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Volumn 569, Issue 2, 2015, Pages 162-172

The KCNE2 K+ channel regulatory subunit: Ubiquitous influence, complex pathobiology

Author keywords

Cardiac arrhythmia; Potassium channel; Sudden cardiac death; Thyroid; Transporter

Indexed keywords

POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNQ1; KCNE2 PROTEIN, HUMAN; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 84937974780     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2015.06.061     Document Type: Review
Times cited : (43)

References (89)
  • 1
    • 84860335532 scopus 로고    scopus 로고
    • + channel: the tail wagging the dog
    • + channel: the tail wagging the dog. Channels (Austin) 2012, 6(1).
    • (2012) Channels (Austin)
    • Abbott, G.W.1
  • 2
    • 84923274013 scopus 로고    scopus 로고
    • Biology of the KCNQ1 potassium channel
    • Abbott G.W. Biology of the KCNQ1 potassium channel. New J. Sci. 2014, 2014.
    • (2014) New J. Sci. , vol.2014
    • Abbott, G.W.1
  • 3
    • 0032304724 scopus 로고    scopus 로고
    • A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs)
    • Abbott G.W., Goldstein S.A. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q. Rev. Biophys. 1998, 31(4):357-398.
    • (1998) Q. Rev. Biophys. , vol.31 , Issue.4 , pp. 357-398
    • Abbott, G.W.1    Goldstein, S.A.2
  • 4
    • 0033574273 scopus 로고    scopus 로고
    • MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
    • Abbott G.W., Sesti F., Splawski I., Buck M.E., Lehmann M.H., Timothy K.W., et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999, 97(2):175-187.
    • (1999) Cell , vol.97 , Issue.2 , pp. 175-187
    • Abbott, G.W.1    Sesti, F.2    Splawski, I.3    Buck, M.E.4    Lehmann, M.H.5    Timothy, K.W.6
  • 6
    • 0345690174 scopus 로고    scopus 로고
    • Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome
    • Ackerman M.J., Tester D.J., Jones G.S., Will M.L., Burrow C.R., Curran M.E. Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. Mayo Clin. Proc.Mayo Clin. 2003, 78(12):1479-1487.
    • (2003) Mayo Clin. Proc.Mayo Clin. , vol.78 , Issue.12 , pp. 1479-1487
    • Ackerman, M.J.1    Tester, D.J.2    Jones, G.S.3    Will, M.L.4    Burrow, C.R.5    Curran, M.E.6
  • 7
    • 0034598810 scopus 로고    scopus 로고
    • Modulation of A-type potassium channels by a family of calcium sensors
    • An W.F., Bowlby M.R., Betty M., Cao J., Ling H.P., Mendoza G., et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 2000, 403(6769):553-556.
    • (2000) Nature , vol.403 , Issue.6769 , pp. 553-556
    • An, W.F.1    Bowlby, M.R.2    Betty, M.3    Cao, J.4    Ling, H.P.5    Mendoza, G.6
  • 8
    • 0242410971 scopus 로고    scopus 로고
    • Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kvbeta subunits
    • Bahring R., Milligan C.J., Vardanyan V., Engeland B., Young B.A., Dannenberg J., et al. Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kvbeta subunits. J. Biol. Chem. 2001, 276(25):22923-22929.
    • (2001) J. Biol. Chem. , vol.276 , Issue.25 , pp. 22923-22929
    • Bahring, R.1    Milligan, C.J.2    Vardanyan, V.3    Engeland, B.4    Young, B.A.5    Dannenberg, J.6
  • 10
    • 22544475622 scopus 로고    scopus 로고
    • In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart
    • Bendahhou S., Marionneau C., Haurogne K., Larroque M.M., Derand R., Szuts V., et al. In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart. Cardiovasc. Res. 2005, 67(3):529-538.
    • (2005) Cardiovasc. Res. , vol.67 , Issue.3 , pp. 529-538
    • Bendahhou, S.1    Marionneau, C.2    Haurogne, K.3    Larroque, M.M.4    Derand, R.5    Szuts, V.6
  • 11
    • 70450253100 scopus 로고    scopus 로고
    • Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels
    • Bocksteins E., Labro A.J., Mayeur E., Bruyns T., Timmermans J.P., Adriaensen D., et al. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. J. Biol. Chem. 2009, 284(46):31625-31634.
    • (2009) J. Biol. Chem. , vol.284 , Issue.46 , pp. 31625-31634
    • Bocksteins, E.1    Labro, A.J.2    Mayeur, E.3    Bruyns, T.4    Timmermans, J.P.5    Adriaensen, D.6
  • 12
    • 0021330126 scopus 로고
    • The molecular basis of neuronal excitability
    • Catterall W.A. The molecular basis of neuronal excitability. Science 1984, 223(4637):653-661.
    • (1984) Science , vol.223 , Issue.4637 , pp. 653-661
    • Catterall, W.A.1
  • 14
    • 84893688099 scopus 로고    scopus 로고
    • Arrhythmogenic KCNE gene variants: current knowledge and future challenges
    • Crump S.M., Abbott G.W. Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Front. Genet. 2014, 5:3.
    • (2014) Front. Genet. , vol.5 , pp. 3
    • Crump, S.M.1    Abbott, G.W.2
  • 15
    • 0028914969 scopus 로고
    • A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
    • Curran M.E., Splawski I., Timothy K.W., Vincent G.M., Green E.D., Keating M.T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995, 80(5):795-803.
    • (1995) Cell , vol.80 , Issue.5 , pp. 795-803
    • Curran, M.E.1    Splawski, I.2    Timothy, K.W.3    Vincent, G.M.4    Green, E.D.5    Keating, M.T.6
  • 16
    • 0034802582 scopus 로고    scopus 로고
    • Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract
    • Dedek K., Waldegger S. Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. Pflugers Arch. - Eur. J. Physiol. 2001, 442(6):896-902.
    • (2001) Pflugers Arch. - Eur. J. Physiol. , vol.442 , Issue.6 , pp. 896-902
    • Dedek, K.1    Waldegger, S.2
  • 18
    • 84873828284 scopus 로고    scopus 로고
    • Molecular and genetic basis of sudden cardiac death
    • George A.L. Molecular and genetic basis of sudden cardiac death. J. Clin. Invest. 2013, 123(1):75-83.
    • (2013) J. Clin. Invest. , vol.123 , Issue.1 , pp. 75-83
    • George, A.L.1
  • 19
    • 33646814436 scopus 로고    scopus 로고
    • KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin
    • Ghosh S., Nunziato D.A., Pitt G.S. KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circ. Res. 2006, 98(8):1048-1054.
    • (2006) Circ. Res. , vol.98 , Issue.8 , pp. 1048-1054
    • Ghosh, S.1    Nunziato, D.A.2    Pitt, G.S.3
  • 20
  • 21
    • 38849147117 scopus 로고    scopus 로고
    • A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance
    • Gordon E., Panaghie G., Deng L., Bee K.J., Roepke T.K., Krogh-Madsen T., et al. A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc. Res. 2008, 77(1):98-106.
    • (2008) Cardiovasc. Res. , vol.77 , Issue.1 , pp. 98-106
    • Gordon, E.1    Panaghie, G.2    Deng, L.3    Bee, K.J.4    Roepke, T.K.5    Krogh-Madsen, T.6
  • 24
    • 10644247765 scopus 로고    scopus 로고
    • Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells
    • Heitzmann D., Grahammer F., von Hahn T., Schmitt-Graff A., Romeo E., Nitschke R., et al. Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J. Physiol. 2004, 561(Pt 2):547-557.
    • (2004) J. Physiol. , vol.561 , pp. 547-557
    • Heitzmann, D.1    Grahammer, F.2    von Hahn, T.3    Schmitt-Graff, A.4    Romeo, E.5    Nitschke, R.6
  • 26
    • 0032853087 scopus 로고    scopus 로고
    • Ion channels: from idea to reality
    • Hille B., Armstrong C.M., MacKinnon R. Ion channels: from idea to reality. Nat. Med. 1999, 5(10):1105-1109.
    • (1999) Nat. Med. , vol.5 , Issue.10 , pp. 1105-1109
    • Hille, B.1    Armstrong, C.M.2    MacKinnon, R.3
  • 27
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • Hodgkin A.L., Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 1952, 117(4):500-544.
    • (1952) J. Physiol. , vol.117 , Issue.4 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 29
    • 0036377042 scopus 로고    scopus 로고
    • Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics
    • Isbrandt D., Friederich P., Solth A., Haverkamp W., Ebneth A., Borggrefe M., et al. Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics. J. Mol. Med. (Berl.) 2002, 80(8):524-532.
    • (2002) J. Mol. Med. (Berl.) , vol.80 , Issue.8 , pp. 524-532
    • Isbrandt, D.1    Friederich, P.2    Solth, A.3    Haverkamp, W.4    Ebneth, A.5    Borggrefe, M.6
  • 32
    • 80053105505 scopus 로고    scopus 로고
    • KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels
    • Kanda V.A., Lewis A., Xu X., Abbott G.W. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys. J. 2011, 101(6):1354-1363.
    • (2011) Biophys. J. , vol.101 , Issue.6 , pp. 1354-1363
    • Kanda, V.A.1    Lewis, A.2    Xu, X.3    Abbott, G.W.4
  • 33
    • 80053120343 scopus 로고    scopus 로고
    • KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel alpha-subunit composition
    • Kanda V.A., Lewis A., Xu X., Abbott G.W. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel alpha-subunit composition. Biophys. J. 2011, 101(6):1364-1375.
    • (2011) Biophys. J. , vol.101 , Issue.6 , pp. 1364-1375
    • Kanda, V.A.1    Lewis, A.2    Xu, X.3    Abbott, G.W.4
  • 34
    • 80053050919 scopus 로고    scopus 로고
    • Ks by stimulating KCNQ1-KCNE1 potassium channel endocytosis
    • Ks by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm. 2011, 8(10):1641-1647.
    • (2011) Heart Rhythm. , vol.8 , Issue.10 , pp. 1641-1647
    • Kanda, V.A.1    Purtell, K.2    Abbott, G.W.3
  • 35
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Kathiresan S., Voight B.F., Purcell S., Musunuru K., Ardissino D., Mannucci P.M., et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 2009, 41(3):334-341.
    • (2009) Nat. Genet. , vol.41 , Issue.3 , pp. 334-341
    • Kathiresan, S.1    Voight, B.F.2    Purcell, S.3    Musunuru, K.4    Ardissino, D.5    Mannucci, P.M.6
  • 37
    • 84874628548 scopus 로고    scopus 로고
    • Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression
    • Kuwahara N., Kitazawa R., Fujiishi K., Nagai Y., Haraguchi R., Kitazawa S. Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression. World J. Gastroenterol. 2013, 19(8):1314-1317.
    • (2013) World J. Gastroenterol. , vol.19 , Issue.8 , pp. 1314-1317
    • Kuwahara, N.1    Kitazawa, R.2    Fujiishi, K.3    Nagai, Y.4    Haraguchi, R.5    Kitazawa, S.6
  • 38
    • 0034518479 scopus 로고    scopus 로고
    • Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice
    • Lee M.P., Ravenel J.D., Hu R.J., Lustig L.R., Tomaselli G., Berger R.D., et al. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J. Clin. Invest. 2000, 106(12):1447-1455.
    • (2000) J. Clin. Invest. , vol.106 , Issue.12 , pp. 1447-1455
    • Lee, M.P.1    Ravenel, J.D.2    Hu, R.J.3    Lustig, L.R.4    Tomaselli, G.5    Berger, R.D.6
  • 40
    • 0025762715 scopus 로고
    • Determination of the subunit stoichiometry of a voltage-activated potassium channel
    • MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 1991, 350(6315):232-235.
    • (1991) Nature , vol.350 , Issue.6315 , pp. 232-235
    • MacKinnon, R.1
  • 42
    • 0030872366 scopus 로고    scopus 로고
    • A minK-HERG complex regulates the cardiac potassium current I(Kr)
    • McDonald T.V., Yu Z., Ming Z., Palma E., Meyers M.B., Wang K.W., et al. A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature 1997, 388(6639):289-292.
    • (1997) Nature , vol.388 , Issue.6639 , pp. 289-292
    • McDonald, T.V.1    Yu, Z.2    Ming, Z.3    Palma, E.4    Meyers, M.B.5    Wang, K.W.6
  • 45
    • 0035940747 scopus 로고    scopus 로고
    • + channel function in mice: what have we learned, and where do we go from here?
    • + channel function in mice: what have we learned, and where do we go from here?. Circ. Res. 2001, 89(11):944-956.
    • (2001) Circ. Res. , vol.89 , Issue.11 , pp. 944-956
    • Nerbonne, J.M.1    Nichols, C.G.2    Schwarz, T.L.3    Escande, D.4
  • 46
    • 0036080442 scopus 로고    scopus 로고
    • Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle
    • Ohya S., Asakura K., Muraki K., Watanabe M., Imaizumi Y. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 282(2):G277-G287.
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.282 , Issue.2 , pp. G277-G287
    • Ohya, S.1    Asakura, K.2    Muraki, K.3    Watanabe, M.4    Imaizumi, Y.5
  • 47
    • 33745169339 scopus 로고    scopus 로고
    • The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels
    • Panaghie G., Abbott G.W. The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr. Pharm. Des. 2006, 12(18):2285-2302.
    • (2006) Curr. Pharm. Des. , vol.12 , Issue.18 , pp. 2285-2302
    • Panaghie, G.1    Abbott, G.W.2
  • 48
    • 0023225798 scopus 로고
    • Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
    • Papazian D.M., Schwarz T.L., Tempel B.L., Jan Y.N., Jan L.Y. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science 1987, 237(4816):749-753.
    • (1987) Science , vol.237 , Issue.4816 , pp. 749-753
    • Papazian, D.M.1    Schwarz, T.L.2    Tempel, B.L.3    Jan, Y.N.4    Jan, L.Y.5
  • 49
    • 22144490216 scopus 로고    scopus 로고
    • Posttranslational control of a cardiac ion channel transgene in vivo: clarithromycin-hMiRP1-Q9E interactions
    • Perlstein I., Burton D.Y., Ryan K., Defelice S., Simmers E., Campbell B., et al. Posttranslational control of a cardiac ion channel transgene in vivo: clarithromycin-hMiRP1-Q9E interactions. Hum. Gene Ther. 2005, 16(7):906-910.
    • (2005) Hum. Gene Ther. , vol.16 , Issue.7 , pp. 906-910
    • Perlstein, I.1    Burton, D.Y.2    Ryan, K.3    Defelice, S.4    Simmers, E.5    Campbell, B.6
  • 50
    • 0033568148 scopus 로고    scopus 로고
    • KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs
    • Piccini M., Vitelli F., Seri M., Galietta L.J., Moran O., Bulfone A., et al. KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs. Genomics 1999, 60(3):251-257.
    • (1999) Genomics , vol.60 , Issue.3 , pp. 251-257
    • Piccini, M.1    Vitelli, F.2    Seri, M.3    Galietta, L.J.4    Moran, O.5    Bulfone, A.6
  • 51
    • 84898033564 scopus 로고    scopus 로고
    • Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits
    • Plant L.D., Xiong D., Dai H., Goldstein S.A. Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(14):E1438-E1446.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.14 , pp. E1438-E1446
    • Plant, L.D.1    Xiong, D.2    Dai, H.3    Goldstein, S.A.4
  • 54
    • 79953247377 scopus 로고    scopus 로고
    • Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?
    • Rice K.S., Dickson G., Lane M., Crawford J., Chung S.K., Rees M.I., et al. Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?. Heart Rhythm. 2011, 8(4):551-554.
    • (2011) Heart Rhythm. , vol.8 , Issue.4 , pp. 551-554
    • Rice, K.S.1    Dickson, G.2    Lane, M.3    Crawford, J.4    Chung, S.K.5    Rees, M.I.6
  • 55
    • 33747723381 scopus 로고    scopus 로고
    • The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion
    • Roepke T.K., Anantharam A., Kirchhoff P., Busque S.M., Young J.B., Geibel J.P., et al. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J. Biol. Chem. 2006, 281(33):23740-23747.
    • (2006) J. Biol. Chem. , vol.281 , Issue.33 , pp. 23740-23747
    • Roepke, T.K.1    Anantharam, A.2    Kirchhoff, P.3    Busque, S.M.4    Young, J.B.5    Geibel, J.P.6
  • 57
    • 70350572844 scopus 로고    scopus 로고
    • Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
    • Roepke T.K., King E.C., Reyna-Neyra A., Paroder M., Purtell K., Koba W., et al. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat. Med. 2009, 15(10):1186-1194.
    • (2009) Nat. Med. , vol.15 , Issue.10 , pp. 1186-1194
    • Roepke, T.K.1    King, E.C.2    Reyna-Neyra, A.3    Paroder, M.4    Purtell, K.5    Koba, W.6
  • 58
    • 77955389661 scopus 로고    scopus 로고
    • Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia
    • Roepke T.K., Purtell K., King E.C., La Perle K.M., Lerner D.J., Abbott G.W. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS ONE 2010, 5(7):e11451.
    • (2010) PLoS ONE , vol.5 , Issue.7 , pp. e11451
    • Roepke, T.K.1    Purtell, K.2    King, E.C.3    La Perle, K.M.4    Lerner, D.J.5    Abbott, G.W.6
  • 60
    • 82655181508 scopus 로고    scopus 로고
    • KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium
    • Roepke T.K., Kanda V.A., Purtell K., King E.C., Lerner D.J., Abbott G.W. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011, 25(12):4264-4273.
    • (2011) FASEB J. , vol.25 , Issue.12 , pp. 4264-4273
    • Roepke, T.K.1    Kanda, V.A.2    Purtell, K.3    King, E.C.4    Lerner, D.J.5    Abbott, G.W.6
  • 61
    • 84905438148 scopus 로고    scopus 로고
    • Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease
    • Sabater-Lleal M., Malarstig A., Folkersen L., Soler Artigas M., Baldassarre D., Kavousi M., et al. Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease. PLoS ONE 2014, 9(8):e104082.
    • (2014) PLoS ONE , vol.9 , Issue.8 , pp. e104082
    • Sabater-Lleal, M.1    Malarstig, A.2    Folkersen, L.3    Soler Artigas, M.4    Baldassarre, D.5    Kavousi, M.6
  • 62
    • 84919497481 scopus 로고    scopus 로고
    • Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia
    • (1053-8 e1)
    • Salsbury G., Cambridge E.L., McIntyre Z., Arends M.J., Karp N.A., Isherwood C., et al. Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia. Exp. Hematol. 2014, 42(12). (1053-8 e1).
    • (2014) Exp. Hematol. , vol.42 , Issue.12
    • Salsbury, G.1    Cambridge, E.L.2    McIntyre, Z.3    Arends, M.J.4    Karp, N.A.5    Isherwood, C.6
  • 63
    • 0025351245 scopus 로고
    • + current. Differential sensitivity to block by class III antiarrhythmic agents
    • + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 1990, 96(1):195-215.
    • (1990) J. Gen. Physiol. , vol.96 , Issue.1 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 64
    • 33645317063 scopus 로고    scopus 로고
    • HERG potassium channels and cardiac arrhythmia
    • Sanguinetti M.C., Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 2006, 440(7083):463-469.
    • (2006) Nature , vol.440 , Issue.7083 , pp. 463-469
    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
  • 65
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • Sanguinetti M.C., Jiang C., Curran M.E., Keating M.T. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995, 81(2):299-307.
    • (1995) Cell , vol.81 , Issue.2 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 67
    • 23844435073 scopus 로고    scopus 로고
    • Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs
    • (discussion 66-70)
    • Sanguinetti M.C., Chen J., Fernandez D., Kamiya K., Mitcheson J., Sanchez-Chapula J.A. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs. Novartis Found. Symp. 2005, 266:159-166. (discussion 66-70).
    • (2005) Novartis Found. Symp. , vol.266 , pp. 159-166
    • Sanguinetti, M.C.1    Chen, J.2    Fernandez, D.3    Kamiya, K.4    Mitcheson, J.5    Sanchez-Chapula, J.A.6
  • 69
    • 0034642569 scopus 로고    scopus 로고
    • A constitutively open potassium channel formed by KCNQ1 and KCNE3
    • Schroeder B.C., Waldegger S., Fehr S., Bleich M., Warth R., Greger R., et al. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 2000, 403(6766):196-199.
    • (2000) Nature , vol.403 , Issue.6766 , pp. 196-199
    • Schroeder, B.C.1    Waldegger, S.2    Fehr, S.3    Bleich, M.4    Warth, R.5    Greger, R.6
  • 70
    • 80055008094 scopus 로고    scopus 로고
    • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
    • Soler Artigas M., Loth D.W., Wain L.V., Gharib S.A., Obeidat M., Tang W., et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat. Genet. 2011, 43(11):1082-1090.
    • (2011) Nat. Genet. , vol.43 , Issue.11 , pp. 1082-1090
    • Soler Artigas, M.1    Loth, D.W.2    Wain, L.V.3    Gharib, S.A.4    Obeidat, M.5    Tang, W.6
  • 71
    • 0016788039 scopus 로고
    • Myo-inositol transport in the central nervous system
    • Spector R., Lorenzo A.V. Myo-inositol transport in the central nervous system. Am. J. Physiol. 1975, 228(5):1510-1518.
    • (1975) Am. J. Physiol. , vol.228 , Issue.5 , pp. 1510-1518
    • Spector, R.1    Lorenzo, A.V.2
  • 73
    • 0023734276 scopus 로고
    • Cloning of a membrane protein that induces a slow voltage-gated potassium current
    • Takumi T., Ohkubo H., Nakanishi S. Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 1988, 242(4881):1042-1045.
    • (1988) Science , vol.242 , Issue.4881 , pp. 1042-1045
    • Takumi, T.1    Ohkubo, H.2    Nakanishi, S.3
  • 74
    • 0023893269 scopus 로고
    • Cloning of a probable potassium channel gene from mouse brain
    • Tempel B.L., Jan Y.N., Jan L.Y. Cloning of a probable potassium channel gene from mouse brain. Nature 1988, 332(6167):837-839.
    • (1988) Nature , vol.332 , Issue.6167 , pp. 837-839
    • Tempel, B.L.1    Jan, Y.N.2    Jan, L.Y.3
  • 76
    • 0034383396 scopus 로고    scopus 로고
    • KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
    • Tinel N., Diochot S., Borsotto M., Lazdunski M., Barhanin J. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 2000, 19(23):6326-6330.
    • (2000) EMBO J. , vol.19 , Issue.23 , pp. 6326-6330
    • Tinel, N.1    Diochot, S.2    Borsotto, M.3    Lazdunski, M.4    Barhanin, J.5
  • 78
    • 84879295718 scopus 로고
    • Jervell and Lange-Nielsen syndrome
    • (Seattle (WA)), R.A. Pagon, M.P. Adam, H.H. Ardinger, T.D. Bird, C.R. Dolan, C.T. Fong (Eds.)
    • Tranebjaerg L., Samson R.A., Green G.E. Jervell and Lange-Nielsen syndrome. GeneReviews(R) 1993, (Seattle (WA)). R.A. Pagon, M.P. Adam, H.H. Ardinger, T.D. Bird, C.R. Dolan, C.T. Fong (Eds.).
    • (1993) GeneReviews(R)
    • Tranebjaerg, L.1    Samson, R.A.2    Green, G.E.3
  • 79
    • 41449094145 scopus 로고    scopus 로고
    • Differential association between HERG and KCNE1 or KCNE2
    • Um S.Y., McDonald T.V. Differential association between HERG and KCNE1 or KCNE2. PLoS ONE 2007, 2(9):e933.
    • (2007) PLoS ONE , vol.2 , Issue.9 , pp. e933
    • Um, S.Y.1    McDonald, T.V.2
  • 80
    • 33744970273 scopus 로고    scopus 로고
    • Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase
    • Weng J., Cao Y., Moss N., Zhou M. Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J. Biol. Chem. 2006, 281(22):15194-15200.
    • (2006) J. Biol. Chem. , vol.281 , Issue.22 , pp. 15194-15200
    • Weng, J.1    Cao, Y.2    Moss, N.3    Zhou, M.4
  • 82
    • 84877327214 scopus 로고    scopus 로고
    • Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen syndrome
    • Winbo A., Sandstrom O., Palmqvist R., Rydberg A. Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen syndrome. Cardiol. Young 2013, 23(3):325-334.
    • (2013) Cardiol. Young , vol.23 , Issue.3 , pp. 325-334
    • Winbo, A.1    Sandstrom, O.2    Palmqvist, R.3    Rydberg, A.4
  • 84
    • 33845607258 scopus 로고    scopus 로고
    • KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells
    • Yanglin P., Lina Z., Zhiguo L., Na L., Haifeng J., Guoyun Z., et al. KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells. Cancer Lett. 2007, 246(1-2):129-138.
    • (2007) Cancer Lett. , vol.246 , Issue.1-2 , pp. 129-138
    • Yanglin, P.1    Lina, Z.2    Zhiguo, L.3    Na, L.4    Haifeng, J.5    Guoyun, Z.6
  • 85
    • 84864557388 scopus 로고    scopus 로고
    • Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits
    • Ying S.W., Kanda V.A., Hu Z., Purtell K., King E.C., Abbott G.W., et al. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS ONE 2012, 7(8):e42756.
    • (2012) PLoS ONE , vol.7 , Issue.8 , pp. e42756
    • Ying, S.W.1    Kanda, V.A.2    Hu, Z.3    Purtell, K.4    King, E.C.5    Abbott, G.W.6
  • 86
    • 0010244063 scopus 로고    scopus 로고
    • MinK-related peptide 1: a beta subunit for the HCN ion channel subunit family enhances expression and speeds activation
    • Yu H., Wu J., Potapova I., Wymore R.T., Holmes B., Zuckerman J., et al. MinK-related peptide 1: a beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ. Res. 2001, 88(12):E84-E87.
    • (2001) Circ. Res. , vol.88 , Issue.12 , pp. E84-E87
    • Yu, H.1    Wu, J.2    Potapova, I.3    Wymore, R.T.4    Holmes, B.5    Zuckerman, J.6
  • 87
    • 84878153021 scopus 로고    scopus 로고
    • Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels
    • Yu H., Lin Z., Mattmann M.E., Zou B., Terrenoire C., Zhang H., et al. Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(21):8732-8737.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.21 , pp. 8732-8737
    • Yu, H.1    Lin, Z.2    Mattmann, M.E.3    Zou, B.4    Terrenoire, C.5    Zhang, H.6
  • 88
    • 0035947747 scopus 로고    scopus 로고
    • MinK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?
    • Zhang M., Jiang M., Tseng G.N. minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?. Circ. Res. 2001, 88(10):1012-1019.
    • (2001) Circ. Res. , vol.88 , Issue.10 , pp. 1012-1019
    • Zhang, M.1    Jiang, M.2    Tseng, G.N.3
  • 89
    • 84863023479 scopus 로고    scopus 로고
    • KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner
    • Zhang M., Wang Y., Jiang M., Zankov D.P., Chowdhury S., Kasirajan V., et al. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am. J. Physiol. Heart Circ. Physiol. 2012, 302(4):H910-H922.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.302 , Issue.4 , pp. H910-H922
    • Zhang, M.1    Wang, Y.2    Jiang, M.3    Zankov, D.P.4    Chowdhury, S.5    Kasirajan, V.6


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