Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat

Clinical Endocrinology

Volumn 76, Issue 4, 2012, Pages 520-525

  Lawson, Elizabeth A ^a   Miller, Karen K ^a   Blum, Justine I ^a   Meenaghan, Erinne ^a   Misra, Madhusmita ^a   Eddy, Kamryn T ^a   Herzog, David B ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; LEPTIN;

ADULT; AMENORRHEA; ANOREXIA NERVOSA; ANXIETY; ARTICLE; BODY FAT; BODY WEIGHT; CLINICAL ARTICLE; DEPRESSION; DISEASE SEVERITY; FEMALE; HUMAN; OBESITY; PRIORITY JOURNAL; RATING SCALE; RISK FACTOR;

ADIPOSE TISSUE; ADULT; ANOREXIA NERVOSA; BODY MASS INDEX; BODY WEIGHT; CROSS-SECTIONAL STUDIES; DEPRESSION; FASTING; FEMALE; GHRELIN; HUMANS; LEPTIN; OBESITY;

EID: 84857836228     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04182.x     Document Type: Article

References (46)

1. Jequier, E. (2002) Leptin signaling, adiposity, and energy balance. Annals of the New York Academy of Sciences, 967, 379-388.
2. Tschop, M., Weyer, C., Tataranni, P.A. et al. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes, 50, 707-709. (Pubitemid 32242624)
3. Lu, X.Y., Kim, C.S., Frazer, A. et al. (2006) Leptin: a potential novel antidepressant. Proceedings of the National Academy of Sciences of the United States of America, 103, 1593-1598. (Pubitemid 43191210)
4. Liu, J., Garza, J.C., Bronner, J. et al. (2010) Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology, 207, 535-545.
5. Kristenssson, E., Sundqvist, M., Astin, M. et al. (2006) Acute psychological stress raises plasma ghrelin in the rat. Regulatory Peptides, 134, 114-117. (Pubitemid 44287828)
6. Hansson, C., Haage, D., Taube, M. et al. (2011) Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence. Neuroscience, 180, 201-211.
7. Carlini, V.P., Varas, M.M., Cragnolini, A.B. et al. (2004) Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochemical and Biophysical Research Communications, 313, 635-641. (Pubitemid 38021878)
8. Carlini, V.P., Monzón, M.E., Varas, M.M. et al. (2002) Ghrelin increases anxiety-like behavior and memory retention in rats. Biochemical and Biophysical Research Communications, 299, 739-743. (Pubitemid 36034549)
9. Asakawa, A., Inui, A., Kaga, T. et al. (2001) A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology, 74, 143-147. (Pubitemid 32786213)
10. Herzog, D.B., Keller, M.B., Sacks, N.R. et al. (1992) Psychiatric comorbidity in treatment-seeking anorexics and bulimics. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 810-818.
11. Braun, D.L., Sunday, S.R. & Halmi, K.A. (1994) Psychiatric comorbidity in patients with eating disorders. Psychological Medicine, 24, 859-867.
12. Pollice, C., Kaye, W.H., Greeno, C.G. et al. (1997) Relationship of depression, anxiety, and obsessionality to state of illness in anorexia nervosa. International Journal of Eating Disorders, 21, 367-376. (Pubitemid 27184007)
13. Kaye, W.H., Bulik, C.M., Thornton, L. et al. (2004) Comorbidity of anxiety disorders with anorexia and bulimia nervosa. American Journal of Psychiatry, 161, 2215-2221. (Pubitemid 39587286)
14. Grinspoon, S., Gulick, T., Askari, H. et al. (1996) Serum leptin levels in women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 81, 3861-3863. (Pubitemid 26380387)
15. Nakahara, T., Kojima, S., Tanaka, M. et al. (2007) Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa. Journal of Psychiatric Research, 41, 814-820. (Pubitemid 46693895)
16. Misra, M., Miller, K.K., Kuo, K. et al. (2005) Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents. American Journal of Physiology Endocrinology and Metabolism, 289, E347-E356. (Pubitemid 41076638)
17. Fava, G.A., Trombini, G., Grandi, S. et al. (1984) Depression and anxiety associated with secondary amenorrhea. Psychosomatics, 25, 905-908. (Pubitemid 15154312)
18. Warren, M.P., Voussoughian, F., Geer, E.B. et al. (1999) Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. Journal of Clinical Endocrinology and Metabolism, 84, 873-877. (Pubitemid 29138211)
19. Miller, K.K., Parulekar, M.S., Schoenfeld, E. et al. (1998) Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. Journal of Clinical Endocrinology and Metabolism, 83, 2309-2312. (Pubitemid 28503019)
20. Schneider, L.F., Monaco, S.E. & Warren, M.P. (2008) Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating. Fertility and Sterility, 90, 121-128. (Pubitemid 351885190)
21. Gariepy, G., Nitka, D. & Schmitz, N. (2010) The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. International Journal of Obesity, 34, 407-419.
22. Luppino, F.S., de Wit, L.M., Bouvy, P.F. et al. (2010) Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Archives of General Psychiatry, 67, 220-229.
23. Lawson, E.A., Donoho, D., Miller, K.K. et al. (2009) Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 94, 4710-4716.
24. Lawson, E.A., Eddy, K.T., Donoho, D. et al. (2011) Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index. European Journal of Endocrinology, 164, 253-261.
25. Lawson, E.A., Donoho, D., Blum, J. et al. (2011) Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass. Journal of Clinical Psychiatry. In Press.
26. Frisancho, A.R. & Flegel, P.N. (1983) Elbow breadth as a measure of frame size for US males and females. American Journal of Clinical Nutrition, 37, 311-314. (Pubitemid 13130707)
27. Mazess, R.B., Barden, H.S., Bisek, J.P. et al. (1990) Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. American Journal of Clinical Nutrition, 51, 1106-1112.
28. Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56-62.
29. Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50-55.
30. Cohen, S. & Williamson, G.M. (1988) Perceived stress in a probability sample of the United States. In: S. Spacapan, S. Oskamp eds. The Social Psychology of Health. Sage, Newbury Park, CA, 31-67.
31. Zimmerman, M., Chelminski, I. & Posternak, M. (2004) A review of studies of the Hamilton depression rating scale in healthy controls: implications for the definition of remission in treatment studies of depression. The Journal of Nervous and Mental Disease, 192, 595-601. (Pubitemid 39238406)
32. Yamada, N., Katsuura, G., Ochi, Y. et al. (2011) Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology, 152, 2634-2643.
33. Finger, B.C., Dinan, T.G. & Cryan, J.F. (2010) Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours. Psychopharmacology, 210, 559-568.
34. Liu, J., Perez, S.M., Zhang, W. et al. (2011) Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala. Molecular Psychiatry, 16, 1024-1038.
35. Kauffman, R.P., Castracane, V.D., White, D.L. et al. (2005) Impact of the selective serotonin reuptake inhibitor citalopram on insulin sensitivity, leptin and basal cortisol secretion in depressed and nondepressed euglycemic women of reproductive age. Gynecological Endocrinology, 21, 129-137. (Pubitemid 41597553)
36. Kraus, T., Haack, M., Schuld, A. et al. (2001) Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology, 73, 243-247. (Pubitemid 32424518)
37. Jow, G.M., Yang, T.T. & Chen, C.L. (2006) Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. Journal of Affective Disorders, 90, 21-27.
38. Yang, K., Xie, G., Zhang, Z. et al. (2007) Levels of serum interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha and leptin and their correlation in depression. Australian and New Zealand Journal of Psychiatry, 41, 266-273. (Pubitemid 46705742)
39. Antonijevic, I.A., Murck, H., Frieboes, R.M. et al. (1998) Elevated nocturnal profiles of serum leptin in patients with depression. Journal of Psychiatric Research, 32, 403-410. (Pubitemid 28491246)
40. Pasco, J.A., Jacka, F.N., Williams, L.J. et al. (2008) Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study. Journal of Affective Disorders, 107, 221-225. (Pubitemid 351288908)
41. Brunetti, L., Recinella, L., Orlando, G. et al. (2002) Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. European Journal of Pharmacology, 454, 189-192. (Pubitemid 35287478)
42. Carlini, V.P., Gaydou, R.C., Schioth, H.B. et al. (2007) Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake. Regulatory Peptides, 140, 65-73.
43. Schanze, A., Reulbach, U., Scheuchenzuber, M. et al. (2008) Ghrelin and eating disturbances in psychiatric disorders. Neuropsychobiology, 57, 126-130.
44. Kluge, M., Schussler, P., Schmid, D. et al. (2009) Ghrelin plasma levels are not altered in major depression. Neuropsychobiology, 59, 199-204.
45. Olszanecka-Glinianowicz, M., Kocelak, P., Wikarek, T. et al. (2010) Are plasma ghrelin and PYY concentrations associated with obesity-related depression? Endokrynologia Polska, 61, 174-177.
46. Hosoda, H., Doi, K., Nagaya, N. et al. (2004) Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clinical Chemistry, 50, 1077-1080. (Pubitemid 38725803)