Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 21, 2013, Pages 8732-8737

  Yu, Haibo ^a,b   Lin, Zhihong ^a,b,f   Mattmann, Margrith E ^c,d   Zou, Beiyan ^a,b   Terrenoire, Cecile ^e   Zhang, Hongkang ^a,b   Wu, Meng ^a,b,f   McManus, Owen B ^a,b   Kass, Robert S ^e   Lindsley, Craig W ^c,d   Hopkins, Corey R ^c,d   Li, Min ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e University of Iowa ^*  (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

Cardiac physiology; Drug; Long QT; Pharmacology

Indexed keywords

ML 277; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SENSITIVITY; HEART CELL CULTURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOICHIOMETRY;

CARDIAC PHYSIOLOGY; DRUG; LONG QT; PHARMACOLOGY;

ACTION POTENTIALS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HEK293 CELLS; HUMANS; ION TRANSPORT; KCNQ1 POTASSIUM CHANNEL; MUSCLE PROTEINS; MYOCYTES, CARDIAC; PIPERIDINES; POTASSIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN MULTIMERIZATION; THIAZOLES; TOSYL COMPOUNDS;

EID: 84878153021     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300684110     Document Type: Article

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