Hormonal regulation of cardiac KCNE2 gene expression

Molecular and Cellular Endocrinology

Volumn 292, Issue 1-2, 2008, Pages 50-62

  Kundu, Pallob ^a   Ciobotaru, Andrea ^a   Foroughi, Sina ^a   Toro, Ligia ^a   Stefani, Enrico ^a   Eghbali, Mansoureh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ERE; Estrogen; Estrogen receptor alpha; KCNE2; MiRP1; Promoter

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; FULVESTRANT; POTASSIUM CHANNEL KCNE2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; GENE EXPRESSION; HORMONAL REGULATION; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OVARIECTOMY; PREGNANCY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; UPREGULATION;

5' FLANKING REGION; ANIMALS; BASE SEQUENCE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; EXONS; FEMALE; GENE EXPRESSION REGULATION; HELA CELLS; HORMONES; HUMANS; INTRONS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MYOCARDIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; PREGNANCY; PROTEIN BINDING; RESPONSE ELEMENTS; RNA, MESSENGER; TRANSCRIPTION INITIATION SITE;

EID: 49349114517     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.06.003     Document Type: Article

References (66)

1. Abbott G.W., Sesti F., Splawski I., Buck M.E., Lehmann M.H., Timothy K.W., Keating M.T., and Goldstein S.A. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97 (1999) 175-187
2. Barkhem T., Haldosen L.A., Gustafsson J.A., and Nilsson S. Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context. Mol. Endocrinol. 16 (2002) 2571-2581
3. Bjornstrom L., and Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19 (2005) 833-842
4. Boyle M.B., Azhderian E.M., Maclusky N.J., Naftolin F., and Kaczmarek L.K. Xenopus oocytes injected with rat uterine RNA express very slowly activating potassium currents. Science 235 (1987) 1221-1224
5. Breathnach R., and Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50 (1981) 349-383
6. Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., et al. The transcriptional landscape of the mammalian genome. Science 309 (2005) 1559-1563
7. Davuluri R.V., Grosse I., and Zhang M.Q. Computational identification of promoters and first exons in the human genome. Nat. Genet. 29 (2001) 412-417
8. Deschenes I., and Tomaselli G.F. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 528 (2002) 183-188
9. Dong J., Tsai-Morris C.H., and Dufau M.L. A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J. Biol. Chem. 281 (2006) 18825-18836
10. Down T.A., and Hubbard T.J. Computational detection and location of transcription start sites in mammalian genomic DNA. Genome Res. 12 (2002) 458-461
11. Drici M.D., Burklow T.R., Haridasse V., Glazer R.I., and Woosley R.L. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation 94 (1996) 1471-1474
12. Eghbali M., Deva R., Alioua A., Minosyan T.Y., Ruan H., Wang Y., Toro L., and Stefani E. Molecular and functional signature of heart hypertrophy during pregnancy. Circ. Res. 96 (2005) 1208-1216
13. Felipe A., Knittle T.J., Doyle K.L., Snyders D.J., and Tamkun M.M. Differential expression of Isk mRNAs in mouse tissue during development and pregnancy. Am. J. Physiol. 267 (1994) C700-C705
14. Fleming J.G., Spencer T.E., Safe S.H., and Bazer F.W. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. Endocrinology 147 (2006) 899-911
15. SK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus. Proceedings of the National Academy of Sciences of the United States of America, 87 (1990) 2975-2979
16. Frazer K.A., Pachter L., Poliakov A., Rubin E.M., and Dubchak I. VISTA: computational tools for comparative genomics. Nucleic Acids Res. 32 (2004) W273-W279
17. Galante P.A., Sakabe N.J., Kirschbaum-Slager N., and de Souza S.J. Detection and evaluation of intron retention events in the human transcriptome. RNA 10 (2004) 757-765
18. Gowda R.M., Khan I.A., Mehta N.J., Vasavada B.C., and Sacchi T.J. Cardiac arrhythmias in pregnancy: clinical and therapeutic considerations. Int. J. Cardiol. 88 (2003) 129-133
19. Hall J.M., McDonnell D.P., and Korach K.S. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol. Endocrinol. 16 (2002) 469-486
20. Hatcher C.J., Diman N.Y., McDermott D.A., and Basson C.T. Transcription factor cascades in congenital heart malformation. Trends Mol. Med. 9 (2003) 512-515
21. Hille B. Ion Channels of Excitable Membranes. third ed. (2001), Sinauer
22. Ince T.A., and Scotto K.W. A conserved downstream element defines a new class of RNA polymerase II promoters. J. Biol. Chem. 270 (1995) 30249-30252
23. Jakacka M., Ito M., Weiss J., Chien P.Y., Gehm B.D., and Jameson J.L. Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway. J. Biol. Chem. 276 (2001) 13615-13621
24. Jiang M., Zhang M., Tang D.G., Clemo H.F., Liu J., Holwitt D., Kasirajan V., Pond A.L., Wettwer E., and Tseng G.N. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Circulation 109 (2004) 1783-1788
25. Kim J.K., Pedram A., Razandi M., and Levin E.R. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J. Biol. Chem. 281 (2006) 6760-6767
26. Klinge C.M. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 29 (2001) 2905-2919
27. Klinge C.M., Jernigan S.C., Smith S.L., Tyulmenkov V.V., and Kulakosky P.C. Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha. Mol. Cell Endocrinol. 174 (2001) 151-166
28. Knudsen S. Promoter2.0: for the recognition of PolII promoter sequences. Bioinformatics 15 (1999) 356-361
29. Kundu P., Alioua A., Stefani E., and Toro L. Regulation of mouse slo gene expression: multiple promoters, transcription start sites and genomic action of estrogen. J. Biol. Chem. 282 (2007) 27478-27492
30. Li T., Li Y.M., Jia Z.Q., Chen P., Ma K.T., and Zhou C.Y. Carboxyl terminus of Nkx2.5 impairs its interaction with p300. J. Mol. Biol. 370 (2007) 976-992
31. Lue N.F., and Kornberg R.D. A possible role for the yeast TATA-element-binding protein in DNA replication. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 8018-8022
32. Lundquist A.L., Turner C.L., Ballester L.Y., and George Jr. A.L. Expression and transcriptional control of human KCNE genes. Genomics 87 (2006) 119-128
33. Mansilla A., Lopez-Sanchez C., de la Rosa E.J., Garcia-Martinez V., Martinez-Salas E., de P.F., and Hernandez-Sanchez C. Developmental regulation of a proinsulin messenger RNA generated by intron retention. EMBO Rep. 6 (2005) 1182-1187
34. Maston G.A., Evans S.K., and Green M.R. Transcriptional Regulatory Elements in the Human Genome. Annu. Rev. Genomics Hum. Genet. 7 (2006) 29-59
35. McCrossan Z.A., and Abbott G.W. The MinK-related peptides. Neuropharmacology 47 (2004) 787-821
36. Moller C., and Netzer R. Effects of estradiol on cardiac ion channel currents. Eur. J. Pharmacol. 532 (2006) 44-49
37. Nilsson S., Makela S., Treuter E., Tujague M., Thomsen J., Andersson G., Enmark E., Pettersson K., Warner M., and Gustafsson J.A. Mechanisms of estrogen action. Physiol. Rev. 81 (2001) 1535-1565
38. O'Lone R., Frith M.C., Karlsson E.K., and Hansen U. Genomic targets of nuclear estrogen receptors. Mol. Endocrinol. 18 (2004) 1859-1875
39. O'Mahony F., Alzamora R., Betts V., LaPaix F., Carter D., Irnaten M., and Harvey B.J. Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts. J. Biol. Chem. 282 (2007) 24563-24573
40. Panaghie G., and Abbott G.W. The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr. Pharm. Des. 12 (2006) 2285-2302
41. Patten R.D., and Karas R.H. Estrogen replacement and cardiomyocyte protection. Trends Cardiovasc. Med. 16 (2006) 69-75
42. Patten R.D., Pourati I., Aronovitz M.J., Baur J., Celestin F., Chen X., Michael A., Haq S., Nuedling S., Grohe C., Force T., Mendelsohn M.E., and Karas R.H. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ. Res. 95 (2004) 692-699
43. Pedram A., Razandi M., Lubahn D., Liu J., Vannan M., and Levin E.R. Estrogen inhibits cardiac hypertrophy: role of estrogen receptor beta to inhibit calcineurin. Endocrinology 149 (2008) 3361-3369
44. Plageman Jr. T.F., and Yutzey K.E. T-box genes and heart development: putting the "T" in heart. Dev. Dyn. 232 (2005) 11-20
45. Pragnell M., Snay K.J., Trimmer J.S., Maclusky N.J., Naftolin F., Kaczmarek L.K., and Boyle M.B. Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron 4 (1990) 807-812
46. Ranki H.J., Budas G.R., Crawford R.M., Davies A.M., and Jovanovic A. 17Beta-estradiol regulates expression of K(ATP) channels in heart-derived H9c2 cells. J. Am. Coll. Cardiol. 40 (2002) 367-374
47. Ranki H.J., Budas G.R., Crawford R.M., and Jovanovic A. Gender-specific difference in cardiac ATP-sensitive K(+) channels. J. Am. Coll. Cardiol. 38 (2001) 906-915
48. Ranki H.J., Crawford R.M., Budas G.R., and Jovanovic A. Ageing is associated with a decrease in the number of sarcolemmal ATP-sensitive K+ channels in a gender-dependent manner. Mech. Ageing Dev. 123 (2002) 695-705
49. Roepke T.K., Kontogeorgis A., Xu X., Young J., Purtell K., Gutstein D., Lerner D.J., and Abbott G.W. The role of MiRP1 (KCNE2) in murine ventricular repolarization. Biophys. J. (2008) (1751-Platform)
50. Roepke T.A., Malyala A., Bosch M.A., Kelly M.J., and Ronnekleiv O.K. Estrogen regulation of genes important for K+ channel signaling in the arcuate nucleus. Endocrinology 148 (2007) 4937-4951
51. Roepke T.K., Anantharam A., Kirchhoff P., Busque S.M., Young J.B., Geibel J.P., Lerner D.J., and Abbott G.W. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J. Biol. Chem. 281 (2006) 23740-23747
52. Saito T., Ciobotaru A., Toro L., Stefani E., and Eghbali M. Gender and estrogen determines outward potassium current densities in mouse ventricular myocytes. Biophys. J. (2008) (2988-Pos)
53. Sakabe N.J., and de Souza S.J. Sequence features responsible for intron retention in human. BMC Genomics 8 (2007) p. 59
54. Sanchez R., Nguyen D., Rocha W., White J.H., and Mader S. Diversity in the mechanisms of gene regulation by estrogen receptors. Bioessays 24 (2002) 244-254
55. Sandelin A., Carninci P., Lenhard B., Ponjavic J., Hayashizaki Y., and Hume D.A. Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat. Rev. Genet. 8 (2007) 424-436
56. Schug J. Using TESS to predict transcription factor binding sites in DNA sequence. Current Protocols in Bioinformatics (2003), Wiley-Interscience pp. 1-16
57. Smale S.T., and Kadonaga J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72 (2003) 449-479
58. Song M., Helguera G., Eghbali M., Zhu N., Zarei M.M., Olcese R., Toro L., and Stefani E. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones. J. Biol. Chem. 276 (2001) 31883-31890
59. Song M., Zhu N., Olcese R., Barila B., Toro L., and Stefani E. Hormonal control of protein expression and mRNA levels of the MaxiK channel alpha subunit in myometrium. FEBS Lett. 460 (1999) 427-432
60. Suzuki Y., Taira H., Tsunoda T., Mizushima-Sugano J., Sese J., Hata H., Ota T., Isogai T., Tanaka T., Morishita S., Okubo K., Sakaki Y., Nakamura Y., Suyama A., and Sugano S. Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep. 2 (2001) 388-393
61. Takumi T., Ohkubo H., and Nakanishi S. Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 242 (1988) 1042-1045
62. Watanabe T., Inoue S., Hiroi H., Orimo A., Kawashima H., and Muramatsu M. Isolation of estrogen-responsive genes with a CpG island library. Mol. Cell Biol. 18 (1998) 442-449
63. Wong C.M., Tsang S.Y., Yao X., Chan F.L., and Huang Y. Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids 73 (2008) 272-279
64. Xin M., Davis C.A., Molkentin J.D., Lien C.L., Duncan S.A., Richardson J.A., and Olson E.N. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 11189-11194
65. Yanglin P., Lina Z., Zhiguo L., Na L., Haifeng J., Guoyun Z., Jie L., Jun W., Tao L., Li S., Taidong Q., Jianhong W., and Daiming F. KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells. Cancer Lett. 246 (2007) 129-138
66. Zhang M., Jiang M., and Tseng G.N. MinK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?. Circ. Res. 88 (2001) 1012-1019