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Volumn 285, Issue 5 48-5, 2003, Pages

Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats

Author keywords

Arcuate nucleus; Dorsomedial nucleus; Ghrelin receptor; Leptin receptor; Ventromedial nucleus

Indexed keywords

GHRELIN; INSULIN; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

EID: 0142020848     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00186.2003     Document Type: Article
Times cited : (130)

References (51)
  • 1
    • 0001475715 scopus 로고    scopus 로고
    • Guiding Principles for Research Involving Animals and Human Beings
    • American Physiological Society. Guiding Principles for Research Involving Animals and Human Beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.283
  • 7
    • 0036290228 scopus 로고    scopus 로고
    • Ghrelin, macronutrient intake and dietary preferences in Long-Evans rats
    • Beck B, Musse N, and Stricker-Krongrad A. Ghrelin, macronutrient intake and dietary preferences in Long-Evans rats. Biochem Biophys Res Commun 292: 1031-1035, 2002.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 1031-1035
    • Beck, B.1    Musse, N.2    Stricker-Krongrad, A.3
  • 9
    • 0028928580 scopus 로고
    • Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European Fat Distribution Study
    • Cigolini M, Seidell JC, Targher G, Deslypere JP, Ellsinger BM, Charzewska J, Cruz A, and Bjorntorp P. Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: the European Fat Distribution Study. Metabolism 44: 35-40, 1995.
    • (1995) Metabolism , vol.44 , pp. 35-40
    • Cigolini, M.1    Seidell, J.C.2    Targher, G.3    Deslypere, J.P.4    Ellsinger, B.M.5    Charzewska, J.6    Cruz, A.7    Bjorntorp, P.8
  • 12
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255-4261, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 14
    • 0032041972 scopus 로고    scopus 로고
    • The insulin resistance-dyslipidemic syndrome of visceral obesity: Effect on patients' risk
    • Despres JP. The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. Obes Res 6: 8S-17S, 1998.
    • (1998) Obes Res , vol.6
    • Despres, J.P.1
  • 15
    • 0023248476 scopus 로고
    • Role of autonomic nervous system in postprandial thermogenesis in dogs
    • Diamond P and LeBlanc J. Role of autonomic nervous system in postprandial thermogenesis in dogs. Am J Physiol Endocrinol Metab 252: E719-E726, 1987.
    • (1987) Am J Physiol Endocrinol Metab , vol.252
    • Diamond, P.1    LeBlanc, J.2
  • 16
    • 0031057817 scopus 로고    scopus 로고
    • Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6
    • Dickson SL and Luckman SM. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 138: 771-777, 1997.
    • (1997) Endocrinology , vol.138 , pp. 771-777
    • Dickson, S.L.1    Luckman, S.M.2
  • 18
    • 0036729931 scopus 로고    scopus 로고
    • Fat intake affects adiposity, comorbidity factors, and energy metabolism of Sprague-Dawley rats
    • Ghibaudi L, Cook J, Farley C, Van Heek M, and Hwa JJ. Fat intake affects adiposity, comorbidity factors, and energy metabolism of Sprague-Dawley rats. Obes Res 10: 956-963, 2002.
    • (2002) Obes Res , vol.10 , pp. 956-963
    • Ghibaudi, L.1    Cook, J.2    Farley, C.3    Van Heek, M.4    Hwa, J.J.5
  • 20
    • 0033975409 scopus 로고    scopus 로고
    • Early leptin response to a palatable diet predicts dietary obesity in rats: Key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus
    • Harrold JA, Williams G, and Widdowson PS. Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus. J Neurochem 74: 1224-1228, 2000.
    • (2000) J Neurochem , vol.74 , pp. 1224-1228
    • Harrold, J.A.1    Williams, G.2    Widdowson, P.S.3
  • 21
    • 0036896934 scopus 로고    scopus 로고
    • Fasting ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kanagawa K, and Sugihara S. Fasting ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51: 3408-3411, 2002.
    • (2002) Diabetes , vol.51 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6    Kondo, C.7    Kojima, M.8    Kanagawa, K.9    Sugihara, S.10
  • 22
    • 0032437482 scopus 로고    scopus 로고
    • Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB)
    • Ishizuka T, Ernsberger P, Liu S, Bedol D, Lehman TM, Koletsky RJ, and Friedman JE. Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB). J Nutr 128: 2299-2306, 1998.
    • (1998) J Nutr , vol.128 , pp. 2299-2306
    • Ishizuka, T.1    Ernsberger, P.2    Liu, S.3    Bedol, D.4    Lehman, T.M.5    Koletsky, R.J.6    Friedman, J.E.7
  • 23
    • 0034522843 scopus 로고    scopus 로고
    • Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, and Wakabayashi I. Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology 141: 4797-4800, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4797-4800
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 24
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, and Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 50: 2438-2443, 2001.
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 25
    • 0000348081 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 611: 221-235, 1953.
    • (1953) Proc R Soc Lond B Biol Sci , vol.611 , pp. 221-235
    • Kennedy, G.C.1
  • 26
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 27
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretogogues induce feeding and activate brain appetite centers
    • Lawrence CB, Snape AC, Baudoin FM, and Luckman SM. Acute central ghrelin and GH secretogogues induce feeding and activate brain appetite centers. Endocrinology 143: 155-162, 2002.
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 28
    • 0030938684 scopus 로고    scopus 로고
    • Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats
    • Levin BE and Dunn-Meynell AA. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370, 1997.
    • (1997) Am J Physiol Regul Integr Comp Physiol , vol.272
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 33
  • 35
    • 0031657505 scopus 로고    scopus 로고
    • The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity
    • Lin X, Chavez MR, Bruch RC, Kilroy GE, Simmons LA, Lin L, Braymer HD, Bray GA, and York DA. The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity. J Nutr 128: 1606-1613, 1998.
    • (1998) J Nutr , vol.128 , pp. 1606-1613
    • Lin, X.1    Chavez, M.R.2    Bruch, R.C.3    Kilroy, G.E.4    Simmons, L.A.5    Lin, L.6    Braymer, H.D.7    Bray, G.A.8    York, D.A.9
  • 39
    • 0034853507 scopus 로고    scopus 로고
    • Plasma ghrelin concentration and energy balance: Overfeeding and negative energy balance studies in twins
    • Ravussin E, Tschop M, Morales S, Bouchard C, and Heiman ML. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab 86: 4547-4551, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4547-4551
    • Ravussin, E.1    Tschop, M.2    Morales, S.3    Bouchard, C.4    Heiman, M.L.5
  • 40
    • 0041919296 scopus 로고    scopus 로고
    • Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats
    • Ricci MR and Levin BE. Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 285: R610-R618, 2003.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Ricci, M.R.1    Levin, B.E.2
  • 42
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, and Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232, 2001.
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6    Hayashi, T.7    Inoue, G.8    Hosoda, K.9    Kojima, M.10    Kangawa, K.11    Nakao, K.12
  • 44
    • 0030804112 scopus 로고    scopus 로고
    • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
    • Surwit RS, Petro AE, Parekh P, and Collins S. Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46: 1516-1520, 1997.
    • (1997) Diabetes , vol.46 , pp. 1516-1520
    • Surwit, R.S.1    Petro, A.E.2    Parekh, P.3    Collins, S.4
  • 46
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, and Heiman ML. Ghrelin induces adiposity in rodents. Nature 407: 908-913, 2000.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 48
    • 0035187884 scopus 로고    scopus 로고
    • Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro
    • Tung YC, Hewson AK, and Dickson SL. Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro. J Neuroendocrinol 13: 209-215, 2001.
    • (2001) J Neuroendocrinol , vol.13 , pp. 209-215
    • Tung, Y.C.1    Hewson, A.K.2    Dickson, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.