-
1
-
-
58149463424
-
MTOR-dependent signalling in Alzheimer's disease
-
Pei JJ and Hugon J: mTOR-dependent signalling in Alzheimer's disease. J Cell Mol Med 12: 2525-2532, 2008.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 2525-2532
-
-
Pei, J.J.1
Hugon, J.2
-
3
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, et al: A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369: 756-758, 1994.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
-
4
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC and Thomas G: Mammalian TOR: A homeostatic ATP sensor. Science 294: 1102-1105, 2001.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
5
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R and Hall MN: TOR signaling in growth and metabolism. Cell 124: 471-484, 2006.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
6
-
-
75749114797
-
MTOR signaling: At the crossroads of plasticity, memory and disease
-
Hoeffer CA and Klann E: mTOR signaling: At the crossroads of plasticity, memory and disease. Trends Neurosci 2: 67-75, 2010.
-
(2010)
Trends Neurosci
, vol.2
, pp. 67-75
-
-
Hoeffer, C.A.1
Klann, E.2
-
7
-
-
33749077101
-
Dendritic protein synthesis, synaptic plasticity, and memory
-
Sutton MA and Schuman EM: Dendritic protein synthesis, synaptic plasticity, and memory. Cell 127: 49-58, 2006.
-
(2006)
Cell
, vol.127
, pp. 49-58
-
-
Sutton, M.A.1
Schuman, E.M.2
-
8
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395, 2009.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
9
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al: Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326: 140-144, 2009.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
-
10
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, et al: Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28: 6926-6937, 2008.
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
-
11
-
-
21344459656
-
MTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease
-
Lafay-Chebassier C, Paccalin M, Page G, Barc-Pain S, Perault-Pochat MC, Gil R, et al: mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J Neurochem 94: 215-225, 2005.
-
(2005)
J Neurochem
, vol.94
, pp. 215-225
-
-
Lafay-Chebassier, C.1
Paccalin, M.2
Page, G.3
Barc-Pain, S.4
Perault-Pochat, M.C.5
Gil, R.6
-
12
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al: Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5: e9979, 2010.
-
(2010)
PLoS One
, vol.5
, pp. e9979
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
-
13
-
-
77958465822
-
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
-
Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, et al: Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One 5: e12845, 2010.
-
(2010)
PLoS One
, vol.5
, pp. e12845
-
-
Ma, T.1
Hoeffer, C.A.2
Capetillo-Zarate, E.3
Yu, F.4
Wong, H.5
Lin, M.T.6
-
14
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886, 2009.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
15
-
-
77449090901
-
Dynamic balancing: DEPTOR tips the scales
-
Proud CG: Dynamic balancing: DEPTOR tips the scales. J Mol Cell Biol 1: 61-63, 2009.
-
(2009)
J Mol Cell Biol
, vol.1
, pp. 61-63
-
-
Proud, C.G.1
-
16
-
-
77958524854
-
Differential expression of mTOR signalling components in drug resistance in ovarian cancer
-
Foster H, Coley HM, Goumenou A, Pados G, Harvey A and Karteris E: Differential expression of mTOR signalling components in drug resistance in ovarian cancer. Anticancer Res 30: 3529-3534, 2010.
-
(2010)
Anticancer Res
, vol.30
, pp. 3529-3534
-
-
Foster, H.1
Coley, H.M.2
Goumenou, A.3
Pados, G.4
Harvey, A.5
Karteris, E.6
-
17
-
-
78449241484
-
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
-
Liu M, Wilk SA, Wang A, Zhou L, Wang RH, Ogawa W, et al: Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem 285: 36387-36394, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 36387-36394
-
-
Liu, M.1
Wilk, S.A.2
Wang, A.3
Zhou, L.4
Wang, R.H.5
Ogawa, W.6
-
18
-
-
84858778505
-
Resveratrol: A neuroprotective polyphenol in the Mediterranean diet
-
Lopez-Miranda V, Soto-Montenegro ML, Vera G, Herradon E, Desco M and Abalo R: Resveratrol: A neuroprotective polyphenol in the Mediterranean diet. Rev Neurol 54: 349-356, 2012.
-
(2012)
Rev Neurol
, vol.54
, pp. 349-356
-
-
Lopez-Miranda, V.1
Soto-Montenegro, M.L.2
Vera, G.3
Herradon, E.4
Desco, M.5
Abalo, R.6
-
19
-
-
84862786365
-
Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2
-
Li Z, Pang L, Fang F, Zhang G, Zhang J, Xie M, et al: Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2. Brain Res 1450: 116-124, 2012.
-
(2012)
Brain Res
, vol.1450
, pp. 116-124
-
-
Li, Z.1
Pang, L.2
Fang, F.3
Zhang, G.4
Zhang, J.5
Xie, M.6
-
20
-
-
84855283935
-
Resveratrol protects rats from Abeta-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation
-
Huang TC, Lu KT, Wo YY, Wu YJ and Yang YL: Resveratrol protects rats from Abeta-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation. PLoS One 6: e29102, 2011.
-
(2011)
PLoS One
, vol.6
, pp. e29102
-
-
Huang, T.C.1
Lu, K.T.2
Wo, Y.Y.3
Wu, Y.J.4
Yang, Y.L.5
-
21
-
-
84856387751
-
Placental DEPTOR as a stress sensor during pregnancy
-
Mparmpakas D, Zachariades E, Goumenou A, Gidron Y and Karteris E: Placental DEPTOR as a stress sensor during pregnancy. Clin Sci (Lond) 122: 349-359, 2012.
-
(2012)
Clin Sci (Lond)
, vol.122
, pp. 349-359
-
-
Mparmpakas, D.1
Zachariades, E.2
Goumenou, A.3
Gidron, Y.4
Karteris, E.5
-
22
-
-
6344269168
-
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
-
Li X, An WL, Alafuzoff I, Soininen H, Winblad B and Pei JJ: Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain. Neuroreport 15: 2237-2240, 2004.
-
(2004)
Neuroreport
, vol.15
, pp. 2237-2240
-
-
Li, X.1
An, W.L.2
Alafuzoff, I.3
Soininen, H.4
Winblad, B.5
Pei, J.J.6
-
23
-
-
47549088485
-
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: A clinicopathologic study
-
Steinerman JR, Irizarry M, Scarmeas N, Raju S, Brandt J, Albert M, et al: Distinct pools of beta-amyloid in Alzheimer disease-affected brain: A clinicopathologic study. Arch Neurol 65: 906-912, 2008.
-
(2008)
Arch Neurol
, vol.65
, pp. 906-912
-
-
Steinerman, J.R.1
Irizarry, M.2
Scarmeas, N.3
Raju, S.4
Brandt, J.5
Albert, M.6
-
24
-
-
0029671451
-
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
-
Kuo YM, Emmerling MR, Vigo-Pelfrey C, Kasunic TC, Kirkpatrick JB, Murdoch GH, et al: Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem 271: 4077-4081, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
Kasunic, T.C.4
Kirkpatrick, J.B.5
Murdoch, G.H.6
-
25
-
-
0032837741
-
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
-
Wang J, Dickson DW, Trojanowski JQ and Lee VM: The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 158: 328-337, 1999.
-
(1999)
Exp Neurol
, vol.158
, pp. 328-337
-
-
Wang, J.1
Dickson, D.W.2
Trojanowski, J.Q.3
Lee, V.M.4
-
26
-
-
84883648855
-
Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration
-
Dwane S, Durack E and Kiely PA: Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration. BMC Res Notes 6: 366, 2013.
-
(2013)
BMC Res Notes
, vol.6
, pp. 366
-
-
Dwane, S.1
Durack, E.2
Kiely, P.A.3
-
27
-
-
37549010213
-
The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism
-
Petratos S, Li QX, George AJ, Hou X, Kerr ML, Unabia SE, et al: The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain 131: 90-108, 2008.
-
(2008)
Brain
, vol.131
, pp. 90-108
-
-
Petratos, S.1
Li, Q.X.2
George, A.J.3
Hou, X.4
Kerr, M.L.5
Unabia, S.E.6
-
28
-
-
33646341231
-
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
-
Bachmann RA, Kim JH, Wu AL, Park IH and Chen J: A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1. J Biol Chem 281: 7357-7363, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 7357-7363
-
-
Bachmann, R.A.1
Kim, J.H.2
Wu, A.L.3
Park, I.H.4
Chen, J.5
-
29
-
-
84903637959
-
Sleep deficits in mild cognitive impairment are associated with increased plasma amyloid-beta levels and cortical thinning
-
Sanchez-Espinosa MP, Atienza M and Cantero JL: Sleep deficits in mild cognitive impairment are associated with increased plasma amyloid-beta levels and cortical thinning. Neuroimage 98: 395-404, 2014.
-
(2014)
Neuroimage
, vol.98
, pp. 395-404
-
-
Sanchez-Espinosa, M.P.1
Atienza, M.2
Cantero, J.L.3
-
30
-
-
80055060529
-
Mapping the structural brain changes in Alzheimer's disease: The independent contribution of two imaging modalities
-
Canu E, McLaren DG, Fitzgerald ME, Bendlin BB, Zoccatelli G, Alessandrini F, et al: Mapping the structural brain changes in Alzheimer's disease: The independent contribution of two imaging modalities. J Alzheimers Dis 26 (Suppl 3): S263-S274, 2011.
-
(2011)
J Alzheimers Dis
, vol.26
, pp. S263-S274
-
-
Canu, E.1
McLaren, D.G.2
Fitzgerald, M.E.3
Bendlin, B.B.4
Zoccatelli, G.5
Alessandrini, F.6
-
31
-
-
84896730844
-
Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease
-
Banno K, Nakaaki S, Sato J, Torii K, Narumoto J, Miyata J, et al: Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease. Neuropsychiatr Dis Treat 10: 339-348, 2014.
-
(2014)
Neuropsychiatr Dis Treat
, vol.10
, pp. 339-348
-
-
Banno, K.1
Nakaaki, S.2
Sato, J.3
Torii, K.4
Narumoto, J.5
Miyata, J.6
-
32
-
-
77249086612
-
Neural correlates of psychotic symptoms in dementia with Lewy bodies
-
Nagahama Y, Okina T, Suzuki N and Matsuda M: Neural correlates of psychotic symptoms in dementia with Lewy bodies. Brain 133: 557-567, 2010.
-
(2010)
Brain
, vol.133
, pp. 557-567
-
-
Nagahama, Y.1
Okina, T.2
Suzuki, N.3
Matsuda, M.4
-
34
-
-
79952897860
-
Unraveling the biological mechanisms in Alzheimer's disease-lessons from genomics
-
Borovecki F, Klepac N, Muck-Seler D, Hajnsek S, Mubrin Z and Pivac N: Unraveling the biological mechanisms in Alzheimer's disease-lessons from genomics. Prog Neuropsychopharmacol Biol Psychiatry 35: 340-37, 2010.
-
(2010)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.35
, pp. 340-437
-
-
Borovecki, F.1
Klepac, N.2
Muck-Seler, D.3
Hajnsek, S.4
Mubrin, Z.5
Pivac, N.6
-
35
-
-
79953208952
-
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism
-
Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magri A, et al: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem 286: 8924-8932, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 8924-8932
-
-
Caccamo, A.1
Maldonado, M.A.2
Majumder, S.3
Medina, D.X.4
Holbein, W.5
Magri, A.6
-
36
-
-
84862798401
-
Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for Alzheimer's disease?
-
Cai Z, Zhao B, Li K, Zhang L, Li C, Quazi SH, et al: Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for Alzheimer's disease? J Neurosci Res 90: 1105-1118, 2012.
-
(2012)
J Neurosci Res
, vol.90
, pp. 1105-1118
-
-
Cai, Z.1
Zhao, B.2
Li, K.3
Zhang, L.4
Li, C.5
Quazi, S.H.6
|