Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder

Journal of Psychiatric Research

Volumn 43, Issue 10, 2009, Pages 887-894

  Stockmeier, Craig A ^a,b   Howley, Eimear ^c   Shi, Xiaochun ^a   Sobanska, Anna ^d   Clarke, Gerard ^e   Friedman, Lee ^f   Rajkowska, Grazyna ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Public Hospital   (Poland)

^e UNIVERSITY COLLEGE CORK   (Ireland)

^f Functionalimageanalysiscom   (United States)

Author keywords

Depression; Orbitofrontal cortex; Postmortem; Serotonin 1A receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN H 3; 4 (2' METHOXY)PHENYL 1 [2' (N 2'' PYRIDAL) 4 FLUOROBENZAMIDO]ETHYL PIPERAZINE H 3; ALPRAZOLAM; AMANTADINE; AMITRIPTYLINE; ATENOLOL; CHLORPROMAZINE; CLOMIPRAMINE; CLONAZEPAM; DEXTROPROPOXYPHENE; DIAZEPAM; FLUOXETINE; HYDROCODONE; LEUPRORELIN; PAROXETINE; PSYCHOTROPIC AGENT; RADIOLIGAND; RISPERIDONE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SERTRALINE; TEMAZEPAM; TIOTIXENE; TRAZODONE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BRAIN TISSUE; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; MAJOR DEPRESSION; MALE; NEUROIMAGING; ORBITAL CORTEX; PATHOPHYSIOLOGY; PH; PRESCRIPTION; PRIORITY JOURNAL; PROTEIN BINDING; RADIOASSAY; SUICIDE;

ADULT; AGED; ANALYSIS OF VARIANCE; AUTORADIOGRAPHY; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; FRONTAL LOBE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; POSTMORTEM CHANGES; PROTEIN BINDING; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TRIGLYCERIDES; TRITIUM; YOUNG ADULT;

EID: 67349255009     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.01.001     Document Type: Article

References (50)

1. Aggleton J.P., Burton M.J., and Passingham R.E. Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta). Brain Research 190 (1980) 347-368
2. Amargos-Bosch M., Bortolozzi A., Puig M.V., Serrats J., Adell A., Celada P., et al. Co-expression and in vivo interaction of serotonin-1A and serotonin-2A receptors in pyramidal neurons of prefrontal cortex. Cerebral Cortex 14 (2004) 281-299
3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington DC: American Psychiatric Association; 1994.
4. Arango V., Underwood M.D., Gubbi A.V., and Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688 (1995) 121-133
5. Arranz B., Eriksson A., Mellerup E., Plenge P., and Marcusson J. Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims. Biological Psychiatry 35 (1994) 457-463
6. Aznar S., Qian Z., Shah R., Rahbek B., and Knudsen G.M. The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Research 959 (2003) 58-67
7. Aznavour N., Rbah L., Riad M., Reilhac A., Costes N., Descarries L., et al. A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment. Neuroimage 33 (2006) 834-842
8. Bhagwagar Z., Rabiner E.A., Sargent P.A., Grasby P.M., and Cowen P.J. Persistent reduction in brain serotonin-1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Molecular Psychiatry 9 (2004) 386-392
9. Blier P., and de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21 Suppl 2 (1999) 91S-98S
10. Burnet P.W., Eastwood S.L., and Harrison P.J. [3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochemistry International 30 (1997) 565-574
11. Carmichael S.T., and Price J.L. Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys. Journal of Comparative Neurology 363 (1995) 615-641
12. Chalmers D.T., Kwak S.P., Mansour A., Akil H., and Watson S.J. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. Journal of Neuroscience 13 (1993) 914-923
13. DeFelipe J., Arellano J.I., Gomez A., Azmitia E.C., and Munoz A. Pyramidal cell axons show a local specialization for GABA and 5-HT inputs in monkey and human cerebral cortex. Journal of Comparative Neurology 433 (2001) 148-155
14. Dillon K.A., Gross-Isseroff R., Israeli M., and Biegon A. Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: effects of age and alcohol. Brain Research 554 (1991) 56-64
15. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Greer P.J., and Mathis C. Serotonin type-1A receptor imaging in depression. Nuclear Medicine and Biology 27 (2000) 499-507
16. Drevets W.C. Neuroimaging studies of mood disorders. Biological Psychiatry 48 (2000) 813-829
17. Drevets W.C., Thase M.E., Moses-Kolko E.L., Price J., Frank E., Kupfer D.J., et al. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nuclear Medicine and Biology 34 (2007) 865-877
18. Gozlan H., Thibault S., Laporte A.M., Lima L., and Hamon M. The selective 5-HT1A antagonist radioligand [3H]WAY-100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes. European Journal of Pharmacology 288 (1995) 173-186
19. Hasler G., van der Veen J.W., Tumonis T., Meyers N., Shen J., and Drevets W.C. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Archive of General Psychiatry 64 (2007) 193-200
20. Kung H.F., Stevenson D.A., Zhuang Z.P., Kung M.P., Frederick D., and Hurt S.D. New 5-HT1A receptor antagonist: [3H]p-MPPF. Synapse 23 (1996) 344-346
21. Lanfumey L., and Hamon M. 5-HT1 receptors. Current Drug Targets of CNS Neurological Disorders 3 (2004) 1-10
22. Lemonde S., Turecki G., Bakish D., Du L., Hrdina P.D., Bown C.D., et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. Journal of Neuroscience 23 (2003) 8788-8799
23. Lopez-Figueroa A.L., Norton C.S., Lopez-Figueroa M.O., Armellini-Dodel D., Burke S., Akil H., et al. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological Psychiatry 55 (2004) 225-233
24. Lowther S., De Paermentier F., Cheetham S.C., Crompton M.R., Katona C.L., and Horton R.W. 5-HT1A receptor binding sites in postmortem brain samples from depressed suicides and controls. Journal of Affective Disorders 42 (1997) 199-207
25. Maciag D, Karolewicz B, O'Dwyer G, Srivastava K, Overholser J, Jurjus G, Dieter L, Herbst N, Stockmeier CA, Rajkowska G. Decreased level of glutamic acid decarboxylase 67 kDa in the prefrontal cortex in major depression. Program No. 707.1.2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience; 2007. Online.
26. Mann J.J. Role of the serotonergic system in the pathogenesis of major depression and suicide. Neuropsychopharmacology 21 (1999) 99S-105S
27. 1A binding sites in frontal cortex of suicide victims. Journal of Neural Transmission 85 (1991) 181-194
28. Mayberg H.S., Liotti M., Brannan S.K., McGinnis S., Mahurin R.K., Jerabek P.A., et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry 156 (1999) 675-682
29. Meltzer C.C., Price J.C., Mathis C.A., Butters M.A., Ziolko S.K., Moses-Kolko E., et al. Serotonin-1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 29 (2004) 2258-2265
30. Meyer J.H., McMain S., Kennedy S.H., Korman L., Brown G.M., DaSilva J.N., et al. Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. American Journal of Psychiatry 160 (2003) 90-99
31. Ou X.M., Storring J.M., Kushwaha N., and Albert P.R. Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene. Journal of Biological Chemistry 276 (2001) 14299-14307
32. Palego L., Marazziti D., Rotondo A., Batistini A., Lucacchini A., Naccarato A.G., et al. Further characterization of [3H]8-hydroxy-2-(di-n-propyl)aminotetralin binding sites in human brain postmortem. Neurochemistry International 30 (1997) 149-157
33. Parsey R.V., Oquendo M.A., Ogden R.T., Olvet D.M., Simpson N., Huang Y.Y., et al. Altered serotonin-1A binding in major depression: a [carbonyl-C-11]WAY-100635 positron emission tomography study. Biological Psychiatry 59 (2006) 106-113
34. Passchier J., van Waarde A., Pieterman R.M., Elsinga P.H., Pruim J., Hendrikse H.N., et al. In vivo delineation of 5-HT1A receptors in human brain with [18F]MPPF. Journal of Nuclear Medicine 41 (2000) 1830-1835
35. Pazos A, Probst A, Palacios JM. Serotonin receptors in the human brain--III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 1987;21:97-122.
36. Porrino L.J., Crane A.M., and Goldman-Rakic P.S. Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys. Journal of Comparative Neurology 198 (1981) 121-136
37. 18)F] MPPF positron emission tomography study. Biological Psychiatry 56 (2004) 587-591
38. Rajkowska G., Miguel-Hidalgo J.J., Wei J., Dilley G., Pittman S.D., Meltzer H.Y., et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry 45 (1999) 1085-1098
39. Rajkowska G., O'Dwyer G., Teleki Z., Stockmeier C.A., and Miguel-Hidalgo J.J. GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression. Neuropsychopharmacology 32 (2007) 471-482
40. Rempel-Clower N.L., and Barbas H. The laminar pattern of connections between prefrontal and anterior temporal cortices in the rhesus monkey is related to cortical structure and function. Cerebral Cortex 10 (2000) 851-865
41. Sanacora G., Mason G.F., Rothman D.L., and Krystal J.H. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. American Journal of Psychiatry 159 (2002) 663-665
42. Sanacora G., Gueorguieva R., Epperson C.N., Wu Y.T., Appel M., Rothman D.L., et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry 61 (2004) 705-713
43. Santana N., Bortolozzi A., Serrats J., Mengod G., and Artigas F. Expression of serotonin-1A and serotonin-2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex. Cerebral Cortex 14 (2004) 1100-1109
44. Sargent P.A., Kjaer K.H., Bench C.J., Rabiner E.A., Messa C., Meyer J., et al. Brain serotonin-1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Archives of General Psychiatry 57 (2000) 174-180
45. Spitzer RL, Endicott J. Schedule for affective disorders and schizophrenia (SADS). 3rd ed. New York: New York State Psychiatric Institute;1978.
46. Stockmeier C.A., Dilley G.E., Shapiro L.A., Overholser J.C., Thompson P.A., and Meltzer H.Y. Serotonin receptors in suicide victims with major depression. Neuropsychopharmacology 16 (1997) 162-173
47. Stockmeier C.A., Shapiro L.A., Dilley G.E., Kolli T.N., Friedman L., and Rajkowska G. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. Journal of Neuroscience 18 (1998) 7394-7401
48. Stockmeier C.A. Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of Psychiatry Research 37 (2003) 357-373
49. 1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. International Journal of Neuropsychopharmacology 2008;19:1-14 [Epub ahead of print].
50. Udo de Haes J.I., Harada N., Elsinga P.H., Maguire R.P., and Tsukada H. Effect of fenfluramine-induced increases in serotonin release on [18F]MPPF binding: a continuous infusion PET study in conscious monkeys. Synapse 59 (2006) 18-26