Mitochondrial genome sequencing of chondrocytes in osteoarthritis by human mitochondria RT2 Profiler™ PCR array

Molecular Medicine Reports

Volumn 6, Issue 1, 2012, Pages 39-44

  Li, Zhifu ^a,b   Shen, Jun ^a   Chen, Yuxian ^a   Pan, Janying ^a   Zeng, Hua ^a   Fang, Hang ^a   Ye, Zhiqiang ^a   Zeng, Chun ^a   Zhang, Rongkai ^a   Cai, Daozhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Chondrocyte; Mitochondrial gene; Osteoarthritis; p53 upregulated modulator of apoptosis; PCR array

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PROTEIN P53; PUMA PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BB3 GENE; BCL2 GENE; BCL2L1 GENE; CALCIFICATION; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CATABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; COX18 GENE; CPT1B GENE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNAJC19 GENE; DOWN REGULATION; FEMALE; FXC1 GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE SEQUENCE; HOMEOSTASIS; HUMAN; HUMAN CELL; LRPPRC GENE; MALE; MFN2 GENE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL FISSION; MITOCHONDRIAL FUSION; MITOCHONDRIAL GENOME; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TARGETING SIGNAL; NEFL GENE; NEOPLASM; OSTEOARTHRITIS; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PMPAIP1 GENE; POLARIZATION; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; SLC25A10 GENE; SLC25A12 GENE; SLC25A16 GENE; SLC25A2 GENE; SLC25A24 GENE; SLC25A31 GENE; SLC25A37 GENE; SLCA22 GENE; SLCA25 GENE; STARD3 GENE; TIMM17B GENE; TP53 GENE; UCP1 GENE; UCP3 GENE; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS REGULATORY PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, MITOCHONDRIAL; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, DNA;

EID: 84861589869     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.863     Document Type: Article

References (31)

1. Aigner T and McKenna L: Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 59: 5-18, 2002. (Pubitemid 34117351)
2. Kim HA and Blanco FJ: Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets 8: 333-345, 2007.
3. Ruiz-Romero C, López-Armada MJ and Blanco FJ: Proteomic characterization of human normal articular chondrocytes: a novel tool for the study of osteoarthritis and other rheumatic diseases. Proteomics 5: 3048-3059, 2005. (Pubitemid 41176471)
4. Goldring MB: The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43: 1916-1926, 2000.
5. Aigner T, Kurz B, Fukui N and Sandell L: Roles of chondrocytes in the pathogenesis of osteoarthritis. Curr Opin Rheumatol 14: 578-584, 2002. (Pubitemid 34953799)
6. Carr AJ: Beyond disability: measuring the social and personal consequences of osteoarthritis. Osteoarthritis Cartilage 7: 230-238, 1999.
7. Roti G and Stegmaier K: Genetic and proteomic approaches to identify cancer drug targets. Br J Cancer 106: 254-261, 2012.
8. Herder C, Karakas M and Koenig W: Biomarkers for the prediction of type 2 diabetes and cardiovascular disease. Clin Pharmacol Ther 90: 52-66, 2011.
9. Wojewoda M, Zabłocki K and Szczepanowska J: Diseases caused by mutations in mitochondrial DNA. Postepy Biochem 57: 222-229, 2011.
10. Zeviani M, Simonati A and Bindoff LA: Ataxia in mitochondrial disorders. Handb Clin Neurol 103: 359-372,2012.
11. Blanco FJ, Rego I and Ruiz-Romero C: The role of mitochondria in osteoarthritis. Nat Rev Rheumatol 7: 161-169, 2011.
12. Ruiz-Romero C, Calamia V, Mateos J, Carreira V, Martínez-Gomariz M, Fernández M and Blanco FJ: Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics a decrease in mitochondrial superoxide dismutase points to a redox imbalance. Mol Cell Proteomics 8: 172-189, 2009.
13. Kouri JB and Lavalle C: Do chondrocytes undergo 'activation'and 'transdifferentiation' during the pathogenesis of osteoarthritis? A review of the ultrastructural and immunohistochemical evidence. Histol Histopathol 21: 793-802, 2006.
14. Sandell LJ and Aigner T: Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3: 107-113, 2001. (Pubitemid 32237037)
15. Blanco FJ, Guitian R, Vázquez-Martul E, de Toro FJ and Galdo F: Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41: 284-289, 1998. (Pubitemid 28087696)
16. Kim DY, Taylor HW, Moore RM, Paulsen DB and Cho DY: Articular chondrocyte apoptosis in equine osteoarthritis. Vet J 166: 52-57, 2003. (Pubitemid 37554985)
17. Adams CS and Horton WE Jr: Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 250: 418-425, 1998. (Pubitemid 28180432)
18. Kim HA, Lee YJ, Seong SC, Choe KW and Song YW: Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 27: 455-462, 2000. (Pubitemid 30095481)
19. Jeffers JR, Parganas E, Lee Y, et al: PUMA is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328, 2003. (Pubitemid 37329796)
20. Shaltouki A, Freer M, Mei Y and Weyman CM: Increased expression of the pro-apoptotic Bcl(2) family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis 12: 2143-2154, 2007. (Pubitemid 350077249)
21. Day CL, Smits C, Fan FC, Lee EF, Fairlie WD and Hinds MG: Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol 380: 958-971, 2008.
22. Nakano K and Vousden KH: PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694, 2001. (Pubitemid 32706359)
23. Wang P, Yu J and Zhang L: The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci USA 104: 4054-4059, 2007. (Pubitemid 47181577)
24. Tsuruya K, Yotsueda H, Ikeda H, Taniguchi M, Masutani K, Hayashida H, Hirakata H and Iida M: Involvement of p53-transactivated Puma in cisplatin-induced renal tubular cell death. Life Sci 83: 550-556, 2008.
25. Johnson K, Svensson CI, Etten DV, Ghosh SS, Murphy AN, Powell HC and Terkeltaub R: Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum 50: 1216-1225, 2004. (Pubitemid 38480832)
26. Henrotin YE, Bruckner P and Pujol JP: The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11: 747-755, 2003. (Pubitemid 37184493)
27. Afonso V, Champy R, Mitrovic D, Collin P and Lomri A: Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine 74: 324-329, 2007. (Pubitemid 47049827)
28. Li YZ, Lu DY, Tan WQ, Wang JX and Li PF: P53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol Cell Biol 28: 564-574, 2008.
29. Steckley D, Karajgikar M, Dale LB, Fuerth B, Swan P, Drummond-Main C, Poulter MO, Ferguson SS, Strasser A and Cregan SP: Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27: 12989-12999, 2007. (Pubitemid 350159577)
30. Liu Z, Lu H, Shi H, Du Y, Yu J, Gu S, Chen X, Liu KJ and Hu CA: PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Cancer Res 65: 1647-1654, 2005. (Pubitemid 40478588)
31. Henrotin Y and Kurz B: Antioxidant to treat osteoarthritis: dream or reality? Curr Drug Targets 8: 347-357, 2007.