The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer

Biochemical Journal

Volumn 401, Issue 2, 2007, Pages 581-586

  Stratford, Fiona L L ^a   Ramjeesingh, Mohabir ^a   Cheung, Joanne C ^a   Huan, Ling Jun ^a   Bear, Christine E ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

2 (3) O (2,4,6 trinitrophenyl)adenosine 5 triphosphate (TNP ATP) affinity; Co immunoprecipitation; Cystic fibrosis transmembrane conductance regulator (CFTR); Nucleotide binding domain (NBD); Protein purification; Walker B motif

Indexed keywords

CATALYSIS; COMPLEXATION; DIMERS; HYDROLYSIS; INTERFACES (MATERIALS); STABILIZERS (AGENTS);

CO IMMUNOPRECIPITATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); NUCLEOTIDE BINDING DOMAIN (NBD); PROTEIN PURIFICATION; WALKER B MOTIF;

ENZYMES;

ADENOSINE TRIPHOSPHATASE; GLUTAMIC ACID; HETERODIMER; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HYDROLYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIMERIZATION; GLUTAMIC ACID; HUMANS; IMMUNOPRECIPITATION; NUCLEOTIDES;

EID: 33846521753     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060968     Document Type: Article

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