Interaction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel

Biochemistry and Cell Biology

Volumn 92, Issue 5, 2014, Pages 390-396

  Broadbent, Steven D ^a,b   Wang, Wuyang ^a,c   Linsdell, Paul ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

CFTR; Disulfide crosslinking; Electrophysiology; Extracellular loop; Substituted cysteine accessibility mutagenesis

Indexed keywords

CHEMICAL REACTIONS; CHLORINE COMPOUNDS; ELECTROPHYSIOLOGY;

CFTR; CHANNEL FUNCTIONS; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DISULFIDE CROSS-LINKING; EXTRACELLULAR LOOPS; RELATIVE MOVEMENT; RELATIVE ORIENTATION;

AMINO ACIDS;

CHLORIDE CHANNEL; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISULFIDE; REAGENT; CFTR PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DISULFIDE BOND; ELECTROPHYSIOLOGY; NONHUMAN; PATCH CLAMP TECHNIQUE; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HAMSTER; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CRICETINAE; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84911061873     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2014-0066     Document Type: Article

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