-
1
-
-
77955059069
-
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
-
A.K. Ajay, A.K. Upadhyay, S. Singh, M.V. Vijayakumar, R. Kumari, V. Pandey, R. Boppana, and M.K. Bhat Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression Mol. Cancer 9 2010 204
-
(2010)
Mol. Cancer
, vol.9
, pp. 204
-
-
Ajay, A.K.1
Upadhyay, A.K.2
Singh, S.3
Vijayakumar, M.V.4
Kumari, R.5
Pandey, V.6
Boppana, R.7
Bhat, M.K.8
-
2
-
-
41549124086
-
The BRET technology and its application to screening assays
-
J. Bacart, C. Corbel, R. Jockers, S. Bach, and C. Couturier The BRET technology and its application to screening assays Biotechnol. J. 3 2008 311 324
-
(2008)
Biotechnol. J.
, vol.3
, pp. 311-324
-
-
Bacart, J.1
Corbel, C.2
Jockers, R.3
Bach, S.4
Couturier, C.5
-
3
-
-
24744437350
-
Roscovitine targets, protein kinases and pyridoxal kinase
-
S. Bach, M. Knockaert, J. Reinhardt, O. Lozach, S. Schmitt, B. Baratte, M. Koken, S.P. Coburn, L. Tang, and T. Jiang Roscovitine targets, protein kinases and pyridoxal kinase J. Biol. Chem. 280 2005 31208 31219
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31208-31219
-
-
Bach, S.1
Knockaert, M.2
Reinhardt, J.3
Lozach, O.4
Schmitt, S.5
Baratte, B.6
Koken, M.7
Coburn, S.P.8
Tang, L.9
Jiang, T.10
-
4
-
-
33750587438
-
Molecular dynamics with coupling to an external bath
-
H.J.C. Berendsen, J.P.M. Postma, W.F. van Gunsteren, A. Di-Nola, and J.R. Haak Molecular dynamics with coupling to an external bath J. Chem. Phys. 81 1984 3684 3690
-
(1984)
J. Chem. Phys.
, vol.81
, pp. 3684-3690
-
-
Berendsen, H.J.C.1
Postma, J.P.M.2
Van Gunsteren, W.F.3
Di-Nola, A.4
Haak, J.R.5
-
6
-
-
0033782183
-
The relationship of tamoxifen with dementia, depression, and dependence in activities of daily living in elderly nursing home residents
-
B. Breuer, and R. Anderson The relationship of tamoxifen with dementia, depression, and dependence in activities of daily living in elderly nursing home residents Women Health 31 2000 71 85
-
(2000)
Women Health
, vol.31
, pp. 71-85
-
-
Breuer, B.1
Anderson, R.2
-
7
-
-
77953284982
-
Analysis of interaction between tamoxifen and ctDNA in vitro by multi-spectroscopic methods
-
C. Cai, X. Chen, and F. Ge Analysis of interaction between tamoxifen and ctDNA in vitro by multi-spectroscopic methods Spectrochim. Acta A Mol. Biomol. Spectrosc. 76 2010 202 206
-
(2010)
Spectrochim. Acta A Mol. Biomol. Spectrosc.
, vol.76
, pp. 202-206
-
-
Cai, C.1
Chen, X.2
Ge, F.3
-
9
-
-
84909606335
-
CDK5 activator protein p25 preferentially binds and activates GSK3beta
-
H.M. Chow, D. Guo, J.C. Zhou, G.Y. Zhang, H.F. Li, K. Herrup, and J. Zhang CDK5 activator protein p25 preferentially binds and activates GSK3beta Proc. Natl. Acad. Sci. USA 111 2014 E4887 E4895
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E4887-E4895
-
-
Chow, H.M.1
Guo, D.2
Zhou, J.C.3
Zhang, G.Y.4
Li, H.F.5
Herrup, K.6
Zhang, J.7
-
10
-
-
84875975993
-
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss
-
R.M. Cohen, K. Rezai-Zadeh, T.M. Weitz, A. Rentsendorj, D. Gate, I. Spivak, Y. Bholat, V. Vasilevko, C.G. Glabe, and J.J. Breunig A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss J. Neurosci. 33 2013 6245 6256
-
(2013)
J. Neurosci.
, vol.33
, pp. 6245-6256
-
-
Cohen, R.M.1
Rezai-Zadeh, K.2
Weitz, T.M.3
Rentsendorj, A.4
Gate, D.5
Spivak, I.6
Bholat, Y.7
Vasilevko, V.8
Glabe, C.G.9
Breunig, J.J.10
-
11
-
-
80755132216
-
Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5
-
E. Contreras-Vallejos, E. Utreras, and C. Gonzalez-Billault Going out of the brain: non-nervous system physiological and pathological functions of Cdk5 Cell. Signal. 24 2012 44 52
-
(2012)
Cell. Signal.
, vol.24
, pp. 44-52
-
-
Contreras-Vallejos, E.1
Utreras, E.2
Gonzalez-Billault, C.3
-
12
-
-
79959952716
-
First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors
-
C. Corbel, Q. Wang, H. Bousserouel, A. Hamdi, B. Zhang, O. Lozach, Y. Ferandin, V.B. Tan, F. Gueritte, and P. Colas First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors Biotechnol. J. 6 2011 860 870
-
(2011)
Biotechnol. J.
, vol.6
, pp. 860-870
-
-
Corbel, C.1
Wang, Q.2
Bousserouel, H.3
Hamdi, A.4
Zhang, B.5
Lozach, O.6
Ferandin, Y.7
Tan, V.B.8
Gueritte, F.9
Colas, P.10
-
13
-
-
0029011701
-
A second generation force field for the simulation of proteins,nucleic acids, and organic molecules
-
W.D. Cornell, P. Cieplak, C.I. Bayly, I.R. Gould, K.M. Merz, D.M. Ferguson, D.C. Spellmeyer, T. Fox, J.W. Caldwell, and P.A. Kollman A second generation force field for the simulation of proteins,nucleic acids, and organic molecules J. Am. Chem. Soc. 117 1995 5179 5197
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 5179-5197
-
-
Cornell, W.D.1
Cieplak, P.2
Bayly, C.I.3
Gould, I.R.4
Merz, K.M.5
Ferguson, D.M.6
Spellmeyer, D.C.7
Fox, T.8
Caldwell, J.W.9
Kollman, P.A.10
-
14
-
-
4444262625
-
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
-
J.C. Cruz, and L.H. Tsai Cdk5 deregulation in the pathogenesis of Alzheimer's disease Trends Mol. Med. 10 2004 452 458
-
(2004)
Trends Mol. Med.
, vol.10
, pp. 452-458
-
-
Cruz, J.C.1
Tsai, L.H.2
-
15
-
-
33846823909
-
Particle mesh Ewald: An N.log(N) method for Ewald sums in large systems
-
T. Darden, D. York, and L. Pedersen Particle mesh Ewald: an N.log(N) method for Ewald sums in large systems J. Chem. Phys. 98 1993 10089 10092
-
(1993)
J. Chem. Phys.
, vol.98
, pp. 10089-10092
-
-
Darden, T.1
York, D.2
Pedersen, L.3
-
16
-
-
6444219756
-
Multiple targeting by the antitumor drug tamoxifen: A structure-activity study
-
P. de Medina, G. Favre, and M. Poirot Multiple targeting by the antitumor drug tamoxifen: a structure-activity study Curr. Med. Chem. Anticancer Agents 4 2004 491 508
-
(2004)
Curr. Med. Chem. Anticancer Agents
, vol.4
, pp. 491-508
-
-
De Medina, P.1
Favre, G.2
Poirot, M.3
-
18
-
-
84898771737
-
Alzheimer's disease research and development: A call for a new research roadmap
-
H.H. Feldman, M. Haas, S. Gandy, D.D. Schoepp, A.J. Cross, R. Mayeux, R.A. Sperling, H. Fillit, D.L. van de Hoef, and S. Dougal Alzheimer's disease research and development: a call for a new research roadmap Ann. N Y Acad. Sci. 1313 2014 1 16
-
(2014)
Ann. N y Acad. Sci.
, vol.1313
, pp. 1-16
-
-
Feldman, H.H.1
Haas, M.2
Gandy, S.3
Schoepp, D.D.4
Cross, A.J.5
Mayeux, R.6
Sperling, R.A.7
Fillit, H.8
Van De Hoef, D.L.9
Dougal, S.10
-
19
-
-
77953149881
-
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
-
G. Feldmann, A. Mishra, S.M. Hong, S. Bisht, C.J. Strock, D.W. Ball, M. Goggins, A. Maitra, and B.D. Nelkin Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling Cancer Res. 70 2010 4460 4469
-
(2010)
Cancer Res.
, vol.70
, pp. 4460-4469
-
-
Feldmann, G.1
Mishra, A.2
Hong, S.M.3
Bisht, S.4
Strock, C.J.5
Ball, D.W.6
Goggins, M.7
Maitra, A.8
Nelkin, B.D.9
-
20
-
-
12144289984
-
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
-
R.A. Friesner, J.L. Banks, R.B. Murphy, T.A. Halgren, J.J. Klicic, D.T. Mainz, M.P. Repasky, E.H. Knoll, M. Shelley, and J.K. Perry Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy J. Med. Chem. 47 2004 1739 1749
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1739-1749
-
-
Friesner, R.A.1
Banks, J.L.2
Murphy, R.B.3
Halgren, T.A.4
Klicic, J.J.5
Mainz, D.T.6
Repasky, M.P.7
Knoll, E.H.8
Shelley, M.9
Perry, J.K.10
-
21
-
-
33845915536
-
Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5
-
S. Goodyear, and M.C. Sharma Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5 Exp. Mol. Pathol. 82 2007 25 32
-
(2007)
Exp. Mol. Pathol.
, vol.82
, pp. 25-32
-
-
Goodyear, S.1
Sharma, M.C.2
-
22
-
-
33847016153
-
Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography
-
D. Guiffant, D. Tribouillard, F. Gug, H. Galons, L. Meijer, M. Blondel, and S. Bach Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography Biotechnol. J. 2 2007 68 75
-
(2007)
Biotechnol. J.
, vol.2
, pp. 68-75
-
-
Guiffant, D.1
Tribouillard, D.2
Gug, F.3
Galons, H.4
Meijer, L.5
Blondel, M.6
Bach, S.7
-
23
-
-
84856511126
-
Yeast two-hybrid methods and their applications in drug discovery
-
A. Hamdi, and P. Colas Yeast two-hybrid methods and their applications in drug discovery Trends Pharmacol. Sci. 33 2012 109 118
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 109-118
-
-
Hamdi, A.1
Colas, P.2
-
24
-
-
0014053604
-
A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
-
M.J. Harper, and A.L. Walpole A new derivative of triphenylethylene: effect on implantation and mode of action in rats J. Reprod. Fertil. Suppl. 13 1967 101 119
-
(1967)
J. Reprod. Fertil. Suppl.
, vol.13
, pp. 101-119
-
-
Harper, M.J.1
Walpole, A.L.2
-
25
-
-
0037364074
-
Tamoxifen: A most unlikely pioneering medicine
-
V.C. Jordan Tamoxifen: a most unlikely pioneering medicine Nat. Rev. Drug Discov. 2 2003 205 213
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 205-213
-
-
Jordan, V.C.1
-
26
-
-
79952488353
-
Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors
-
J.K. Laha, X. Zhang, L. Qiao, M. Liu, S. Chatterjee, S. Robinson, K.S. Kosik, and G.D. Cuny Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors Bioorg. Med. Chem. Lett. 21 2011 2098 2101
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 2098-2101
-
-
Laha, J.K.1
Zhang, X.2
Qiao, L.3
Liu, M.4
Chatterjee, S.5
Robinson, S.6
Kosik, K.S.7
Cuny, G.D.8
-
27
-
-
7244260747
-
Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells
-
J.H. Lee, and K.T. Kim Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells J. Neurochem. 91 2004 634 647
-
(2004)
J. Neurochem.
, vol.91
, pp. 634-647
-
-
Lee, J.H.1
Kim, K.T.2
-
28
-
-
0034682414
-
Neurotoxicity induces cleavage of p35 to p25 by calpain
-
M.S. Lee, Y.T. Kwon, M. Li, J. Peng, R.M. Friedlander, and L.H. Tsai Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 2000 360 364
-
(2000)
Nature
, vol.405
, pp. 360-364
-
-
Lee, M.S.1
Kwon, Y.T.2
Li, M.3
Peng, J.4
Friedlander, R.M.5
Tsai, L.H.6
-
29
-
-
34447498931
-
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
-
J.H. Lee, H.S. Kim, S.J. Lee, and K.T. Kim Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death J. Cell. Sci. 120 2007 2259 2271
-
(2007)
J. Cell. Sci.
, vol.120
, pp. 2259-2271
-
-
Lee, J.H.1
Kim, H.S.2
Lee, S.J.3
Kim, K.T.4
-
30
-
-
0027087170
-
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2
-
J. Lew, R.J. Winkfein, H.K. Paudel, and J.H. Wang Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2 J. Biol. Chem. 267 1992 25922 25926
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25922-25926
-
-
Lew, J.1
Winkfein, R.J.2
Paudel, H.K.3
Wang, J.H.4
-
31
-
-
0037163879
-
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta
-
F. Liu, K. Iqbal, I. Grundke-Iqbal, and C.X. Gong Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta FEBS Lett. 530 2002 209 214
-
(2002)
FEBS Lett.
, vol.530
, pp. 209-214
-
-
Liu, F.1
Iqbal, K.2
Grundke-Iqbal, I.3
Gong, C.X.4
-
32
-
-
44949249877
-
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
-
R. Liu, B. Tian, M. Gearing, S. Hunter, K. Ye, and Z. Mao Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion Proc. Natl. Acad. Sci. USA 105 2008 7570 7575
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7570-7575
-
-
Liu, R.1
Tian, B.2
Gearing, M.3
Hunter, S.4
Ye, K.5
Mao, Z.6
-
34
-
-
0031037714
-
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
-
L. Meijer, A. Borgne, O. Mulner, J.P. Chong, J.J. Blow, N. Inagaki, M. Inagaki, J.G. Delcros, and J.P. Moulinoux Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5 Eur. J. Biochem. 243 1997 527 536
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 527-536
-
-
Meijer, L.1
Borgne, A.2
Mulner, O.3
Chong, J.P.4
Blow, J.J.5
Inagaki, N.6
Inagaki, M.7
Delcros, J.G.8
Moulinoux, J.P.9
-
35
-
-
0037448375
-
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
-
Y. Mettey, M. Gompel, V. Thomas, M. Garnier, M. Leost, I. Ceballos-Picot, M. Noble, J. Endicott, J.M. Vierfond, and L. Meijer Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects J. Med. Chem. 46 2003 222 236
-
(2003)
J. Med. Chem.
, vol.46
, pp. 222-236
-
-
Mettey, Y.1
Gompel, M.2
Thomas, V.3
Garnier, M.4
Leost, M.5
Ceballos-Picot, I.6
Noble, M.7
Endicott, J.8
Vierfond, J.M.9
Meijer, L.10
-
36
-
-
0029966469
-
The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
-
M. Nikolic, H. Dudek, Y.T. Kwon, Y.F. Ramos, and L.H. Tsai The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation Genes Dev. 10 1996 816 825
-
(1996)
Genes Dev.
, vol.10
, pp. 816-825
-
-
Nikolic, M.1
Dudek, H.2
Kwon, Y.T.3
Ramos, Y.F.4
Tsai, L.H.5
-
39
-
-
0023764676
-
Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue
-
C.A. O'Brian, G.M. Housey, and I.B. Weinstein Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue Cancer Res. 48 1988 3626 3629
-
(1988)
Cancer Res.
, vol.48
, pp. 3626-3629
-
-
O'Brian, C.A.1
Housey, G.M.2
Weinstein, I.B.3
-
40
-
-
0024241164
-
Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme
-
C.A. O'Brian, N.E. Ward, and B.W. Anderson Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme J. Natl. Cancer Inst. 80 1988 1628 1633
-
(1988)
J. Natl. Cancer Inst.
, vol.80
, pp. 1628-1633
-
-
O'Brian, C.A.1
Ward, N.E.2
Anderson, B.W.3
-
41
-
-
0029768093
-
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
-
T. Ohshima, J.M. Ward, C.G. Huh, G. Longenecker, Veeranna, H.C. Pant, R.O. Brady, L.J. Martin, and A.B. Kulkarni Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death Proc. Natl. Acad. Sci. USA 93 1996 11173 11178
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11173-11178
-
-
Ohshima, T.1
Ward, J.M.2
Huh, C.G.3
Longenecker, G.4
Veeranna5
Pant, H.C.6
Brady, R.O.7
Martin, L.J.8
Kulkarni, A.B.9
-
42
-
-
58149089468
-
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
-
S. Okada, E. Yamada, T. Saito, K. Ohshima, K. Hashimoto, M. Yamada, Y. Uehara, T. Tsuchiya, H. Shimizu, and K. Tatei CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation J. Biol. Chem. 283 2008 35455 35463
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35455-35463
-
-
Okada, S.1
Yamada, E.2
Saito, T.3
Ohshima, K.4
Hashimoto, K.5
Yamada, M.6
Uehara, Y.7
Tsuchiya, T.8
Shimizu, H.9
Tatei, K.10
-
43
-
-
3042751870
-
Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease
-
K. O'Neill, S. Chen, and R. Diaz Brinton Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease Exp. Neurol. 188 2004 268 278
-
(2004)
Exp. Neurol.
, vol.188
, pp. 268-278
-
-
O'Neill, K.1
Chen, S.2
Diaz Brinton, R.3
-
44
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
G.N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes, and L.H. Tsai Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
De La Monte, S.4
Dikkes, P.5
Tsai, L.H.6
-
45
-
-
77649250664
-
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro
-
D.W. Peterson, D.M. Ando, D.A. Taketa, H. Zhou, F.W. Dahlquist, and J. Lew No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro Proc. Natl. Acad. Sci. USA 107 2010 2884 2889
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 2884-2889
-
-
Peterson, D.W.1
Ando, D.M.2
Taketa, D.A.3
Zhou, H.4
Dahlquist, F.W.5
Lew, J.6
-
46
-
-
2442589341
-
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
-
P. Polychronopoulos, P. Magiatis, A.L. Skaltsounis, V. Myrianthopoulos, E. Mikros, A. Tarricone, A. Musacchio, S.M. Roe, L. Pearl, and M. Leost Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases J. Med. Chem. 47 2004 935 946
-
(2004)
J. Med. Chem.
, vol.47
, pp. 935-946
-
-
Polychronopoulos, P.1
Magiatis, P.2
Skaltsounis, A.L.3
Myrianthopoulos, V.4
Mikros, E.5
Tarricone, A.6
Musacchio, A.7
Roe, S.M.8
Pearl, L.9
Leost, M.10
-
47
-
-
2442495498
-
Development of novel targeted therapies in the treatment of malignant glioma
-
J.N. Rich, and D.D. Bigner Development of novel targeted therapies in the treatment of malignant glioma Nat. Rev. Drug Discov. 3 2004 430 446
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 430-446
-
-
Rich, J.N.1
Bigner, D.D.2
-
48
-
-
0038450245
-
Cdk5 regulates the organization of Nestin and its association with p35
-
C.M. Sahlgren, A. Mikhailov, S. Vaittinen, H.M. Pallari, H. Kalimo, H.C. Pant, and J.E. Eriksson Cdk5 regulates the organization of Nestin and its association with p35 Mol. Cell. Biol. 23 2003 5090 5106
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5090-5106
-
-
Sahlgren, C.M.1
Mikhailov, A.2
Vaittinen, S.3
Pallari, H.M.4
Kalimo, H.5
Pant, H.C.6
Eriksson, J.E.7
-
50
-
-
84871744906
-
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo
-
J.R. Sundaram, C.P. Poore, N.H. Sulaimee, T. Pareek, A.B. Asad, R. Rajkumar, W.F. Cheong, M.R. Wenk, G.S. Dawe, and K.H. Chuang Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo J. Neurosci. 33 2013 334 343
-
(2013)
J. Neurosci.
, vol.33
, pp. 334-343
-
-
Sundaram, J.R.1
Poore, C.P.2
Sulaimee, N.H.3
Pareek, T.4
Asad, A.B.5
Rajkumar, R.6
Cheong, W.F.7
Wenk, M.R.8
Dawe, G.S.9
Chuang, K.H.10
-
51
-
-
0034786018
-
Structure and regulation of the CDK5-p25(nck5a) complex
-
C. Tarricone, R. Dhavan, J. Peng, L.B. Areces, L.H. Tsai, and A. Musacchio Structure and regulation of the CDK5-p25(nck5a) complex Mol. Cell 8 2001 657 669
-
(2001)
Mol. Cell
, vol.8
, pp. 657-669
-
-
Tarricone, C.1
Dhavan, R.2
Peng, J.3
Areces, L.B.4
Tsai, L.H.5
Musacchio, A.6
-
52
-
-
0030731435
-
Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor
-
W. Zhang, R.E. Law, D.R. Hinton, and W.T. Couldwell Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor Cancer Lett. 120 1997 31 38
-
(1997)
Cancer Lett.
, vol.120
, pp. 31-38
-
-
Zhang, W.1
Law, R.E.2
Hinton, D.R.3
Couldwell, W.T.4
-
53
-
-
79960022984
-
An in silico approach for the discovery of CDK5/p25 interaction inhibitors
-
B. Zhang, C. Corbel, F. Gueritte, C. Couturier, S. Bach, and V.B. Tan An in silico approach for the discovery of CDK5/p25 interaction inhibitors Biotechnol. J. 6 2011 871 881
-
(2011)
Biotechnol. J.
, vol.6
, pp. 871-881
-
-
Zhang, B.1
Corbel, C.2
Gueritte, F.3
Couturier, C.4
Bach, S.5
Tan, V.B.6
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