Xenoestrogenicity in in vitro assays is not caused by displacement of endogenous estradiol from serum proteins

Toxicological Sciences

Volumn 82, Issue 1, 2004, Pages 154-163

  Heringa, Minnie B ^a   van der Burg, Bart ^b   van Eijkeren, Jan C H ^c   Hermens, Joop L M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b BIODETECTION SYSTEMS B V   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Charcoal assay; Displacement; Estrogen; Serum proteins

Indexed keywords

CHARCOAL; ESTRADIOL; LIGAND; PLASMA PROTEIN; SULFATE;

ADSORPTION; ARTICLE; BINDING ASSAY; BINDING COMPETITION; BIOASSAY; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; EXPOSURE; FEMALE; HORMONE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; MATHEMATICAL MODEL; MEASUREMENT; PREDICTION; PROTEIN BINDING; SOLID PHASE MICROEXTRACTION;

ADSORPTION; BINDING SITES; BLOOD PROTEINS; CELL LINE; CHARCOAL; CULTURE MEDIA; ESTRADIOL; ESTROGENS, NON-STEROIDAL; HUMANS; INDICATORS AND REAGENTS; MODELS, BIOLOGICAL; XENOBIOTICS;

EID: 8444244052     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh238     Document Type: Article

References (44)

1. Abe, T., Komatsu, M., Takeishi, M., and Tsunekane, T. (1976). The alpha-fetoprotein level in the sera of bovine fetuses and calves. Jpn. J. Vet. Sci. 38, 339-345.
2. Arnold, S. F., Robinson, M. K., Notides, A. C., Guillette, L. J., Jr., and McLachlan, J. A. (1996). A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ. Health Perspect. 104, 544-548.
3. August, G. P., Tkachuk, M., and Grumbach, M. M. (1969). Plasma testosterone-binding affinity and testosterone in umbilical cord plasma, late pregnancy, prepubertal children, and adults. J. Clin. Endocrinol. Metab. 29, 891-899.
4. Campbell, P. S., and Clark, J. H. (1984). Effects of chlorpromazine on the inhibition and artifactual elevation of [3H]estradiol binding to estrogen receptors in rat uterine cytosol. J. Steroid Biochem. 21, 475-476.
5. Charlier, C., Albert, A., Herman, P., Hamoir, E., Gaspard, U., Meurisse, M., and Plomteux, G. (2003). Breast cancer and serum organochlorine residues. Occup. Environ. Med. 60, 348-351.
6. Colborn, T., vom Saal, F. S., and Soto, A. M. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101, 378-84.
7. Crain, D. A., Noriega, N., Vonier, P. M., Arnold, S. F., McLachlan, J. A., and Guillette, L. J., Jr. (1998). Cellular bioavailability of natural hormones and environmental contaminants as a function of serum and cytosolic binding factors. Toxicol. Ind. Health 14, 261-73.
8. Danzo, B. J. (1997). Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ. Health Perspect. 105, 294-301.
9. Déchaud, H., Ravard, C., Claustrat, F., de la Perriere, A. B., and Pugeat, M. (1999). Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids 64, 328-34.
10. Dobrila, N.-L. (1996). Albumin Binding Proteins, Identification and Functional Characterization (thesis). Rijksuniversiteit Leiden, Leiden (the Netherlands).
11. Dunn, J. F., Nisula, B. C., and Rodbard, D. (1981). Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J. Clin. Endocrinol. Metab. 53, 58-68.
12. Englebienne, P. (1984). The serum steroid transport proteins: Biochemistry and clinical significance. In Molecular aspects of medicine (H. Baum, J. Gergely and B. L. Fanburg, eds.), Vol. 7. Pergamon Press, New York.
13. EORTC, B. c. c. g. (1973). Standards for the assessment of estrogen receptors in human breast cancer. Eur. J. Cancer 9, 379-381.
14. Fairclough, R. J., Hunter, J. T., and Welch, R. A. (1976). Preparturient changes in plasma concentrations of estrone, estradiol-17beta and estradiol-17alpha in the fetal calf: Effects of dexamethasone infusion. Steroids 28, 881-888.
15. 3H]estradiol. Anal. Chem. 74, 5993-5997.
16. Ikezuki, Y., Tsutsumi, O., Takai, Y., Kamei, Y., and Taketani, Y. (2002). Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum. Reprod. 17, 2839-2841.
17. Ishihara, A., Sawatsubashi, S., and Yamauchi, K. (2003). Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol. Cell. Endocrinol. 199, 105-117.
18. Jobling, S., and Sumpter, J. P. (1993). Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 27, 361-372.
19. Krstevska-Konstantinova, M., Charlier, C., Craen, M., Du Caju, M., Heinrichs, C., de Beaufort, C., Plomteux, G., and Bourguignon, J. P. (2001). Sexual precocity after immigration from developing countries to Belgium: Evidence of previous exposure to organochlorine pesticides. Hum. Reprod. 16, 1020-1026.
20. Kuiper, G. G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustafsson, J. A. (1997). Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863-870.
21. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139, 4252-4263.
22. Laidley, C. W., and Thomas, P. (1994). Partial characterization of a sex-steroid binding-protein in the spotted sea-trout (Cynoscion nebulosus). Biol. Reprod. 51, 982-992.
23. Lemmen, J. G., van den Brink, C. E., Legler, J., van der Saag, P. T., and van der Burg, B. (2002). Detection of oestrogenic activity of steroids present during mammalian gestation using oestrogen receptor alpha- and oestrogen receptor beta-specific in vitro assays. J. Endocrinol. 174, 435-446.
24. Meulenberg, E. P. (2002). A new test to identify endocrine disruptors using sex hormone-binding globulins from human serum. Eur. J. Lipid Sci. Technol. 104, 131-136.
25. Milligan, S. R., Khan, O., and Nash, M. (1998). Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma. Gen. Comp. Endocrinol. 112, 89-95.
26. Mol, H. G. J., Sunarto, S., and Steijger, O. M. (2000). Determination of endocrine disruptors in water after derivatization with N-methyl-N-(tert.-butyldimethyl-trifluoroacetamide) using gas chromatography with mass spectrometric detection. J. Chromatogr. A 879, 97-112.
27. Nagel, S. C., vom Saal, F. S., Thayer, K. A., Dhar, M. G., Boechler, M., and Welshons, W. V. (1997). Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ. Health Perspect. 105, 70-76.
28. Peck, E. J., Jr., and Clark, J. H. (1977). Effect of ionic strength on charcoal adsorption assays of receptor-estradiol complexes. Endocrinology 101, 1034-43.
29. Peterson, A. J., Hunter, J. T., Welch, R. A. S., and Fairclough, R. J. (1975). Oestrogens in bovine fetal and maternal plasma near term. J. Reprod Fertil. 43, 179-181.
30. Pettersson, K. S., Vanharanta, R. M., and Soderholm, J. R. (1985). Pitfalls in the dextran-coated charcoal assay of estrogen receptors in breast cancer tissue. J. Steroid Biochem. 22, 39-45.
31. Reed, M. J., Cheng, R. W., Beranek, P. A., Few, J. D., Franks, S., Ghilchik, M. W., and James, V. H. (1986). The regulation of the biologically available fractions of oestradiol and testosterone in plasma. J. Steroid Biochem. 24, 317-20.
32. Rosenthal, H. E., Ludwig, G. A., Pietrzak, E., and Sandberg, A. A. (1975). Binding of the sulfates of estradiol-17 beta to human serum albumin and plasma. J. Clin. Endocrinol. Metab. 41, 1144-54.
33. Saeki, T., Cristiano, A., Lynch, M. J., Brattain, M., Kim, N., Normanno, N., Kenney, N., Ciardiello, F., and Salomon, D. S. (1991). Regulation by estrogen through the 5′-flanking region of the transforming growth factor alpha gene. Mol. Endocrinol. 5, 1955-1963.
34. Siiteri, P. K., Murai, J. T., Hammond, G. L., Nisker, J. A., Raymoure, W. J., and Kuhn, R. W. (1982). The serum transport of steroid hormones. Recent Prog. Horm. Res. 38, 457-510.
35. Skovgaard Poulsen, H. (1981). Oestrogen receptor assay-limitation of the method. Eur. J. Cancer 17, 495-501.
36. Skovgaard Poulsen, H. (1982). Estrogen receptors in human breast cancer: comparative features of the hydroxylapatite- and dextran-coated charcoal assay. Eur. J. Cancer Clin. Oncol. 18, 1075-1079.
37. Södergard, R., Bäckström, T., Shanbhag, V., and Carstensen, H. (1982). Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. J. Steroid Biochem. 16, 801-810.
38. Soto, A. M., Sonnenschein, C., Chung, K. L., Fernandez, M. F., Olea, N., and Serrano, F. O. (1995). The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ. Health Perspect. 103(Suppl 7), 113-122.
39. Thorpe, S. M. (1987). Steroid receptors in breast cancer: Sources of interlaboratory variation in dextran-charcoal assays. Breast Cancer Res. Treat. 9, 175-189.
40. Tollefsen, K. E. (2002). Interaction of estrogen mimics, singly and in combination, with plasma sex steroid-binding proteins in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 56, 215-225.
41. Vaes, W. H. J., Urrestarazu Ramos, E., Verbaar, H. J. M., Seinen, W., and Hermens, J. L. M. (1996). Measurement of the free concentration using solid-phase microextraction: binding to protein. Anal. Chem. 68, 4463-4467.
42. Vesanen, M. (1993). Bovine uterine, cervical and ovarian cytosol estrogen and progesterone receptor concentrations in cystic ovarian disease. Acta Vet. Scand. 34, 35-43.
43. Vignon, F., Terqui, M., Westley, B., Derocq, D., and Rochefort, H. (1980). Effects of plasma estrogen sulfates in mammary cancer cells. Endocrinology 106, 1079-1086.
44. Villeneuve, D. L., Kurunthachalam, K., Priest, B. J., and Giesy, J. P. (2002). In vitro assessment of potential mechanism-specific effects of polybrominated diphenyl ethers. Environ. Toxicol. Chem. 21, 2431-2433.