Effect of thimerosal on arrhythmia induced by coronary ligation: The involvement of ATP-dependent potassium channels

International Heart Journal

Volumn 46, Issue 4, 2005, Pages 711-721

  Bozdoǧan, Ömer ^a   Gonca, Ersöz ^a   Nebigil, Melih ^a   Tiryaki, Eylem Suveren ^a  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

Author keywords

Arrhythmia; ATP dependent potassium channel blocker; Ischemia and reperfusion; Thimerosal

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIARRHYTHMIC AGENT; GLIBENCLAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; PINACIDIL; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; THIOMERSAL; GUANIDINE DERIVATIVE; N CYANO N' (1,1 DIMETHYLPROPYL) N'' (3 PYRIDINYL)GUANIDINE; N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-(3-PYRIDINYL)GUANIDINE; POTASSIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOSE RESPONSE; HEART ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HYDROPHILICITY; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX; RAT; REPERFUSION INJURY; SCORING SYSTEM; ST SEGMENT ELEVATION; VASCULAR ENDOTHELIUM; ANIMAL; BLOOD PRESSURE; CORONARY BLOOD VESSEL; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART MUSCLE REPERFUSION; HEART RATE; LIGATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ARRHYTHMIA; BLOOD PRESSURE; CORONARY VESSELS; ELECTROCARDIOGRAPHY; GUANIDINES; HEART RATE; LIGATION; MALE; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE II; PINACIDIL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; THIMEROSAL;

EID: 33644878472     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.46.711     Document Type: Article

References (36)

1. Hille B. G protein-coupled mechanisms and nervous signaling. Neuron 1992; 9: 187-95. (Review)
2. Ruppersberg JP, Frank R, Pongs O, Stocker M. Cloned neuronal IK(A) channels reopen during recovery from inactivation. Nature 1991; 353: 657-60.
3. Weik R, Neumcke B. ATP-sensitive potassium channels in adult mouse skeletal muscle: Characterization of the ATP-binding site. J Membr Biol 1989; 110: 217-26.
4. + channels of skeletal muscle fibers from young adult and aged rats: Possible involvement of thiol-dependent redox mechanisms in the age-related modifications of their biophysical and pharmacological properties. Mol Pharmacol 1994; 46: 754-61.
5. Coetzee WA, Nakamura TY, Faivre JF. Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells. Am J Physiol 1995; 269: H1625-33.
6. + channel in the pancreatic β cell. FEBS Letter 1993; 319: 128-32.
7. Lee K, Ozanne SE, Rowe IC, Hales CN, Ashford ML. The effects of trypsin on ATP-sensitive potassium channel properties and sulfonylurea receptors in the CRI-GI insulin-secreting cell line. Mol Pharmacol 1994; 46: 176-85.
8. + channel currents of pancreatic B-cells. Biochem Biophys Res Commun 1994; 200: 860-6.
9. Evans JR, Bielefeldt K. Regulation of sodium currents through oxidation and reduction of thiol residues. Neuroscience 2000; 101: 229-36.
10. 2+) channel of intermediate conductance in bovine aortic endothelial cells. J Membr Biol 1997; 158: 147-58.
11. Elferink JG. Thimerosal: A versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent. Gen Pharmacol 1999; 33: 1-6. (Review)
12. 2+ and membrane potential of thymocytes. Biochim Biophys Acta 1992; 1111: 65-74.
13. Gericke M, Droogmans G, Nilius B. Thimerosal induced changes of intracellular calcium in human endothelial cells. Cell Calcium 1993; 14: 201-7.
14. Beny JL. Thimerosal hyperpolarizes arterial smooth muscles in an endothelium-dependent manner. Eur J Pharmacol 1990; 185: 235-8.
15. Crack P, Cocks T. Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery. Br J Pharmacol 1992; 107: 566-72.
16. Rosenblum WI, Nishimura H, Ellis EF, Nelson GH. The endothelium-dependent effects of thimerosal on mouse pial arterioles in vivo: Evidence for control of microvascular events by EDRF as well as prostaglandins. J Cereb Blood Flow Metab 1992; 12: 703-6.
17. Forstermann U, Goppelt-Strube M, Frolich JC, Busse R. Thimerosal, an inhibitor of endothelial acyl-coenzyme A: Lysolecitin acyltransferase, stimulates the production of a nonprostanoid endothelium-derived vascular relaxing factor. Adv Prostaglandin, Thromboxane, and Leukotriene Research 1987; 17B: 1108-11.
18. Kim E, Kim JH, Kim HS, Ryu SH, Sub PG Thimerosal stimulates focal adhesion kinase and cytoskeletal changes by redox modulation. Biochim Biophys Acta 2002; 1593: 9-15.
19. Linde C, Loffler C, Kessler C. Quast U. Interaction between thiol-modifying agents and P1075, a K(ATP) channel opener, in rat isolated aorta. Naunyn Schmiedebergs Arch Pharmacol 1997; 356: 467-74.
20. Lepran I, Baczko I, Varro A, Papp JG. ATP-sensitive potassium channel modulators: Both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats. J Pharmacol Exp Ther 1996; 273: 1215-20.
21. El-Reyani NE, Bozdogan O, Baczko I, Lepran I. Papp JG. Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats. Eur J Pharmacol 1999; 365: 187-92.
22. Bozdogan O, Lepran I, Papp J Gy. Effect of combination of glibenclamide, an ATP-dependent potassium channel blocker, and metaprolol, a cardioselective β-adrenoreceptor blocker, during myocardial infarction in conscious rats. Turk J Med Sci 2000; 30: 517-22.
23. Bozdogan O, Gonca E, Suveren E, Gokce F. Mechanisms of glibenclamide-mediated anti-arrhythmia and ischemic conditioning in a rat model of myocardial infarction: Role of yohimbine treatment. Turk J Med Sci 2004; 34: 21-7.
24. Iskit AP, Gue MO. Thimerosal attenuates ischemia-reperfusion arrhythmias in rats: No modification by anti-ischemic agent trimetazidine or endothelin receptor antagonist bosentan. Pharmacol Res 1996; 34: 17-23.
25. Walker MJ, Curtis MJ, Hearse DJ, et al. The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res 1988; 22: 447-55.
26. Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 1991; 261: H1675-86.
27. Quast U. Potassium channel openers: Pharmacological and clinical aspects. Fundam Clin Pharmacol 1992; 6: 279-93. (Review)
28. + channel openers and 'natural' cardioprotection. Trends Pharmacol Sci 1992; 13: 269-72. (Review)
29. Edwards G, Weston AH. Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells. Br J Pharmacol 1993; 110: 1280-1.
30. Singh A, Lee KJ, Lee CY, Goldfarb RD, Tsan MF. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury. Circulation 1989; 80: 1795-804.
31. Grover GJ. Protective effects of ATP sensitive potassium channel openers in models of myocardial ischemia. Cardiovasc Res 1994; 8: 778-82.
32. Tosaki A, Szerdahely P, Engelman RM, Das DK. Potassium channel openers and blockers: Do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? J Pharmacol Exp Ther 1993; 267: 1355-62.
33. Matsuda T, Bates JN, Lewis SJ, Abboud FM, Chapleau MW. Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine. Circ Res 1995; 76: 426-33.
34. Chen CC, Lin YC, Chen SA, et al. Shortening of cardiac action potentials in endotoxic shock in guinea pigs is caused by an increase in nitric oxide activity and activation of the adenosine triphosphate-sensitive potassium channel. Crit Care Med 2000; 28: 1713-20.
35. + (ATP) channels, and cGMP in the preconditioning response of the rabbit. J Surg Res 2000; 92: 56-63.
36. Ockaili R, Emani VR, Okubo S, Brown M, Krottapalli K, Kukreja RC. Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: Role of nitric oxide. Am J Physiol 1999; 277: H2425-34.