A mitochondrial therapeutic reverses visual decline in mouse models of diabetes

DMM Disease Models and Mechanisms

Volumn 8, Issue 7, 2015, Pages 701-710

  Alam, Nazia M ^a,b   Iv, William C Mills ^a   Wong, Aimee A ^b   Douglas, Robert M ^c   Szeto, Hazel H ^a   Prusky, Glen T ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bendavia; Cardiolipin; Diabetic retinopathy; Hyperglycemia; Insulin resistance; Mouse; MTP 131; OKT; Optomotor; RPE; Spatial vision; SS 31

Indexed keywords

AGENTS ACTING ON THE EYE; CARDIOLIPIN; EYE DROPS; GLUCOSE; MTP 131; UNCLASSIFIED DRUG; ARGINYL-2,'6'-DIMETHYLTYROSYL-LYSYL-PHENYLALANINAMIDE; GLUCOSE BLOOD LEVEL; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; ELECTRON TRANSPORT; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VISION; VISUAL DISORDER; ANIMAL; C57BL MOUSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL DISEASES; MITOCHONDRION; PATHOPHYSIOLOGY; PERCEPTIVE THRESHOLD; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OLIGOPEPTIDES; OPHTHALMIC SOLUTIONS; SENSORY THRESHOLDS; VISION, OCULAR; VISUAL PERCEPTION;

EID: 84937871010     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.020248     Document Type: Article

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