Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site

Neurobiology of Disease

Volumn 82, Issue , 2015, Pages 332-341

  Le François, Brice ^a,b   Soo, Jeremy ^a,b   Millar, Anne M ^a,b   Daigle, Mireille ^a,b   Le Guisquet, Anne Marie ^c   Leman, Samuel ^c   Minier, Frédéric ^c   Belzung, Catherine ^c   Albert, Paul R ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

5 HT1A receptor; Antidepressant; DNA methylation; Epigenetics; Gene expression; Plasticity; Raphe; Serotonin; Sp4; UCMS

Indexed keywords

IMIPRAMINE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; SEROTONIN 1A RECEPTOR; TRANSCRIPTION FACTOR SP4; MESSENGER RNA; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHRONIC STRESS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DORSAL RAPHE NUCLEUS; GENE EXPRESSION; GROOMING; IMMUNOREACTIVITY; IN VIVO STUDY; INFRALIMBIC CORTEX; LIFE STRESS; LOCOMOTION; MAJOR DEPRESSION; MALE; MOUSE; NESTING; NONHUMAN; PATHOGENESIS; PREFRONTAL CORTEX; PRELIMBIC CORTEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEROTONINERGIC SYSTEM; TRANSCRIPTION INITIATION; ANIMAL; BAGG ALBINO MOUSE; CHRONIC DISEASE; CONSERVED SEQUENCE; DEPRESSIVE DISORDER; DISEASE MODEL; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; MENTAL STRESS; METABOLISM; PHYSIOLOGY; PROMOTER REGION;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CHRONIC DISEASE; CONSERVED SEQUENCE; CPG ISLANDS; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DNA METHYLATION; DORSAL RAPHE NUCLEUS; IMIPRAMINE; MALE; MICE, INBRED BALB C; PREFRONTAL CORTEX; PROMOTER REGIONS, GENETIC; RECEPTOR, SEROTONIN, 5-HT1A; RNA, MESSENGER; STRESS, PSYCHOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 84937888165     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.07.002     Document Type: Article

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