CFTR gating II: Effects of nucleotide binding on the stability of open states

Journal of General Physiology

Volumn 125, Issue 4, 2005, Pages 377-394

  Bompadre, Silvia G ^a,c   Cho, Jeong Han ^c   Wang, Xiaohui ^a,c   Zou, Xiaoqin ^b,c   Sohma, Yoshiro ^c,d   Li, Min ^c   Hwang, Tzyh Chang ^a,c  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

ABC transporter; Chloride channel; Energetics; Macroscopic relaxation; Single channel kinetics

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; NUCLEOTIDE; NUCLEOTIDE BINDING PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CHO CELL; CONFORMATIONAL TRANSITION; ENTHALPY; GENE MUTATION; HYDROLYSIS; ION CURRENT; ION TRANSPORT; KINETICS; NONHUMAN; PROTEIN DOMAIN; PROTEIN STABILITY;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; NUCLEOTIDES; PHOSPHORYLATION; PROTEIN BINDING;

EID: 17044401724     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200409228     Document Type: Article

References (32)

1. Ai, T., S.G. Bompadre, X. Wang, S. Hu, M. Li, and X-C. Hwang. 2004. Capsaicin potentiates wild-type and mutant CFTR chloride channel currents. Mol. Pharmacol. 65:1415-1426.
2. Aleksandrov, A.A., and J.R. Riordan. 1998. Regulation of CFTR ion channel gating by Mg-ATP. FEBS Lett. 431:97-101.
3. Aleksandrov, A.A., X.B. Chang, L. Aleksandrov, and J.R. Riordan. 2000. The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating. J Physiol. 528:259-265.
4. 2-terminal nucleotide binding domain and its role in channel gating. J. Gen. Physiol. 122:333-348.
5. Bompadre S.G., T. Ai, J.H. Cho, X. Wang, Y. Sohma, M. Li, and T.-C. Hwang. 2005. CFTR gating I: characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (AR-CFTR). J. Gen. Physiol. 125:361-375.
6. Carson, M.R., S.M. Travis, and M.J. Welsh. 1995. The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity. J. Biol. Chem. 270:1711-1717.
7. Chen, J., G. Lu, J. Lin, A.L. Davidson, and F.A. Quiocho. 2003. A tweezers-like motion of the ATP-binding cassette dimer in an ABC transports cycle. Mol. Cell. 12:651-661.
8. Cheng, S.H., R.J. Gregory, J. Marshall, S. Paul, D.W. Souza, G.A. White, C.R. O'Riordan, and A.E. Smith. 1990. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell. 63:827-834.
9. Csanady, L. 2000. Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms. Biophys. J. 78:785-799.
10. Diederichs, K.J. Diez, G. Greller, C. Muller,J. Breed, C. Schnell, C. Vonrhein, W. Boos, and W. Weite. 2000. Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19(22): 5951-5961.
11. Fetsch, E.E., and A.L. Davidson. 2003. Maltose transport through the inner membrane of E. coli. Front. Biosci. 8:d652-d660.
12. Gadsby, D.C., and A.C. Nairn. 1999. Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol. Rev. 79:S77-S107.
13. Gaudet, R., and D.C. Wiley. 2001. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 20:4964-4972.
14. Gunderson, K.L., and R.R. Kopito. 1995. Conformational states of CFTR associated with channel gating: the role of ATP binding and hydrolysis. Cell. 82:231-239.
15. Hopfner, K.P., A. Karcher, D.S. Shin, L. Craig, L.M. Arthur, J.P. Carney, and J.A. Tainer. 2000. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell. 101:789-800.
16. Hung, L.W., I.X. Wang, K. Nikaido, P.Q. Liu, G.F. Ames, and S.H. Kim. 1998. Crystal structure of the ATP-binding subunit of an ABC transporter. Nature. 396(6712):703-707.
17. Karpowich, N., O. Martsinkevich, L. Millen, Y.R. Yuan, P.L. Dai, K. MacVey, P.J. Thomas, and J.F. Hunt. 2001. Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter. Structure (Camb). 9:571-586.
18. Lewis, H.A., S.G. Buchanan, S.K. Burley, K. Conners, M. Dickey, M. Dorwart, R. Fowler, X. Gao, W.B. Guggino, W.A. Hendrickson, et al. 2004. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J. 23:282-293.
19. Locher, K.P., A.T. Lee, and D.C. Rees. 2002. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science. 296:1091-1098.
20. Moody, J.E., L. Millen, D. Binns, J.F. Hunt, and P.J. Thomas. 2002. Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters. J. Biol. Chem. 277:21111-21114.
21. Powe, A., L. Al-Nakkash, M. Li, and T-C. Hwang. 2002. Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide binding domains. J. Physiol 539:333-346.
22. Schmitt, L., H. Benabdelhak, M.A. Blight, I.B. Holland, and M.T. Stubbs. 2003. Crystal structure of the nucleotide-binding domain of the ABC-transporter haemolysin B: identification of a variable region within ABC helical domains. J. Mol. Biol. 330:333-342.
23. Smith, P.C., N. Karpowich, L. Millen, J.E. Moody, J. Rosen, P.J. Thomas, and J.F. Hunt. 2002. ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol. Cell. 10:139-149.
24. Szabo, K., G. Szakacs, T. Hegeds, and B. Sarkadi. 1999. Nucleotide occlusion in the human cystic fibrosis transmembrane conductance regulator. Different patterns in the two nucleotide binding domains. J. Biol. Chem. 274:12209-12212.
25. Tao, T., J. Xie, M.L. Drumm, J. Zhao, P.B. Davis, and J. Ma. 1996. Slow conversions among subconductance states of cystic fibrosis transmembrane conductance regulator chloride channel. Biophys. J. 70:743-753.
26. Verdon, G., S.V. Albers, B.W. Dijkstra, A.J. Driessen, and A.M. Thunnissen. 2003. Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus. nucleotide-free and nucleotide-bound conformations. J. Mol. Biol. 330:343-358.
27. - channels. J. Gen. Physiol. 121:17-36.
28. Vergani, P, S.W. Lockless, A.C. Nairn, and D.C. Gadsby. 2005. CFTR channel opening by ATP-driven tight dimerization of its nucleotide binding domains. Nature. 433:876-880.
29. Wang, F., S. Zeltwanger, I. Yang, A. Nairn, and T.-C. Hwang. 1998. Action of genistein on CFTR gating: evidence of two binding sites with opposite effects. J. Gen. Physiol. 111:477-490.
30. Yuan, Y.R., S. Blecker, O. Martsinkevich, L. Millen, P.J. Thomas, and J.F. Hunt. 2001. The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter. J. Biol. Chem. 276:32313-32321.
31. Zeltwanger, S., F. Wang, G.T. Wang, K.D. Gillis, and X-C. Hwang. 1999. Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating scheme. J. Gen. Physiol. 113:541-554.
32. Zhou, Z., S. Hu, and T.-C. Hwang. 2001. Voltage-dependent flickery block of an open cystic fibrosis transmembrane conductance regulator (CFTR) channel pore. J. Physiol. 532:435-448.