Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex

Neuroscience Letters

Volumn 469, Issue 3, 2010, Pages 380-384

  Kieran, Niamh ^a   Ou, Xiao Ming ^a   Iyo, Abiye H ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT1A; Freud 1; Major depression; NUDR; Serotonin; Social defeat

Indexed keywords

FIVE PRIME REPRESSOR ELEMENT UNDER DUAL REPRESSION PROTEIN 1; MESSENGER RNA; NUCLEAR DEFORMED EPIDERMAL AUTOREGULATORY FACTOR; PROTEIN DEAF 1; PROTEIN FREUD 1; PROTEIN NUDR; REGULATOR PROTEIN; SEROTONIN 1 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMOBILIZATION STRESS; MAJOR DEPRESSION; MENTAL STRESS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION;

ANIMALS; CHRONIC DISEASE; CORTICOSTERONE; DOMINANCE-SUBORDINATION; GENE EXPRESSION; MALE; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; REPRESSOR PROTEINS; RNA, MESSENGER; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 73649124534     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.12.032     Document Type: Article

References (57)

1. Abumaria N., Rygula R., Havemann-Reinecke U., Ruther E., Bodemer W., Roos C., and Flugge G. Identification of genes regulated by chronic social stress in the rat dorsal raphe nucleus. Cell. Mol. Neurobiol. 26 (2006) 145-162
2. Albert P.R., and Lemonde S. 5-HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist 10 (2004) 575-593
3. Arango V., Underwood M.D., Boldrini M., Tamir H., Kassir S.A., Hsiung S., Chen J.J., and Mann J.J. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25 (2001) 892-903
4. Aznar S., Qian Z., Shah R., Rahbek B., and Knudsen G.M. The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res. 959 (2003) 58-67
5. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
6. Bowen D.M., Najlerahim A., Procter A.W., Francis P.T., and Murphy E. Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 9504-9508
7. Czesak M., Lemonde S., Peterson E.A., Rogaeva A., and Albert P.R. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J. Neurosci. 26 (2006) 1864-1871
8. David S.P., Murthy N.V., Rabiner E.A., Munafo M.R., Johnstone E.C., Jacob R., Walton R.T., and Grasby P.M. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J. Neurosci. 25 (2005) 2586-2590
9. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Greer P.J., and Mathis C. Serotonin type-1A receptor imaging in depression. Nucl. Med. Biol. 27 (2000) 499-507
10. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Holt D., Greer P.J., Huang Y., Gautier C., and Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry 46 (1999) 1375-1387
11. Drevets W.C., Price J.L., Simpson Jr. J.R., Todd R.D., Reich T., Vannier M., and Raichle M.E. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386 (1997) 824-827
12. Flugge G., Kramer M., Rensing S., and Fuchs E. 5HT1A-receptors and behaviour under chronic stress: selective counteraction by testosterone. Eur. J. Neurosci. 10 (1998) 2685-2693
13. Froger N., Palazzo E., Boni C., Hanoun N., Saurini F., Joubert C., Dutriez-Casteloot I., Enache M., Maccari S., Barden N., Cohen-Salmon C., Hamon M., and Lanfumey L. Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress. J. Neurosci. 24 (2004) 2787-2796
14. Gartside S.E., Johnson D.A., Leitch M.M., Troakes C., and Ingram C.D. Early life adversity programs changes in central 5-HT neuronal function in adulthood. Eur. J. Neurosci. 17 (2003) 2401-2408
15. Gobbi G., Murphy D.L., Lesch K., and Blier P. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. J. Pharmacol. Exp. Ther. 296 (2001) 987-995
16. Gordon J.A., and Hen R. The serotonergic system and anxiety. Neuromolecular. Med. 5 (2004) 27-40
17. Hendricks T., Francis N., Fyodorov D., and Deneris E.S. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J. Neurosci. 19 (1999) 10348-10356
18. Holmes A., and Wellman C.L. Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neurosci. Biobehav. Rev. 33 (2009) 773-783
19. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
20. Iyo A.H., Kieran N., Chandran A., Albert P.R., Wicks I., Bissette G., and Austin M.C. Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress. Neuroscience 163 (2009) 1119-1127
21. Iyo A.H., Porter B., Deneris E.S., and Austin M.C. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse 57 (2005) 223-228
22. Jacobsen K.X., Vanderluit J.L., Slack R.S., and Albert P.R. HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression. Mol. Cell. Neurosci. 38 (2008) 349-358
23. Kinney G.G., Vogel G.W., and Feng P. Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. Brain Res. 756 (1997) 68-75
24. Kollack-Walker S., Don C., Watson S.J., and Akil H. Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat. J. Neuroendocrinol. 11 (1999) 547-559
25. Kollack-Walker S., Watson S.J., and Akil H. Social stress in hamsters: defeat activates specific neurocircuits within the brain. J. Neurosci. 17 (1997) 8842-8855
26. Lemonde S., Rogaeva A., and Albert P.R. Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. J. Neurochem. 88 (2004) 857-868
27. Lemonde S., Turecki G., Bakish D., Du L., Hrdina P.D., Bown C.D., Sequeira A., Kushwaha N., Morris S.J., Basak A., Ou X.M., and Albert P.R. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J. Neurosci. 23 (2003) 8788-8799
28. Lima F.B., Centeno M.L., Costa M.E., Reddy A.P., Cameron J.L., and Bethea C.L. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience 164 (2009) 676-691
29. Lopez J.F., Chalmers D.T., Little K.Y., Watson S.J., and Bennett A.E. Research award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry 43 (1998) 547-573
30. Mann J.J., Malone K.M., Diehl D.J., Perel J., Cooper T.B., and Mintun M.A. Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am. J. Psychiatry 153 (1996) 174-182
31. Maudhuit C., Hamon M., and Adrien J. Electrophysiological activity of raphe dorsalis serotoninergic neurones in a possible model of endogenous depression. Neuroreport 6 (1995) 681-684
32. Mayberg H.S., Liotti M., Brannan S.K., McGinnis S., Mahurin R.K., Jerabek P.A., Silva J.A., Tekell J.L., Martin C.C., Lancaster J.L., and Fox P.T. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156 (1999) 675-682
33. McEwen B.S. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 886 (2000) 172-189
34. McQuade R., and Young A.H. Future therapeutic targets in mood disorders: the glucocorticoid receptor. Br. J. Psychiatry 177 (2000) 390-395
35. Meltzer C.C., Price J.C., Mathis C.A., Butters M.A., Ziolko S.K., Moses-Kolko E., Mazumdar S., Mulsant B.H., Houck P.R., Lopresti B.J., Weissfeld L.A., and Reynolds C.F. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 29 (2004) 2258-2265
36. Miczek K.A. Tolerance to the analgesic, but not discriminative stimulus effects of morphine after brief social defeat in rats. Psychopharmacology (Berl) 104 (1991) 181-186
37. Mitchell P.J., and Redfern P.H. Animal models of depressive illness: the importance of chronic drug treatment. Curr. Pharm. Des. 11 (2005) 171-203
38. Moses-Kolko E.L., Wisner K.L., Price J.C., Berga S.L., Drevets W.C., Hanusa B.H., Loucks T.L., and Meltzer C.C. Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. Fertil. Steril. 89 (2008) 685-692
39. Nemeroff C.B. The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol. Psychiatry 1 (1996) 336-342
40. Neumaier J.F., Edwards E., and Plotsky P.M. 5-HT(1B) mRNA regulation in two animal models of altered stress reactivity. Biol. Psychiatry 51 (2002) 902-908
41. Ou X.M., Lemonde S., Jafar-Nejad H., Bown C.D., Goto A., Rogaeva A., and Albert P.R. Freud-1: a neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J. Neurosci. 23 (2003) 7415-7425
42. Papakostas G.I., Chuzi S.E., Sousa J.L., and Fava M. 5HT1A-mediated stimulation of cortisol release in major depression: use of non-invasive cortisol measurements to predict clinical response. Eur. Arch. Psychiatry Clin. Neurosci. (2009)
43. Pariante C.M., and Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49 (2001) 391-404
44. Parsey R.V., Arango V., Olvet D.M., Oquendo M.A., Van Heertum R.L., and John M.J. Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography. J. Cereb. Blood Flow Metab. 25 (2005) 785-793
45. Parsey R.V., Oquendo M.A., Ogden R.T., Olvet D.M., Simpson N., Huang Y.Y., Van Heertum R.L., Arango V., and Mann J.J. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol. Psychiatry 59 (2006) 106-113
46. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. (1998), Academic Press, Sydney
47. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., and Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 14476-14481
48. Rygula R., Abumaria N., Flugge G., Fuchs E., Ruther E., and Havemann-Reinecke U. Anhedonia and motivational deficits in rats: impact of chronic social stress. Behav. Brain Res. 162 (2005) 127-134
49. Rygula R., Abumaria N., Havemann-Reinecke U., Ruther E., Hiemke C., Zernig G., Fuchs E., and Flugge G. Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam. Behav. Pharmacol. 19 (2008) 183-196
50. Sargent P.A., Kjaer K.H., Bench C.J., Rabiner E.A., Messa C., Meyer J., Gunn R.N., Grasby P.M., and Cowen P.J. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57 (2000) 174-180
51. Shishkina G.T., Kalinina T.S., and Dygalo N.N. Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior. Ann. N.Y. Acad. Sci. 1148 (2008) 148-153
52. Stockmeier C.A. Neurobiology of serotonin in depression and suicide. Ann. N.Y. Acad. Sci. 836 (1997) 220-232
53. Stockmeier C.A., Shapiro L.A., Dilley G.E., Kolli T.N., Friedman L., and Rajkowska G. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J. Neurosci. 18 (1998) 7394-7401
54. Szewczyk B., Albert P.R., Burns A.M., Czesak M., Overholser J.C., Jurjus G.J., Meltzer H.Y., Konick L.C., Dieter L., Herbst N., May W., Rajkowska G., Stockmeier C.A., and Austin M.C. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int. J. Neuropsychopharmacol. 12 (2009) 155-168
55. Varnas K., Halldin C., and Hall H. Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum. Brain Mapp. 22 (2004) 246-260
56. von Frijtag J.C., Van den B.R., and Spruijt B.M. Imipramine restores the long-term impairment of appetitive behavior in socially stressed rats. Psychopharmacology (Berl) 162 (2002) 232-238
57. Ziabreva I., Poeggel G., Schnabel R., and Braun K. Separation-induced receptor changes in the hippocampus and amygdala of Octodon degus: influence of maternal vocalizations. J. Neurosci. 23 (2003) 5329-5336