The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

Science Signaling

Volumn , Issue 334, 2014, Pages

  Alessi, Dario R ^a   Zhang, Jinwei ^a   Khanna, Arjun ^b   Hochdörfer, Thomas ^a   Shang, Yuze ^c   Kahle, Kristopher T ^b,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHLORIDE COTRANSPORTER; COTRANSPORTER; CULLIN; CULLIN 3; KELCH LIKE 3; PROTEIN KINASE; PROTEIN KINASE WNK; SPAK HOMOLOG OSR1; SPS1 RELATED PROLINE ALANINE RICH KINASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; PROTEIN KINASE OSR1; PROTEIN KINASE SPAK; SODIUM CHLORIDE COTRANSPORTER; MULTIPROTEIN COMPLEX; OSR1 KINASE, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; STK39 PROTEIN, HUMAN; WNK1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; AUTOPHOSPHORYLATION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CYTOPLASM; ELEVATED BLOOD PRESSURE; ENZYME ACTIVATION; ENZYME INHIBITION; ESSENTIAL HYPERTENSION; GABAERGIC SYSTEM; GAIN OF FUNCTION MUTATION; GENETIC ASSOCIATION; GITELMAN SYNDROME; HUMAN; LOSS OF FUNCTION MUTATION; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; ENZYME ACTIVITY; KIDNEY DISTAL TUBULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HOMEOSTASIS; KIDNEY; METABOLISM; NERVE CELL; OSMOLARITY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; NEURONS; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 84904397693     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005365     Document Type: Review

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