Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Archives of Toxicology

Volumn 89, Issue 7, 2015, Pages 1135-1148

  Louisse, Jochem ^a,b   Bosgra, Sieto ^b   Blaauboer, Bas J ^c   Rietjens, Ivonne M C M ^a   Verwei, Miriam ^b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

All trans retinoic acid; Developmental toxicity; In vitro in vivo extrapolation; Physiologically based kinetic modeling; Reverse dosimetry; Solid phase microextraction

Indexed keywords

RETINOIC ACID;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DEVELOPMENTAL TOXICITY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KINETICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; AGED; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; BIOTRANSFORMATION; CACO 2 CELL LINE; CELL DIFFERENTIATION; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECTS; EVALUATION STUDY; FEASIBILITY STUDY; INTESTINE ABSORPTION; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; TOXICITY TESTING; YOUNG ADULT;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOTRANSFORMATION; CACO-2 CELLS; CELL DIFFERENTIATION; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; FEASIBILITY STUDIES; FEMALE; HUMANS; INTESTINAL ABSORPTION; KINETICS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL; RATS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TOXICITY TESTS; TRETINOIN; YOUNG ADULT;

EID: 84930926808     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1289-4     Document Type: Article

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