Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: Evidence for retinal insulin resistance

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Fort, Patrice E ^a   Losiewicz, Mandy K ^a   Reiter, Chad E N ^b,c   Singh, Ravi S J ^b   Nakamura, Makoto ^b,d   Abcouwer, Steven F ^a   Barber, Alistair J ^b   Gardner, Thomas W ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; PHLORIZIN; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERGLYCEMIA; HYPOINSULINEMIA; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LOW DRUG DOSE; MALE; NONHUMAN; RAT; RETINA CELL; SIGNAL TRANSDUCTION; ANIMAL; CELL DEATH; DIABETIC RETINOPATHY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RETINA;

RATTUS;

ANIMALS; CELL DEATH; DIABETES MELLITUS; DIABETIC RETINOPATHY; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; PHLORHIZIN; RATS; RETINA; SIGNAL TRANSDUCTION;

EID: 80055062104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026498     Document Type: Article

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