Melatonin attenuates the cerebral ischemic injury via the MEK/ERK/p90RSK/Bad signaling cascade

Journal of Veterinary Medical Science

Volumn 70, Issue 11, 2008, Pages 1219-1223

  Koh, Phil Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

ERK; MEK; Melatonin; Neuroprotection; P90RSK

Indexed keywords

MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN BAD; S6 KINASE;

ANIMAL; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; DRUG EFFECT; ENZYMOLOGY; HEMISPHERIC DOMINANCE; MALE; METABOLISM; NICK END LABELING; PATHOLOGY; PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN INJURIES; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL INFARCTION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FUNCTIONAL LATERALITY; IN SITU NICK-END LABELING; MALE; MAP KINASE KINASE 1; MELATONIN; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

ANIMALIA; RATTUS;

EID: 57349170749     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.70.1219     Document Type: Article

References (24)

1. Andrabi, S. A., Sayeed, I., Siemen, D., Wolf, G. and Horn, T. F. 2004. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J. 18: 869-871.
2. Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A. and Greenberg M. E. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362.
3. Cuzzocrea, S., Costantino, G., Gitto, E., Mazzon, E., Fulia, F., Serraino, I., Cordaro, S., Barberi, I., De Sarro, A. and Caputi, A.P. 2000. Protective effects of melatonin in ischemic brain injury. J. Pineal Res. 29: 217-227.
4. Frodin, M. and Gammeltoft, S. 1999. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell Endocrinol. 151: 65-77.
5. Jou, M. J., Peng, T. I., Reiter, R .J., Jou, S. B., Wu, H. Y. and Wen, S. T. 2004. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J. Pineal Res. 37: 55-70.
6. Kilic, E., Kilic, U., Yulug, B., Hermann, D. M. and Reiter, R. J. 2004. Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. J. Pineal Res. 36: 171-176.
7. Kilic, U., Kilic, E., Reiter, R. J., Bassetti, C. L. and Hermann, D. M. 2005. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J. Pineal Res. 38: 67-71.
8. Koh, P. O. 2008. Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. J. Pineal Res. 44: 101-106.
9. Koh, P. O. 2008. Melatonin prevents the injury-induced decline of Akt/forkhead transcription factors phosphorylation. J. Pineal Res. 45: 199-203.
10. Longa, E. Z., Weinstein, P. R., Carlson, S. and Cummins, R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91.
11. Maldonado, M. D., Murillo-Cabezas, F., Terron, M. P., Flores, L. J., Tan, D. X., Manchester, L. C. and Reiter, R. J. 2007. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J. Pineal Res. 42: 1-11.
12. Manda, K., Ueno, M. and Anzai, K. 2007. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J. Pineal Res. 42: 386-393.
13. Nomura, M., Shimizu, S., Sugiyama, T., Narita, M., Ito, T., Matsuda, H. and Tsujimoto, Y. 2003. 14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax. J. Biol. Chem. 278: 2058-2065.
14. Oliver, F. J., de la Rubia, G., Rolli, V., Ruiz-Ruiz, M. C., de Murcia, G. and Murcia, J. M. 1998. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J. Biol. Chem. 273: 33533-33539.
15. Pearson, G., Robinson, F., Gibson, T., Xu, B. E., Karandikar, M., Berman, K. and Cobb, M. H. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22: 153-183.
16. Pei, Z., Pang, S. F. and Cheung, R. T. 2002. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. J. Pineal Res. 32: 168-172.
17. Pei, Z. and Cheung, R. T. 2004. Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. J. Pineal Res. 37: 85-91.
18. Roy, D. and Belsham, D. D. 2002. Melatonin receptor activation regulates GnRH gene expression and secretion in GT1-7 GnRH neurons. Signal transduction mechanisms. J. Biol. Chem. 277: 251-258.
19. Satoh, M. S. and Lindahl, T. 1992. Role of poly (ADP-ribose) formation in DNA repair. Nature 356: 356-358.
20. Shimamura, A., Ballif, B. A., Richards, S. A. and Blenis, J. 2000. Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr. Biol. 10: 127-135.
21. Tan, D. X., Manchester, L. C., Terron, M. P., Flores, L. J. and Reiter, R. J. 2007. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 42: 28-42.
22. Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B. and Korsmeyer, S. J. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-291.
23. Yoshimoto, T., Uchino, H., He, Q. P., Li, P. A. and Siesjo, B. K. 2001. Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. Brain Res. 899: 148-158.
24. Zha, J., Harada, H., Yang, E., Jockel, J. and Korsmeyer, S. J. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-x(L). Cell 87: 619-628.