WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

Science Signaling

Volumn 8, Issue 383, 2015, Pages

  Friedel, Perrine ^a,b,g   Kahle, Kristopher T ^c   Zhang, Jinwei ^d   Hertz, Nicholas ^e   Pisella, Lucie I ^a,b   Buhler, Emmanuelle ^a,b   Schaller, Fabienne ^a,b   Duan, Jingjing ^c   Khanna, Arjun R ^c   Bishop, Paul N ^f   Shokat, Kevan M ^e   Medina, Igor ^a,b  

^a Turing Center for Living Systems CENTURI Aix Marseille University   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE ION; POTASSIUM CHLORIDE COTRANSPORTER 2; PROTEIN KINASE WNK1; THREONINE; COTRANSPORTER; POTASSIUM-CHLORIDE SYMPORTERS; PRKWNK1 PROTEIN, MOUSE; PRKWNK1 PROTEIN, RAT; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; WNK1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; ENZYME ACTIVITY; GENE DELETION; GENE MUTATION; HOMEOSTASIS; HUMAN; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MEMBRANE DEPOLARIZATION; MOLECULAR BIOLOGY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SYNAPTIC INHIBITION; SYNAPTIC POTENTIAL; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; GENETICS; MEMBRANE POTENTIAL; METABOLISM; PC12 CELL LINE; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; EMBRYO, MAMMALIAN; GAMMA-AMINOBUTYRIC ACID; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIALS; MICE; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; SYMPORTERS;

EID: 84937821193     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaa0354     Document Type: Article

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