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Volumn 759, Issue , 2015, Pages 272-277

Translational value of animal models of asthma: Challenges and promises

Author keywords

Exacerbation; House dust mite; Ovalbumin; Severe asthma; Viral infection

Indexed keywords

HOUSE DUST ALLERGEN; OVALBUMIN;

EID: 84937762632     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.037     Document Type: Review
Times cited : (50)

References (104)
  • 1
    • 0037108373 scopus 로고    scopus 로고
    • House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1
    • N. Asokananthan, P.T. Graham, D.J. Stewart, A.J. Bakker, K.A. Eidne, P.J. Thompson, and G.A. Stewart House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1 J. Immunol. 169 2002 4572 4578
    • (2002) J. Immunol. , vol.169 , pp. 4572-4578
    • Asokananthan, N.1    Graham, P.T.2    Stewart, D.J.3    Bakker, A.J.4    Eidne, K.A.5    Thompson, P.J.6    Stewart, G.A.7
  • 2
    • 0037323148 scopus 로고    scopus 로고
    • Effect of inhaled ultrafine carbon particles on the allergic airway response in ragweed-sensitized dogs
    • E.G. Barrett, K. Rudolph, L.E. Bowen, B.A. Muggenburg, and D.E. Bice Effect of inhaled ultrafine carbon particles on the allergic airway response in ragweed-sensitized dogs Inhal. Toxicol. 15 2003 151 165
    • (2003) Inhal. Toxicol. , vol.15 , pp. 151-165
    • Barrett, E.G.1    Rudolph, K.2    Bowen, L.E.3    Muggenburg, B.A.4    Bice, D.E.5
  • 5
    • 84885177716 scopus 로고    scopus 로고
    • Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma
    • R. Berair, and I.D. Pavord Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma Curr. Allergy Asthma Rep. 13 2013 469 476
    • (2013) Curr. Allergy Asthma Rep. , vol.13 , pp. 469-476
    • Berair, R.1    Pavord, I.D.2
  • 6
    • 78349297214 scopus 로고    scopus 로고
    • Do the current house dust mite-driven models really mimic allergic asthma?
    • M.A. Birrell, A.J. Van Oosterhout, and M.G. Belvisi Do the current house dust mite-driven models really mimic allergic asthma? Eur. Respir. J. 36 2010 1220 1221
    • (2010) Eur. Respir. J. , vol.36 , pp. 1220-1221
    • Birrell, M.A.1    Van Oosterhout, A.J.2    Belvisi, M.G.3
  • 7
    • 0037336914 scopus 로고    scopus 로고
    • Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite
    • R.J. Bischof, K. Snibson, R. Shaw, and E.N. Meeusen Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite Clin. Exp. Allergy: J. Br. Soc. Clin. Immunol. 33 2003 367 375
    • (2003) Clin. Exp. Allergy: J. Br. Soc. Clin. Immunol. , vol.33 , pp. 367-375
    • Bischof, R.J.1    Snibson, K.2    Shaw, R.3    Meeusen, E.N.4
  • 9
    • 84927598667 scopus 로고    scopus 로고
    • Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways
    • A. Brandelius, M. Andersson, and L. Uller Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways Respir. Med. 108 2014 1816 1819
    • (2014) Respir. Med. , vol.108 , pp. 1816-1819
    • Brandelius, A.1    Andersson, M.2    Uller, L.3
  • 10
    • 0029266795 scopus 로고
    • Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice
    • G. Brusselle, J. Kips, G. Joos, H. Bluethmann, and R. Pauwels Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice Am. J. Respir. Cell Mol. Biol. 12 1995 254 259
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.12 , pp. 254-259
    • Brusselle, G.1    Kips, J.2    Joos, G.3    Bluethmann, H.4    Pauwels, R.5
  • 11
    • 84876904833 scopus 로고    scopus 로고
    • Rhinovirus and dsRNA induce RIG-I-like receptors and expression of interferon beta and lambda1 in human bronchial smooth muscle cells
    • J. Calven, Y. Yudina, and L. Uller Rhinovirus and dsRNA induce RIG-I-like receptors and expression of interferon beta and lambda1 in human bronchial smooth muscle cells PloS One 8 2013 e62718
    • (2013) PloS One , vol.8
    • Calven, J.1    Yudina, Y.2    Uller, L.3
  • 12
    • 0037080361 scopus 로고    scopus 로고
    • Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene
    • S.P. Chapoval, K. Iijima, E.V. Marietta, M.K. Smart, A.I. Chapoval, A.G. Andrews, and C.S. David Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene J. Immunol. 168 2002 890 899
    • (2002) J. Immunol. , vol.168 , pp. 890-899
    • Chapoval, S.P.1    Iijima, K.2    Marietta, E.V.3    Smart, M.K.4    Chapoval, A.I.5    Andrews, A.G.6    David, C.S.7
  • 13
    • 84901848274 scopus 로고    scopus 로고
    • Defining phenotypes in asthma: a step towards personalized medicine
    • K.F. Chung Defining phenotypes in asthma: a step towards personalized medicine Drugs 74 2014 719 728
    • (2014) Drugs , vol.74 , pp. 719-728
    • Chung, K.F.1
  • 15
    • 0030689729 scopus 로고    scopus 로고
    • Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production
    • L. Cohn, R.J. Homer, A. Marinov, J. Rankin, and K. Bottomly Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production J. Exp. Med. 186 1997 1737 1747
    • (1997) J. Exp. Med. , vol.186 , pp. 1737-1747
    • Cohn, L.1    Homer, R.J.2    Marinov, A.3    Rankin, J.4    Bottomly, K.5
  • 18
    • 84924456862 scopus 로고    scopus 로고
    • Eosinophils and the ovalbumin mouse model of asthma
    • F. Daubeuf, and N. Frossard Eosinophils and the ovalbumin mouse model of asthma Methods Mol. Biol. 1178 2014 283 293
    • (2014) Methods Mol. Biol. , vol.1178 , pp. 283-293
    • Daubeuf, F.1    Frossard, N.2
  • 19
    • 84919688284 scopus 로고    scopus 로고
    • Endosymbiotic bacteria living inside the poultry red mite (Dermanyssus gallinae)
    • C.J. De Luna, C.V. Moro, J.H. Guy, L. Zenner, and O.A. Sparagano Endosymbiotic bacteria living inside the poultry red mite (Dermanyssus gallinae) Exp. Appl. Acarol. 48 2009 105 113
    • (2009) Exp. Appl. Acarol. , vol.48 , pp. 105-113
    • De Luna, C.J.1    Moro, C.V.2    Guy, J.H.3    Zenner, L.4    Sparagano, O.A.5
  • 20
    • 67650280751 scopus 로고    scopus 로고
    • Concurrent dual allergen exposure and its effects on airway hyperresponsiveness, inflammation and remodeling in mice
    • F.A. DiGiovanni, R. Ellis, J. Wattie, J.A. Hirota, D.S. Southam, and M.D. Inman Concurrent dual allergen exposure and its effects on airway hyperresponsiveness, inflammation and remodeling in mice Dis. Models Mech. 2 2009 275 282
    • (2009) Dis. Models Mech. , vol.2 , pp. 275-282
    • Digiovanni, F.A.1    Ellis, R.2    Wattie, J.3    Hirota, J.A.4    Southam, D.S.5    Inman, M.D.6
  • 22
    • 1042286444 scopus 로고    scopus 로고
    • Do mouse models of allergic asthma mimic clinical disease?
    • M.M. Epstein Do mouse models of allergic asthma mimic clinical disease? Int. Arch. Allergy Immunol. 133 2004 84 100
    • (2004) Int. Arch. Allergy Immunol. , vol.133 , pp. 84-100
    • Epstein, M.M.1
  • 24
    • 77949330370 scopus 로고    scopus 로고
    • The immunobiology of aluminium adjuvants: how do they really work?
    • C. Exley, P. Siesjo, and H. Eriksson The immunobiology of aluminium adjuvants: how do they really work? Trends Immunol. 31 2010 103 109
    • (2010) Trends Immunol. , vol.31 , pp. 103-109
    • Exley, C.1    Siesjo, P.2    Eriksson, H.3
  • 25
    • 84868925914 scopus 로고    scopus 로고
    • Guidelines for the Diagnosis and Management of Asthma - Summary Report 2007
    • Expert Panel Report3(EPR-3) Guidelines for the Diagnosis and Management of Asthma - Summary Report 2007 J. Allergy Clin. Immunol. 121 2008 1330
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1330
  • 28
    • 47749102523 scopus 로고    scopus 로고
    • Improved mouse models of allergy and allergic asthma - Chances beyond ovalbumin
    • B. Fuchs, and A. Braun Improved mouse models of allergy and allergic asthma - chances beyond ovalbumin Curr. Drug Targets 9 2008 495 502
    • (2008) Curr. Drug Targets , vol.9 , pp. 495-502
    • Fuchs, B.1    Braun, A.2
  • 29
  • 31
    • 80051930931 scopus 로고    scopus 로고
    • Orchestrating house dust mite-associated allergy in the lung
    • L.G. Gregory, and C.M. Lloyd Orchestrating house dust mite-associated allergy in the lung Trends Immunol. 32 2011 402 411
    • (2011) Trends Immunol. , vol.32 , pp. 402-411
    • Gregory, L.G.1    Lloyd, C.M.2
  • 32
    • 77951629448 scopus 로고    scopus 로고
    • Role of infection in the development and exacerbation of asthma
    • T.W. Guilbert, and L.C. Denlinger Role of infection in the development and exacerbation of asthma Expert Rev. Respir. Med. 4 2010 71 83
    • (2010) Expert Rev. Respir. Med. , vol.4 , pp. 71-83
    • Guilbert, T.W.1    Denlinger, L.C.2
  • 33
    • 0033208621 scopus 로고    scopus 로고
    • Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes
    • E. Hamelmann, K. Takeda, J. Schwarze, A.T. Vella, C.G. Irvin, and E.W. Gelfand Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes Am. J. Respir. Cell Mol. Biol. 21 1999 480 489
    • (1999) Am. J. Respir. Cell Mol. Biol. , vol.21 , pp. 480-489
    • Hamelmann, E.1    Takeda, K.2    Schwarze, J.3    Vella, A.T.4    Irvin, C.G.5    Gelfand, E.W.6
  • 34
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • H. Hammad, M. Chieppa, F. Perros, M.A. Willart, R.N. Germain, and B.N. Lambrecht House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells Nat. Med. 15 2009 410 416
    • (2009) Nat. Med. , vol.15 , pp. 410-416
    • Hammad, H.1    Chieppa, M.2    Perros, F.3    Willart, M.A.4    Germain, R.N.5    Lambrecht, B.N.6
  • 38
    • 84860655039 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in asthma
    • S.T. Holgate Innate and adaptive immune responses in asthma Nat. Med. 18 2012 673 683
    • (2012) Nat. Med. , vol.18 , pp. 673-683
    • Holgate, S.T.1
  • 39
    • 80051670719 scopus 로고    scopus 로고
    • Animal models of asthma: value, limitations and opportunities for alternative approaches
    • A.M. Holmes, R. Solari, and S.T. Holgate Animal models of asthma: value, limitations and opportunities for alternative approaches Drug Discov. Today 16 2011 659 670
    • (2011) Drug Discov. Today , vol.16 , pp. 659-670
    • Holmes, A.M.1    Solari, R.2    Holgate, S.T.3
  • 40
    • 78650669633 scopus 로고    scopus 로고
    • The role of the house dust mite-induced innate immunity in development of allergic response
    • A. Jacquet The role of the house dust mite-induced innate immunity in development of allergic response Int. Arch. Allergy Immunol. 155 2011 95 105
    • (2011) Int. Arch. Allergy Immunol. , vol.155 , pp. 95-105
    • Jacquet, A.1
  • 43
    • 1042277966 scopus 로고    scopus 로고
    • Repeated aerosol allergen exposure suppresses inflammation in B-cell-deficient mice with established allergic asthma
    • P. Jungsuwadee, M. Benkovszky, G. Dekan, G. Stingl, and M.M. Epstein Repeated aerosol allergen exposure suppresses inflammation in B-cell-deficient mice with established allergic asthma Int. Arch. Allergy Immunol. 133 2004 40 48
    • (2004) Int. Arch. Allergy Immunol. , vol.133 , pp. 40-48
    • Jungsuwadee, P.1    Benkovszky, M.2    Dekan, G.3    Stingl, G.4    Epstein, M.M.5
  • 44
    • 0028278872 scopus 로고
    • Animal models of occupational asthma
    • M.H. Karol Animal models of occupational asthma Eur. Respir. J. 7 1994 555 568
    • (1994) Eur. Respir. J. , vol.7 , pp. 555-568
    • Karol, M.H.1
  • 46
    • 0032193198 scopus 로고    scopus 로고
    • Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium
    • C. King, S. Brennan, P.J. Thompson, and G.A. Stewart Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium J. Immunol. 161 1998 3645 3651
    • (1998) J. Immunol. , vol.161 , pp. 3645-3651
    • King, C.1    Brennan, S.2    Thompson, P.J.3    Stewart, G.A.4
  • 47
    • 33750318921 scopus 로고    scopus 로고
    • Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite
    • E. Koumoundouros, R.J. Bischof, E.N. Meeusen, I.M. Mareels, and K.J. Snibson Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite Exp. Lung Res. 32 2006 321 330
    • (2006) Exp. Lung Res. , vol.32 , pp. 321-330
    • Koumoundouros, E.1    Bischof, R.J.2    Meeusen, E.N.3    Mareels, I.M.4    Snibson, K.J.5
  • 48
    • 84866465887 scopus 로고    scopus 로고
    • Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
    • R.K. Kumar, and P.S. Foster Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness? Front. Physiol. 3 2012 312
    • (2012) Front. Physiol. , vol.3 , pp. 312
    • Kumar, R.K.1    Foster, P.S.2
  • 49
    • 47749116885 scopus 로고    scopus 로고
    • The "classical" ovalbumin challenge model of asthma in mice
    • R.K. Kumar, C. Herbert, and P.S. Foster The "classical" ovalbumin challenge model of asthma in mice Curr. Drug Targets 9 2008 485 494
    • (2008) Curr. Drug Targets , vol.9 , pp. 485-494
    • Kumar, R.K.1    Herbert, C.2    Foster, P.S.3
  • 54
    • 34249025784 scopus 로고    scopus 로고
    • Building better mouse models of asthma
    • C.M. Lloyd Building better mouse models of asthma Curr. Allergy Asthma Rep. 7 2007 231 236
    • (2007) Curr. Allergy Asthma Rep. , vol.7 , pp. 231-236
    • Lloyd, C.M.1
  • 55
    • 84894267969 scopus 로고    scopus 로고
    • Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma
    • I. Mahmutovic-Persson, H. Akbarshahi, N.W. Bartlett, N. Glanville, S.L. Johnston, A. Brandelius, and L. Uller Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma Allergy 69 2014 348 358
    • (2014) Allergy , vol.69 , pp. 348-358
    • Mahmutovic-Persson, I.1    Akbarshahi, H.2    Bartlett, N.W.3    Glanville, N.4    Johnston, S.L.5    Brandelius, A.6    Uller, L.7
  • 57
    • 84904513365 scopus 로고    scopus 로고
    • Aligning mouse models of asthma to human endotypes of disease
    • R.A. Martin, S.R. Hodgkins, A.E. Dixon, and M.E. Poynter Aligning mouse models of asthma to human endotypes of disease Respirology 19 2014 823 833
    • (2014) Respirology , vol.19 , pp. 823-833
    • Martin, R.A.1    Hodgkins, S.R.2    Dixon, A.E.3    Poynter, M.E.4
  • 58
    • 0014417112 scopus 로고
    • Mites and house-dust allergy in bronchial asthma
    • K. Maunsell, D.G. Wraith, and A.M. Cunnington Mites and house-dust allergy in bronchial asthma Lancet 1 1968 1267 1270
    • (1968) Lancet , vol.1 , pp. 1267-1270
    • Maunsell, K.1    Wraith, D.G.2    Cunnington, A.M.3
  • 61
    • 84883782954 scopus 로고    scopus 로고
    • Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced asthma mouse model: consequences for steroid sensitivity
    • H. Mori, N.S. Parker, D. Rodrigues, K. Hulland, D. Chappell, J.S. Hincks, H. Bright, S.M. Evans, and D.J. Lamb Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced asthma mouse model: consequences for steroid sensitivity Clin. Sci. 125 2013 565 574
    • (2013) Clin. Sci. , vol.125 , pp. 565-574
    • Mori, H.1    Parker, N.S.2    Rodrigues, D.3    Hulland, K.4    Chappell, D.5    Hincks, J.S.6    Bright, H.7    Evans, S.M.8    Lamb, D.J.9
  • 62
    • 80051548418 scopus 로고    scopus 로고
    • Asthma translational medicine: report card
    • K. Mullane Asthma translational medicine: report card Biochem. Pharmacol. 82 2011 567 585
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 567-585
    • Mullane, K.1
  • 63
    • 84892374397 scopus 로고    scopus 로고
    • Animal models of asthma: reprise or reboot?
    • K. Mullane, and M. Williams Animal models of asthma: reprise or reboot? Biochem. Pharmacol. 87 2014 131 139
    • (2014) Biochem. Pharmacol. , vol.87 , pp. 131-139
    • Mullane, K.1    Williams, M.2
  • 65
    • 0029820378 scopus 로고    scopus 로고
    • Allergen-specific IgE levels and mite allergen exposure in children with acute asthma first seen in an emergency department and in nonasthmatic control subjects
    • R.P. Nelson Jr., R. DiNicolo, E. Fernandez-Caldas, M.J. Seleznick, R.F. Lockey, and R.A. Good Allergen-specific IgE levels and mite allergen exposure in children with acute asthma first seen in an emergency department and in nonasthmatic control subjects J. Allergy Clin. Immunol. 98 1996 258 263
    • (1996) J. Allergy Clin. Immunol. , vol.98 , pp. 258-263
    • Nelson, Jr.R.P.1    Dinicolo, R.2    Fernandez-Caldas, E.3    Seleznick, M.J.4    Lockey, R.F.5    Good, R.A.6
  • 66
    • 64249119491 scopus 로고    scopus 로고
    • Mouse models of allergic asthma: acute and chronic allergen challenge
    • A.T. Nials, and S. Uddin Mouse models of allergic asthma: acute and chronic allergen challenge Dis. Models Mech. 1 2008 213 220
    • (2008) Dis. Models Mech. , vol.1 , pp. 213-220
    • Nials, A.T.1    Uddin, S.2
  • 67
    • 0026874218 scopus 로고
    • Chronic lower airway disease in the dog and cat
    • P. Padrid Chronic lower airway disease in the dog and cat Probl. Vet. Med. 4 1992 320 344
    • (1992) Probl. Vet. Med. , vol.4 , pp. 320-344
    • Padrid, P.1
  • 68
    • 84897429074 scopus 로고    scopus 로고
    • Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy
    • C. Persson Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy Eur. Respir. J. 43 2014 1208 1211
    • (2014) Eur. Respir. J. , vol.43 , pp. 1208-1211
    • Persson, C.1
  • 69
    • 84896504125 scopus 로고    scopus 로고
    • Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma
    • C. Persson, and L. Uller Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma Am. J. Respir. Crit. Care Med. 189 2014 628 633
    • (2014) Am. J. Respir. Crit. Care Med. , vol.189 , pp. 628-633
    • Persson, C.1    Uller, L.2
  • 70
    • 0036644568 scopus 로고    scopus 로고
    • Con: mice are not a good model of human airway disease
    • discussion 8
    • Persson, C.G., 2002. Con: mice are not a good model of human airway disease. Am. J. Respir. Crit. Care Med. 166, 6-7; discussion 8.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , pp. 6-7
    • Persson, C.G.1
  • 75
    • 0031054773 scopus 로고    scopus 로고
    • Allergic and nonallergic interactions between house dust mite allergens and airway mucosa
    • N. Roche, T.C. Chinet, and G.J. Huchon Allergic and nonallergic interactions between house dust mite allergens and airway mucosa Eur. Respir. J. 10 1997 719 726
    • (1997) Eur. Respir. J. , vol.10 , pp. 719-726
    • Roche, N.1    Chinet, T.C.2    Huchon, G.J.3
  • 76
    • 84885057306 scopus 로고    scopus 로고
    • No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model
    • S. Rochlitzer, H.G. Hoymann, M. Muller, and A. Braun No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model Clin. Sci. 126 2014 55 65
    • (2014) Clin. Sci. , vol.126 , pp. 55-65
    • Rochlitzer, S.1    Hoymann, H.G.2    Muller, M.3    Braun, A.4
  • 79
    • 0032818691 scopus 로고    scopus 로고
    • Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma
    • F.R. Shardonofsky, J. Venzor 3rd, R. Barrios, K.P. Leong, and D.P. Huston Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma J. Allergy Clin. Immunol. 104 1999 215 221
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 215-221
    • Shardonofsky, F.R.1    Venzor, J.2    Barrios, R.3    Leong, K.P.4    Huston, D.P.5
  • 80
    • 84880040870 scopus 로고    scopus 로고
    • Mechanisms of remodeling in asthmatic airways
    • A. Shifren, C. Witt, C. Christie, and M. Castro Mechanisms of remodeling in asthmatic airways J. Allergy 2012 2012 316049
    • (2012) J. Allergy , vol.2012 , pp. 316049
    • Shifren, A.1    Witt, C.2    Christie, C.3    Castro, M.4
  • 82
    • 0142012149 scopus 로고    scopus 로고
    • Mouse model of airway remodeling: strain differences
    • K. Shinagawa, and M. Kojima Mouse model of airway remodeling: strain differences Am. J. Respir. Crit. Care Med. 168 2003 959 967
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , pp. 959-967
    • Shinagawa, K.1    Kojima, M.2
  • 85
    • 79953663682 scopus 로고    scopus 로고
    • Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance
    • C.S. Stevenson, and M.A. Birrell Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance Pharmacol. Ther. 130 2011 93 105
    • (2011) Pharmacol. Ther. , vol.130 , pp. 93-105
    • Stevenson, C.S.1    Birrell, M.A.2
  • 86
    • 0035879347 scopus 로고    scopus 로고
    • Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells
    • G. Sun, M.A. Stacey, M. Schmidt, L. Mori, and S. Mattoli Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells J. Immunol. 167 2001 1014 1021
    • (2001) J. Immunol. , vol.167 , pp. 1014-1021
    • Sun, G.1    Stacey, M.A.2    Schmidt, M.3    Mori, L.4    Mattoli, S.5
  • 87
    • 70449589437 scopus 로고    scopus 로고
    • Mouse models of allergic diseases
    • K. Takeda, and E.W. Gelfand Mouse models of allergic diseases Curr. Opin. Immunol. 21 2009 660 665
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 660-665
    • Takeda, K.1    Gelfand, E.W.2
  • 90
    • 77955300029 scopus 로고    scopus 로고
    • Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
    • L. Uller, M. Leino, N. Bedke, D. Sammut, B. Green, L. Lau, P.H. Howarth, S.T. Holgate, and D.E. Davies Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma Thorax 65 2010 626 632
    • (2010) Thorax , vol.65 , pp. 626-632
    • Uller, L.1    Leino, M.2    Bedke, N.3    Sammut, D.4    Green, B.5    Lau, L.6    Howarth, P.H.7    Holgate, S.T.8    Davies, D.E.9
  • 92
    • 26244464292 scopus 로고    scopus 로고
    • Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    • L. Uller, K. Rydell-Tormanen, C.G. Persson, and J.S. Erjefalt Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation Respir. Res. 6 2005 90
    • (2005) Respir. Res. , vol.6 , pp. 90
    • Uller, L.1    Rydell-Tormanen, K.2    Persson, C.G.3    Erjefalt, J.S.4
  • 94
    • 84878483114 scopus 로고    scopus 로고
    • Global strategies for reducing the burden from asthma a report of a lecture given at The University of Edinburgh, Edinburgh, UK, October 1st 2012
    • O.C.P. van Schayck Global strategies for reducing the burden from asthma a report of a lecture given at The University of Edinburgh, Edinburgh, UK, October 1st 2012 Prim. Care Respir. J. 22 2013 239 243
    • (2013) Prim. Care Respir. J. , vol.22 , pp. 239-243
    • Van Schayck, O.C.P.1
  • 95
    • 0032529608 scopus 로고    scopus 로고
    • IL-5 production by NK cells contributes to eosinophil infiltration in a mouse model of allergic inflammation
    • C. Walker, J. Checkel, S. Cammisuli, P.J. Leibson, and G.J. Gleich IL-5 production by NK cells contributes to eosinophil infiltration in a mouse model of allergic inflammation J. Immunol. 161 1998 1962 1969
    • (1998) J. Immunol. , vol.161 , pp. 1962-1969
    • Walker, C.1    Checkel, J.2    Cammisuli, S.3    Leibson, P.J.4    Gleich, G.J.5
  • 96
    • 0036153548 scopus 로고    scopus 로고
    • Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
    • P.A. Wark, S.L. Johnston, I. Moric, J.L. Simpson, M.J. Hensley, and P.G. Gibson Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma Eur. Respir. J. 19 2002 68 75
    • (2002) Eur. Respir. J. , vol.19 , pp. 68-75
    • Wark, P.A.1    Johnston, S.L.2    Moric, I.3    Simpson, J.L.4    Hensley, M.J.5    Gibson, P.G.6
  • 98
    • 0346121481 scopus 로고    scopus 로고
    • Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity
    • D.C. Webb, S. Mahalingam, Y. Cai, K.I. Matthaei, D.D. Donaldson, and P.S. Foster Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity Eur. J. Immunol. 33 2003 3377 3385
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3377-3385
    • Webb, D.C.1    Mahalingam, S.2    Cai, Y.3    Matthaei, K.I.4    Donaldson, D.D.5    Foster, P.S.6
  • 99
    • 44949229185 scopus 로고    scopus 로고
    • Animal models of chronic experimental asthma - strategies for the identification of new therapeutic targets
    • M. Wegmann Animal models of chronic experimental asthma - strategies for the identification of new therapeutic targets J. Occup. Med. Toxicol. 3 1 2008 S4
    • (2008) J. Occup. Med. Toxicol. , vol.3 , Issue.1 , pp. S4
    • Wegmann, M.1
  • 100
    • 77953117526 scopus 로고    scopus 로고
    • Experimental approaches towards allergic asthma therapy-murine asthma models
    • M. Wegmann, and H.P. Hauber Experimental approaches towards allergic asthma therapy-murine asthma models Recent Pat. Inflamm. Allergy Drug Discov. 4 2010 37 53
    • (2010) Recent Pat. Inflamm. Allergy Drug Discov. , vol.4 , pp. 37-53
    • Wegmann, M.1    Hauber, H.P.2
  • 101
    • 80055050301 scopus 로고    scopus 로고
    • The Wao white book on allergy 2011-2012
    • E.G. Weinberg The Wao white book on allergy 2011-2012 Curr. Allergy Clin. Immunol. 24 2011 156 157
    • (2011) Curr. Allergy Clin. Immunol. , vol.24 , pp. 156-157
    • Weinberg, E.G.1
  • 102
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: it still yields few answers in asthma
    • discussion 1176-1178
    • Wenzel, S., Holgate, S.T., 2006. The mouse trap: it still yields few answers in asthma. Am. J. Respir. Crit. Care Med. 174, 1173-1176; discussion 1176-1178.
    • (2006) Am. J. Respir. Crit. Care Med. , vol.174 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2
  • 103
    • 51349161037 scopus 로고    scopus 로고
    • Factors accounting for asthma variability: achieving optimal symptom control for individual patients
    • B.P. Yawn Factors accounting for asthma variability: achieving optimal symptom control for individual patients Prim. Care Respir. J.: J. Gen. Pract. Airw. Group 17 2008 138 147
    • (2008) Prim. Care Respir. J.: J. Gen. Pract. Airw. Group , vol.17 , pp. 138-147
    • Yawn, B.P.1


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