Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models

Neuropharmacology

Volumn 99, Issue , 2015, Pages 187-195

  Buendia, Izaskun ^a,b   Gómez Rangel, Vanessa ^a,b   González Lafuente, Laura ^a,b   Parada, Esther ^a,b   León, Rafael ^a,b,c   Gameiro, Isabel ^a,b,c   Michalska, Patrycja ^a,b,c   Laudon, Moshe ^d   Egea, Javier ^a,b,c   López, Manuela G ^a,b  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas   (Spain)

^d NEURIM PHARMACEUTICALS LTD   (Israel)

Author keywords

Brain ischemia; In vitro; In vivo; JAK2 AKT ERK1 2; Neu P11; Neuroprotection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOSE; GLUTAMIC ACID; JANUS KINASE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PIROMELATINE; PROTEIN KINASE B; STAT PROTEIN; ANTIOXIDANT; INDOLE DERIVATIVE; MELATONIN; MELATONIN RECEPTOR; N-(2-(5-METHOXY-INDOL-3-YL)-ETHYL)-4-OXO-4H-PYRAN-2-CARBOXAMIDE; NEUROPROTECTIVE AGENT; PYRAN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXCITOTOXICITY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; SH SY5Y CELL LINE; WESTERN BLOTTING; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; CELL HYPOXIA; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; RANDOMIZATION; SPRAGUE DAWLEY RAT; TISSUE CULTURE TECHNIQUE; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GLUCOSE; HUMANS; INDOLES; MALE; MELATONIN; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PYRANS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, MELATONIN; TISSUE CULTURE TECHNIQUES;

EID: 84938261747     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.07.014     Document Type: Article

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