Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels

European Neuropsychopharmacology

Volumn 23, Issue 7, 2013, Pages 653-662

  Kloiber, Stefan ^a   Ripke, Stephan ^b   Kohli, Martin A ^c   Reppermund, Simone ^d   Salyakina, Daria ^c   Uher, Rudolf ^e   McGuffin, Peter ^e   Perlis, Roy H ^b   Hamilton, Steven P ^f   Pütz, Benno ^a   Hennings, Johannes ^a   Brückl, Tanja ^a   Klengel, Torsten ^a   Bettecken, Thomas ^a   Ising, Marcus ^a   Uhr, Manfred ^a   Dose, Tatjana ^a   Unschuld, Paul G ^g   Zihl, Josef ^a   Binder, Elisabeth ^a   Müller Myhsok, Bertram ^a   Holsboer, Florian ^a   Lucae, Susanne ^a   more..

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Depression; Gene expression; Leptin; Pharmacogenetics; Treatment response

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; LEPTIN; MESSENGER RNA; MIRTAZAPINE; MOOD STABILIZER; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; BIPOLAR DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE REPLICATION; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HOSPITAL PATIENT; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL PATIENT; META ANALYSIS (TOPIC); MONOTHERAPY; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REMISSION; RISK FACTOR; SERUM; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIDEPRESSIVE AGENTS; COGNITION; DATABASES, GENETIC; DEPRESSION; DRUG RESISTANCE; FEMALE; GENE EXPRESSION; HUMANS; LEPTIN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; TREATMENT OUTCOME;

EID: 84878831821     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.08.010     Document Type: Article

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