The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor

Pflugers Archiv European Journal of Physiology

Volumn 467, Issue 8, 2015, Pages 1783-1794

  Broadbent, Steven D ^a,c   Ramjeesingh, Mohabir ^b   Bear, Christine E ^b   Argent, Barry E ^a   Linsdell, Paul ^c   Gray, Michael A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

CFTR; Channel gating; Electrophysiology; Epithelial ion transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; CHLORIDE ION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN; CHLORIDE; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC FIELD; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN STABILITY; WHOLE CELL PATCH CLAMP; CHEMISTRY; ENZYME STABILITY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HYDROLYSIS; MEMBRANE POTENTIAL; METABOLISM; MOLECULAR MODEL; MUTATION; PATCH CLAMP TECHNIQUE; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; CHLORIDES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENZYME STABILITY; HEK293 CELLS; HUMANS; HYDROLYSIS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84937815812     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-014-1618-8     Document Type: Article

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