439
-
-
Saito, T.1
Iwata, N.2
Tsubuki, S.3
-
10
-
-
0031041781
-
Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: Decreased levels of mRNA during aging
-
M. Hayashi, A. Yamashita, and K. Shimizu Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNA during aging Brain Res 749 1997 283 289
-
(1997)
Brain Res
, vol.749
, pp. 283-289
-
-
Hayashi, M.1
Yamashita, A.2
Shimizu, K.3
-
11
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
T. Lu, Y. Pan, and S.Y. Kao Gene regulation and DNA damage in the ageing human brain Nature 429 2004 883 891
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.Y.3
-
12
-
-
0019256571
-
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer's disease and Alzheimer senile dementia
-
P. Davies, R. Katzman, and R.D. Terry Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer's disease and Alzheimer senile dementia Nature 288 1980 279 280
-
(1980)
Nature
, vol.288
, pp. 279-280
-
-
Davies, P.1
Katzman, R.2
Terry, R.D.3
-
13
-
-
0141514419
-
Oxidized neprilysin in aging and Alzheimer's disease brains
-
D.-S. Wang, N. Iwata, E. Hama, T.C. Saido, and D.W. Dickson Oxidized neprilysin in aging and Alzheimer's disease brains Biochem Biophys Res Commun 310 2003 236 241
-
(2003)
Biochem Biophys Res Commun
, vol.310
, pp. 236-241
-
-
Wang, D.-S.1
Iwata, N.2
Hama, E.3
Saido, T.C.4
Dickson, D.W.5
-
14
-
-
0032902647
-
The amyloid precursor protein of Alzheimer's disease and the Aβ peptide
-
E. Storey, and R. Capprai The amyloid precursor protein of Alzheimer's disease and the Aβ peptide Neuropathol Appl Neurobiol 25 1999 81 97
-
(1999)
Neuropathol Appl Neurobiol
, vol.25
, pp. 81-97
-
-
Storey, E.1
Capprai, R.2
-
15
-
-
0035900189
-
Relationship between β amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
-
K. Yasojima, E.G. McGeer, and P.L. McGeer Relationship between β amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain Brain Res 919 2001 115 121
-
(2001)
Brain Res
, vol.919
, pp. 115-121
-
-
Yasojima, K.1
McGeer, E.G.2
McGeer, P.L.3
-
16
-
-
12144286502
-
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
-
R. Li, K. Lindholm, and L.B. Yang Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients Proc Natl Acad Sci USA 101 2004 3632 3637
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3632-3637
-
-
Li, R.1
Lindholm, K.2
Yang, L.B.3
-
17
-
-
0031781795
-
Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease
-
H. Funato, M. Yoshimura, and K. Kusui Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease Am J Pathol 152 1998 1633 1640
-
(1998)
Am J Pathol
, vol.152
, pp. 1633-1640
-
-
Funato, H.1
Yoshimura, M.2
Kusui, K.3
|