Ondansetron attenuates co-morbid depression and anxiety associated with obesity by inhibiting the biochemical alterations and improving serotonergic neurotransmission

Pharmacology Biochemistry and Behavior

Volumn 136, Issue , 2015, Pages 107-116

  Kurhe, Yeshwant ^a   Mahesh, Radhakrishnan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Anxiety leptin; Depression; HPA axis; Insulin; Oxidative stress; Serotonin

Indexed keywords

CORTICOSTERONE; ESCITALOPRAM; FAT; GLUCOSE; GLUTATHIONE; INSULIN; LEPTIN; MALONALDEHYDE; ONDANSETRON; SEROTONIN; SUCROSE; WATER; CITALOPRAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; ATTENUATION; BLOOD CHEMISTRY; BRAIN; COMORBIDITY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DISEASE SEVERITY; DRUG EFFICACY; FORCED SWIM TEST; HOLE BOARD TEST; HYPERACTIVITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILITY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIGHT-DARK TEST; LIPID DIET; LIPID PEROXIDATION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL; SEROTONINERGIC SYSTEM; SUCROSE PREFERENCE TEST; ANIMAL; ANIMAL BEHAVIOR; ANXIETY; BLOOD; BODY WEIGHT; COMPLICATION; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; METABOLISM; MOUSE MUTANT; SYNAPTIC TRANSMISSION;

MUS;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BODY WEIGHT; BRAIN; CITALOPRAM; CORTICOSTERONE; DEPRESSION; DIET, HIGH-FAT; GLUCOSE TOLERANCE TEST; GLUTATHIONE; INSULIN; LEPTIN; MALE; MALONDIALDEHYDE; MICE; MICE, OBESE; OBESITY; ONDANSETRON; OXIDATIVE STRESS; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 84938305476     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.07.004     Document Type: Article

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