Cardioprotective effect of Thymoquinone: A constituent of Nigella sativa L., against myocardial ischemia/reperfusion injury and ventricular arrhythmias in anaesthetized rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 28, Issue 4, 2015, Pages 1267-1273

  Gonca, Ersöz ^a   Kurt, Çaʇla ^a  

^a ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

Author keywords

Anaesthetized rats; Ischemia reperfusion injury; Thymoquinone; Ventricular arrhythmias

Indexed keywords

THYMOQUINONE; TRIPHENYLTETRAZOLIUM; BENZOQUINONE DERIVATIVE; CARDIOTONIC AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLACK CUMIN; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; INCIDENCE; LEFT CORONARY ARTERY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PREMEDICATION; QRS AMPLITUDE; RAT; REPERFUSION INJURY; ST SEGMENT ELEVATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; HEMODYNAMICS; MYOCARDIAL REPERFUSION INJURY; TACHYCARDIA, VENTRICULAR; WISTAR RAT;

ANIMALS; BENZOQUINONES; CARDIOTONIC AGENTS; HEMODYNAMICS; MALE; MYOCARDIAL REPERFUSION INJURY; NIGELLA SATIVA; RATS; RATS, WISTAR; TACHYCARDIA, VENTRICULAR;

EID: 84937863520     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Al-Ali A, Alkhawajah AA, Randhawa MA and Shaikh NA (2008). Oral and intraperitoneal LD 50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J. Ayub. Med. Coll., 20: 25-27.
2. Ali BH and Blunden G (2003). Pharmacological and toxicological properties of Nigella sativa. Phytother. Res., 17(4): 299-305.
3. Bozdogan O, Gonca E, Nebigil M and Tiryaki ES (2005). Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels. Int. Heart J., 46(4): 711-722.
4. Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, Pugsley MK, Ng GA, Roden DM, Camm AJ and Walker MJ (2013). The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacol. Ther., 139(2): 213-248.
5. Curtis MJ, Pugsley MK and Walker MJA (1993). Endogenous chemical mediators of ventricular arrhythmias in ischaemic heart disease. Cardiovasc. Res., 27(5): 703-719.
6. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC and Dreskin SC (2006). Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim. Biophys. Acta., 1760(7): 1088-1095.
7. Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M and Eckle T (2012). Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin. Cardiothorac. Vasc. Anesth., 16(3): 123-132.
8. Gonca E (2013). The effect of zileuton and montelukast on reperfusion-induced arrhythmias in anesthetized rats. Curr. Ther. Res. Clin. Exp., 75: 27-32.
9. Gonca E and Bozdogan O (2010). Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion induced arrhythmia in anesthetized male rats. J. Cardiovasc. Pharmacol. Ther., 15(4): 403-411.
10. Gökçe A, Oktar S, Koc A, Gonenci R, Yalcinkaya F, Yonden Z and Duru M (2010). Protective effect of Thymoquinone in experimental testicular torsion. Urol. Int., 85(4): 461-465.
11. Hausenloy DJ and Yellon DM (2013). Myocardial ischemia-reperfusion injury: A neglected therapeutic target. J. Clin. Invest., 123(1): 92-100.
12. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR and Ziaee T (2007). Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia reperfusion injury in rat hippocampus. Phytomedicine, 14(9): 621-627.
13. Hosseinzadeh H, Taiari S and Nassiri-Asl M (2012). Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle. Naunyn Schmiedebergs Arch. Pharmacol., 385(5): 503-508.
14. Lee YM, Chen HR, Hsiao G, Sheu JR, Wang JJ and Yen MH (2002). Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J. Pineal Res., 33(2): 72-80.
15. Lepran I, Koltai M, Siegmund W and Szekeres L (1983). Coronary artery ligation, early arrhythmias and determination of the ischemic area in conscious rats. J. Pharmacol. Methods, 9: 219-230.
16. Mansour MA, Nagi MN, El-Khatib AS and Al-Bekairi AM (2002). Effects of thymoquinone on antioxidant enzyme activities lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action. Cell. Biochem. Funct., 20(2): 143-151.
17. Marczin N, El-Habashi N, Hoare GS, Bundy RE and Yacoub M (2003). Antioxidants in myocardial ischemia-reperfusion injury: Therapeutic potential and basic mechanisms. Arch. Biochem. Biophys., 420(2): 222-236.
18. Moens AL, Claeys MJ, Timmermans JP and Vrints CJ (2005). Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int. J. Cardiol., 100: 179-190.
19. Nagi MN, Al-Shabanah OA, Hafez MM and Sayed-Ahmed MM (2011). Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J. Biochem. Mol. Toxicol., 25(3): 135-142.
20. Nagi MN and Mansour MA (2000). Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacol. Res., 41: 283-289.
21. Pasnik J and Zeman K (2009). Role of the neutrophil in myocardial ischemia-reperfusion injury. J. Organ Dysfunct., 5: 193-207.
22. Randhawa MA, Alghamdi MS and Maulik SK (2013). The effect of thymoquinone an active component of Nigella sativa, on isoproterenol induced myocardial injury. Pak. J. Pharm. Sci., 26(6): 1215-1219.
23. Rao PS, Cohen MV and Mueller HS (1983). Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J. Mol. Cell. Cardiol., 15: 713-716.
24. Sedlis SP (1992). Mechanisms of ventricular arrhythmias in acute ischemia and reperfusion. Cardiovasc. Clin., 22: 3-18.
25. Wang QD, Pernow J, Sjöquist PO and Ryden L (2002). Pharmacological possibilities for protection against myocardial reperfusion injury. Cardiovasc. Res., 55: 25-37.
26. Woo CC, Kumar AP, Sethi G and Tan KH (2012). Thymoquinone: Potential cure for inflammatory disorders and cancer. Biochem. Pharmacol., 83(4): 443-451.