Orexins Protect Neuronal Cell Cultures Against Hypoxic Stress: An Involvement of Akt Signaling

Journal of Molecular Neuroscience

Volumn 52, Issue 1, 2014, Pages 48-55

  Sokołowska, Paulina ^a   Urbańska, Anna ^a   Biegańska, Kaja ^a,b   Wagner, Waldemar ^a   Ciszewski, Wojciech ^a   Namiecińska, Magdalena ^a   Zawilska, Jolanta B ^a,b  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Akt kinase; Chemical hypoxia; Neuroprotection; Orexin

Indexed keywords

COBALT CHLORIDE; OREXIN A; OREXIN B; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN CELL CULTURE; CELL HYPOXIA; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION;

RATTUS;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; COBALT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; NEUROPEPTIDES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84895075249     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0165-7     Document Type: Article

References (57)

1. Alvarez CE, Sutcliffe JG (2002) Hypocretin is an early member of the incretin gene family. Neurosci Lett 324:169-172
2. 2 receptors by orexin peptides. J Pharmacol Exp Ther 305:507-514
3. 1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress- activated protein kinase. J Biol Chem 281:834-842
4. Aston-Jones G, Smith RJ, Sartor GC, Moorman DE, Massi L, Tahsili-Fahadan P, Richardson KA (2010) Lateral hypothalamic orexin/hypocretin neurons: a role in reward seeking and addiction. Brain Res 1314:74-90
5. Berthoud HR, Patterson LM, Sutton GM, Morrison C, Zheng H (2005) Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 123:147-156
6. Brewer GJ (1995) Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 42:674-483
7. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868
8. Brunet A, Datta SR, Greenberg ME (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11:297-305
9. Butterick TA, Nixon JP, Billington CJ, Kotz CM (2012) Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model. Neurosci Lett 524:30-34
10. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 95:11715-11720
11. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451
12. Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY (2003) Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell 113:457-468
13. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic machinery. Cell 91:231-241
14. de Lecea L, Kilduff TS, Peyron C, Gao XB, Foye PE, Danielson PE, Fukuhara C, Battenberg ELF, Gautvik VT, Bartlett VS, Frankel WN, van den Pol N, Bloom E, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95:322-327
15. Diez H, Garrido JJ, Wandosell F (2012) Specific roles of Akt isoforms in apoptosis and axon growth regulation in neurons. PLoS One 7:e32715
16. Du K, Montminy M (1998) CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273:32377-32379
17. Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA (2004) Convergent evidence for impaired AKT-GSK3β signaling in schizophrenia. Nat Genet 36:131-137
18. Göncz E, Strowski MZ, Grotzinger C, Nowak KW, Kaczmarek P, Sassek M, Mergler S, El-Zayat BE, Theodoropoulou M, Stalla GK, Wiedenmann B, Plöckinger U (2007) Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway. Endocrinology 149:1618-1626
19. 1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. J Biol Chem 280:6570-6579
20. Ibarretxe G, Sanchez-Gomez MV, Campos-Esparza MR, Alberdi E, Matute C (2006) Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols. Glia 53:201-211
21. 2+ influx. Br J Pharmacol 150:97-104
22. Kitamura E, Hamada J, Kanazawa N, Yonekura J, Masuda R, Sakai F, Mochizuki H (2010) The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia. Neurosci Res 68:154-157
23. Kukkonen JP (2012) Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol 304:C2-C32
24. Kukkonen JP, Holmqvist T, Ammoun S, Åkerman KEO (2002) Functions of the orexinergic/hypocretinergic system. Am J Physiol Cell Physiol 283:1567-1591
25. 2TMRos). Biosci Rep 21:341-352
26. Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron 50:377-388
27. Lampe K, Bjugstad KB, Mahoney MJ (2010) Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation. Tissue Eng A 16:1857-1866
28. Liao FF, Xu H (2009) Insulin signaling in sporadic Alzheimer's disease. Sci Signal 2:pe36
29. 2+ influx pathway necessary for coupling to phospholipase C. J Biol Chem 275:30806-30812
30. 2+ signalling by the orexin receptor type 1. Biochem Pharmacol 71:827-836
31. Mazzocchi G, Malendowicz LK, Aragona F, Rebuffat P, Gottardo L, Nussdorfer GG (2001) Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B. J Clin Endocrinol Metab 86:4818-4821
32. Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M (2004) Orexin peptides prevent cataplexy and improve wakefulness in a orexin-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A 101:4649-4654
33. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K (1999) Distribution of orexin neurons in the adult rat brain. Brain Res 827:243-260
34. Nowak JZ, Jozwiak-Bebenista M, Bednarek K (2007) Effects of PACAP and VIP on cyclic AMP formation in rat neuronal and astrocyte cultures under normoxic and hypoxic condition. Peptides 28:1706-1712
35. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85
36. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015
37. Ramanjaneya M, Conner AC, Chen J, Kumar P, Brown JEP, Jöhren O, Lehnert H, Stanfield PR, Randeva HS (2009) Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signaling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B. J Endocrinol 202:249-261
38. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001) Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab 86:4808-4813
39. 1 receptor suppress cell growth by inducing apoptosis. J Biol Chem 279:45875-45886
40. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585
41. Skrzypski M, Le TT, Kaczmarek P, Pruszynska-Oszmalek E, Pietrzak P, Szczepankiewicz D, Kolodziejski PA, Sassek M, Arafat A, Wiedenmann B, Nowak KW, Strowski MZ (2011) Orexin A stimulates glucose uptake, lipid accumulation and adiponect in primary rat adipocytes. Diabetologia 54:1841-1852
42. Sokołowska P, Urbańska A, Namiecińska M, Biegańska K, Zawilska JB (2012) Orexins promote survival of rat cortical neurons. Neurosci Lett 506:303-306
43. Spinazzi R, Andreis PG, Rossi GP, Nussdorfer GG (2006) Orexins in the regulation of the hypothalamic-pituitary-adrenal axis. Pharmacol Rev 58:46-57
44. Stenger C, Naves T, Verdier M, Ratinaud MH (2011) The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status. Int J Oncol 39:601-609
45. Tang J, Chen J, Ramanjaneya M, Punn A, Conner AC, Randeva HS (2008) The signalling profile of recombinant human orexin-2 receptor. Cell Signal 20:1651-1661
46. Thompson JL, Borgland SL (2011) A role for hypocretin/orexin in motivation. Behav Brain Res 217:446-453
47. 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. J Mol Neurosci 46:10-17
48. Vengellur A, LaPres JJ (2004) The role of hypoxia inducible factor 1α in cobalt chloride induced cell death in mouse embryonic fibroblasts. Toxicol Sci 82:638-646
49. Voisin T, Rouet-Benzineb P, Reuter N, Laburthe M (2003) Orexins and their receptors: structural aspects and role in peripheral tissue. Cell Mol Life Sci 60:72-87
50. Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR (2009) Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments. Mol Cell Neurosci 40:121-127
51. Woldan-Tambor A, Biegańska K, Wiktorowska-Owczarek A, Zawilska JB (2011) Activation of orexin/hypocretin type 1-like receptors stimulates cAMP synthesis in primary cultures of rat astrocytes. Pharmacol Rep 63:717-723
52. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M (2001) Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276:5256-5264
53. Yuan LB, Dong HL, Zhang HP, Zhoa RN, Gong G, Chen XM, Zhang LN, Xiong L (2011) Neuroprotective effect of orexin-A is mediated by an increase of hypoxia-inducible factor-1 activity in rat. Anesthesiology 114:340-354
54. Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F (2008) Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum Mol Genet 17:3837-3846
55. Zawilska JB, Urbańska A, Sokołowska P (2013) Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons. Pharmacol Rep 65:513-516
56. Zhang W, Zhang N, Sakurai T, Kuwaki T (2009) Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdale and bed nucleus of the stria terminalis. Brain Res 1262:25-37
57. Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K (2003) Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci 92:259-266