메뉴 건너뛰기




Volumn 13, Issue 5, 2013, Pages 469-476

Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma

Author keywords

Asthma; Eosinophils; IL 5; Inhibiting; Inhibition; Interleukin 5; Mepolizumab; Severe asthma; Treatment

Indexed keywords

BENRALIZUMAB; CORTICOSTEROID; INTERLEUKIN 5; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; PLACEBO; RESLIZUMAB;

EID: 84885177716     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-013-0379-3     Document Type: Article
Times cited : (11)

References (64)
  • 1
    • 43749108171 scopus 로고    scopus 로고
    • British guideline on the management of asthma
    • British Thoracic Society Scottish Intercollegiate Guidelines Network 10.1136/thx.2008.097741
    • British Thoracic Society Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 2008;4:iv1-121.
    • (2008) Thorax , vol.4 , pp. 1-121
  • 3
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • 16935689 10.1016/S0140-6736(06)69288-X 1:CAS:528:DC%2BD28XoslOjt7o%3D
    • Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 2006;368:780-93.
    • (2006) Lancet , vol.368 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 4
    • 39049170984 scopus 로고    scopus 로고
    • Global strategy for asthma management and prevention: GINA executive summary
    • 18166595 10.1183/09031936.00138707 1:CAS:528:DC%2BD1cXhvVCgsL8%3D
    • Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31:143-78.
    • (2008) Eur Respir J , vol.31 , pp. 143-178
    • Bateman, E.D.1    Hurd, S.S.2    Barnes, P.J.3    Bousquet, J.4    Drazen, J.M.5    Fitzgerald, M.6
  • 5
    • 78049457548 scopus 로고    scopus 로고
    • Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma
    • 20926125 10.1016/j.jaci.2010.07.019
    • Bousquet J, Mantzouranis E, Cruz AA, Ait-Khaled N, Baena-Cagnani CE, Bleecker ER, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126:926-38.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 926-938
    • Bousquet, J.1    Mantzouranis, E.2    Cruz, A.A.3    Ait-Khaled, N.4    Baena-Cagnani, C.E.5    Bleecker, E.R.6
  • 6
    • 82555178613 scopus 로고    scopus 로고
    • Asthma exacerbations: Origin, effect, and prevention
    • 22133317 10.1016/j.jaci.2011.10.024
    • Jackson DJ, Sykes A, Mallia P, Johnston SL. Asthma exacerbations: origin, effect, and prevention. J Allergy Clin Immunol. 2011;128:1165-74.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 1165-1174
    • Jackson, D.J.1    Sykes, A.2    Mallia, P.3    Johnston, S.L.4
  • 7
    • 0028956973 scopus 로고
    • Inhaled glucocorticoids for asthma
    • 7870143 10.1056/NEJM199503303321307 1:STN:280:DyaK2M7nsVynug%3D%3D
    • Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med. 1995;332:868-75.
    • (1995) N Engl J Med , vol.332 , pp. 868-875
    • Barnes, P.J.1
  • 8
    • 0036356493 scopus 로고    scopus 로고
    • Glucocorticoids and asthma
    • 12355712 1:CAS:528:DC%2BD38XnvV2rsLg%3D
    • Barnes PJ. Glucocorticoids and asthma. Ernst Schering Res Found Workshop. 2002;40:1-23.
    • (2002) Ernst Schering Res Found Workshop , vol.40 , pp. 1-23
    • Barnes, P.J.1
  • 9
    • 22144452574 scopus 로고    scopus 로고
    • Severe asthma in adults
    • 15849323 10.1164/rccm.200409-1181PP
    • Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med. 2005;172:149-60.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 149-160
    • Wenzel, S.1
  • 10
    • 33745227751 scopus 로고    scopus 로고
    • Omalizumab for asthma
    • 16790701 10.1056/NEJMct055184 1:CAS:528:DC%2BD28XmtFSgtLY%3D
    • Strunk RC, Bloomberg GR. Omalizumab for asthma. N Engl J Med. 2006;354:2689-95.
    • (2006) N Engl J Med , vol.354 , pp. 2689-2695
    • Strunk, R.C.1    Bloomberg, G.R.2
  • 11
    • 84871370456 scopus 로고    scopus 로고
    • Omalizumab: NICE to USE you, to LOSE you NICE
    • 23229814 10.1136/thoraxjnl-2012-202969
    • Bush A, Pavord ID. Omalizumab: NICE to USE you, to LOSE you NICE. Thorax. 2013;68:7-8.
    • (2013) Thorax , vol.68 , pp. 7-8
    • Bush, A.1    Pavord, I.D.2
  • 12
    • 61849152860 scopus 로고    scopus 로고
    • Eosinophils in asthma - Closing the loop or opening the door?
    • 19264692 10.1056/NEJMe0900334 1:CAS:528:DC%2BD1MXislyhurw%3D
    • Wenzel SE. Eosinophils in asthma - closing the loop or opening the door? N Engl J Med. 2009;360:1026-8.
    • (2009) N Engl J Med , vol.360 , pp. 1026-1028
    • Wenzel, S.E.1
  • 13
    • 0000896565 scopus 로고
    • Beiträge zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen
    • Ehrlich P. Beiträge zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen. Archiv fuer Anatomie und Physiologie: Physiologische Abteilung 1879: 166-169.
    • (1879) Archiv fuer Anatomie und Physiologie: Physiologische Abteilung , pp. 166-169
    • Ehrlich, P.1
  • 14
    • 0030771945 scopus 로고    scopus 로고
    • Human eosinophils
    • 9314336 10.1016/S0091-6749(97)70237-9 1:STN:280:DyaK2svlsl2qsA%3D%3D
    • Weller PF. Human eosinophils. J Allergy Clin Immunol. 1997;100:283-7.
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 283-287
    • Weller, P.F.1
  • 15
    • 34249821341 scopus 로고    scopus 로고
    • Eosinophil trafficking in allergy and asthma
    • 17481712 10.1016/j.jaci.2007.03.048 1:CAS:528:DC%2BD2sXmtlaisLg%3D quiz 1311-2
    • Rosenberg HF, Phipps S, Foster PS. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol. 2007;119:1303-10. quiz 1311-2.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1303-1310
    • Rosenberg, H.F.1    Phipps, S.2    Foster, P.S.3
  • 16
    • 77956643496 scopus 로고    scopus 로고
    • The role of eosinophils in allergic airway inflammation
    • 20423680
    • Walsh ER, Stokes K, August A. The role of eosinophils in allergic airway inflammation. Discov Med. 2010;9:357-62.
    • (2010) Discov Med , vol.9 , pp. 357-362
    • Walsh, E.R.1    Stokes, K.2    August, A.3
  • 18
    • 0024500320 scopus 로고
    • Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro
    • 2923379 10.1164/ajrccm/139.3.801 1:CAS:528:DyaL1MXhsFaltrw%3D
    • Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am Rev Respir Dis. 1989;139:801-5.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 801-805
    • Motojima, S.1    Frigas, E.2    Loegering, D.A.3    Gleich, G.J.4
  • 19
    • 0029945410 scopus 로고    scopus 로고
    • Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild-moderate, stable asthma
    • 8738515 1:STN:280:DyaK28zltVKlsw%3D%3D
    • Oddera S, Silvestri M, Balbo A, Jovovich BO, Penna R, Crimi E, et al. Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild-moderate, stable asthma. Allergy. 1996;51:100-7.
    • (1996) Allergy , vol.51 , pp. 100-107
    • Oddera, S.1    Silvestri, M.2    Balbo, A.3    Jovovich, B.O.4    Penna, R.5    Crimi, E.6
  • 20
    • 0027056728 scopus 로고
    • Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast cultures
    • 1493801 1:STN:280:DyaK3s7lsVeltg%3D%3D
    • Hernnas J, Sarnstrand B, Lindroth P, Peterson CG, Venge P, Malmstrom A. Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast cultures. Eur J Cell Biol. 1992;59:352-63.
    • (1992) Eur J Cell Biol , vol.59 , pp. 352-363
    • Hernnas, J.1    Sarnstrand, B.2    Lindroth, P.3    Peterson, C.G.4    Venge, P.5    Malmstrom, A.6
  • 21
    • 4544274172 scopus 로고    scopus 로고
    • A critical role for eosinophils in allergic airways remodeling
    • 15375268 10.1126/science.1100283 1:CAS:528:DC%2BD2cXnsFajtbY%3D
    • Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, et al. A critical role for eosinophils in allergic airways remodeling. Science. 2004;305:1776-9.
    • (2004) Science , vol.305 , pp. 1776-1779
    • Humbles, A.A.1    Lloyd, C.M.2    McMillan, S.J.3    Friend, D.S.4    Xanthou, G.5    McKenna, E.E.6
  • 22
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • 10471631 10.1164/ajrccm.160.3.9812110 1:STN:280:DyaK1Mvgtlanuw%3D%3D
    • Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160:1001-8.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6
  • 23
    • 85047693849 scopus 로고    scopus 로고
    • Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • 14523040 1:CAS:528:DC%2BD3sXnvFGrsLg%3D
    • Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest. 2003;112:1029-36.
    • (2003) J Clin Invest , vol.112 , pp. 1029-1036
    • Flood-Page, P.1    Menzies-Gow, A.2    Phipps, S.3    Ying, S.4    Wangoo, A.5    Ludwig, M.S.6
  • 24
    • 0028930486 scopus 로고
    • Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation
    • 7706481 10.1172/JCI117850 1:CAS:528:DyaK2MXkslyktL0%3D
    • Coyle AJ, Ackerman SJ, Burch R, Proud D, Irvin CG. Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation. J Clin Invest. 1995;95:1735-40.
    • (1995) J Clin Invest , vol.95 , pp. 1735-1740
    • Coyle, A.J.1    Ackerman, S.J.2    Burch, R.3    Proud, D.4    Irvin, C.G.5
  • 25
    • 4544304222 scopus 로고    scopus 로고
    • Defining a link with asthma in mice congenitally deficient in eosinophils
    • 15375267 10.1126/science.1099472 1:CAS:528:DC%2BD2cXnsFajtbk%3D
    • Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004;305:1773-6.
    • (2004) Science , vol.305 , pp. 1773-1776
    • Lee, J.J.1    Dimina, D.2    Macias, M.P.3    Ochkur, S.I.4    McGarry, M.P.5    O'Neill, K.R.6
  • 26
    • 0023831561 scopus 로고
    • Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity
    • 2447813 10.1164/ajrccm/137.1.62 1:STN:280:DyaL1c7gsV2jtA%3D%3D
    • Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis. 1988;137:62-9.
    • (1988) Am Rev Respir Dis , vol.137 , pp. 62-69
    • Wardlaw, A.J.1    Dunnette, S.2    Gleich, G.J.3    Collins, J.V.4    Kay, A.B.5
  • 27
    • 0034445294 scopus 로고    scopus 로고
    • Eosinophils in asthma and other allergic diseases
    • 11359633 10.1258/0007142001903490 1:CAS:528:DC%2BD3MXktVOmtb0%3D
    • Wardlaw AJ, Brightling C, Green R, Woltmann G, Pavord I. Eosinophils in asthma and other allergic diseases. Br Med Bull. 2000;56:985-1003.
    • (2000) Br Med Bull , vol.56 , pp. 985-1003
    • Wardlaw, A.J.1    Brightling, C.2    Green, R.3    Woltmann, G.4    Pavord, I.5
  • 28
    • 20144386778 scopus 로고    scopus 로고
    • Asthma Clinical Research Network, National Heart, Lung, and Blood Institute/NIH. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    • 15805990 10.1016/j.jaci.2004.12.1129 1:CAS:528:DC%2BD2MXivV2ju7c%3D
    • Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, et al. Asthma Clinical Research Network, National Heart, Lung, and Blood Institute/NIH. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005;115:720-7.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 720-727
    • Deykin, A.1    Lazarus, S.C.2    Fahy, J.V.3    Wechsler, M.E.4    Boushey, H.A.5    Chinchilli, V.M.6
  • 29
    • 0035131758 scopus 로고    scopus 로고
    • Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids
    • 11179114 10.1164/ajrccm.163.2.9912091 1:STN:280:DC%2BD3M7ot1Ogug%3D%3D
    • Leuppi JD, Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, et al. Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. Am J Respir Crit Care Med. 2001;163:406-12.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 406-412
    • Leuppi, J.D.1    Salome, C.M.2    Jenkins, C.R.3    Anderson, S.D.4    Xuan, W.5    Marks, G.B.6
  • 30
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
    • 12480423 10.1016/S0140-6736(02)11679-5
    • Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002;360:1715-21.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6
  • 31
    • 33646787430 scopus 로고    scopus 로고
    • Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma
    • 16749408 10.1177/147323000603400202 1:STN:280:DC%2BD28zivFaqsg%3D%3D
    • Chlumsky J, Striz I, Terl M, Vondracek J. Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma. J Int Med Res. 2006;34:129-39.
    • (2006) J Int Med Res , vol.34 , pp. 129-139
    • Chlumsky, J.1    Striz, I.2    Terl, M.3    Vondracek, J.4
  • 32
    • 82355162913 scopus 로고    scopus 로고
    • Interleukin-5 and IL-5 receptor in health and diseases
    • 21986312 10.2183/pjab.87.463 1:CAS:528:DC%2BC38XhtFCiu7c%3D
    • Takatsu K. Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:463-85.
    • (2011) Proc Jpn Acad ser B Phys Biol Sci , vol.87 , pp. 463-485
    • Takatsu, K.1
  • 33
    • 1542555091 scopus 로고
    • Eosinophil differentiation factor also has B-cell growth factor activity: Proposed name interleukin 4
    • 3484551 10.1073/pnas.83.2.437 1:CAS:528:DyaL28XhtVOlt7k%3D
    • Sanderson CJ, O'Garra A, Warren DJ, Klaus GG. Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4. Proc Natl Acad Sci U S A. 1986;83:437-40.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 437-440
    • Sanderson, C.J.1    O'Garra, A.2    Warren, D.J.3    Klaus, G.G.4
  • 34
    • 0024582587 scopus 로고
    • Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5
    • 2564789
    • van Leeuwen BH, Martinson ME, Webb GC, Young IG. Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5. Blood. 1989;73:1142-8.
    • (1989) Blood , vol.73 , pp. 1142-1148
    • Van Leeuwen, B.H.1    Martinson, M.E.2    Webb, G.C.3    Young, I.G.4
  • 35
    • 0027489710 scopus 로고
    • Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5
    • 8400249 1:CAS:528:DyaK3sXms1ygs7o%3D
    • Miyajima A, Mui AL, Ogorochi T, Sakamaki K. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood. 1993;82:1960-74.
    • (1993) Blood , vol.82 , pp. 1960-1974
    • Miyajima, A.1    Mui, A.L.2    Ogorochi, T.3    Sakamaki, K.4
  • 36
    • 0025036906 scopus 로고
    • Eosinophilia in transgenic mice expressing interleukin 5
    • 2230651 10.1084/jem.172.5.1425 1:CAS:528:DyaK3cXlslSitbY%3D
    • Dent LA, Strath M, Mellor AL, Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med. 1990;172:1425-31.
    • (1990) J Exp Med , vol.172 , pp. 1425-1431
    • Dent, L.A.1    Strath, M.2    Mellor, A.L.3    Sanderson, C.J.4
  • 37
    • 0025159184 scopus 로고
    • Regulatory effect of cytokines on eosinophil degranulation
    • 2104901 1:CAS:528:DyaK3cXhtFOisrs%3D
    • Fujisawa T, Abu-Ghazaleh R, Kita H, Sanderson CJ, Gleich GJ. Regulatory effect of cytokines on eosinophil degranulation. J Immunol. 1990;144:642-6.
    • (1990) J Immunol , vol.144 , pp. 642-646
    • Fujisawa, T.1    Abu-Ghazaleh, R.2    Kita, H.3    Sanderson, C.J.4    Gleich, G.J.5
  • 38
    • 0025169452 scopus 로고
    • IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner
    • 2228026 1:CAS:528:DyaK3cXmt12gs7Y%3D
    • Walsh GM, Hartnell A, Wardlaw AJ, Kurihara K, Sanderson CJ, Kay AB. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology. 1990;71:258-65.
    • (1990) Immunology , vol.71 , pp. 258-265
    • Walsh, G.M.1    Hartnell, A.2    Wardlaw, A.J.3    Kurihara, K.4    Sanderson, C.J.5    Kay, A.B.6
  • 39
    • 0035184832 scopus 로고    scopus 로고
    • Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma
    • 11713356 10.1136/thorax.56.12.935
    • van Rensen EL, Stirling RG, Scheerens J, Staples K, Sterk PJ, Barnes PJ, et al. Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax. 2001;56:935-40.
    • (2001) Thorax , vol.56 , pp. 935-940
    • Van Rensen, E.L.1    Stirling, R.G.2    Scheerens, J.3    Staples, K.4    Sterk, P.J.5    Barnes, P.J.6
  • 40
    • 0031093025 scopus 로고    scopus 로고
    • Infiltration of eosinophils into the asthmatic airways caused by interleukin 5
    • 9070605 10.1165/ajrcmb.16.3.9070605 1:CAS:528:DyaK2sXitV2itbk%3D
    • Shi H, Qin S, Huang G, Chen Y, Xiao C, Xu H, et al. Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. Am J Respir Cell Mol Biol. 1997;16:220-4.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 220-224
    • Shi, H.1    Qin, S.2    Huang, G.3    Chen, Y.4    Xiao, C.5    Xu, H.6
  • 41
    • 0024330415 scopus 로고
    • IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity
    • 2506282 1:CAS:528:DyaL1MXmtFejur8%3D
    • Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, et al. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol. 1989;143:2311-6.
    • (1989) J Immunol , vol.143 , pp. 2311-2316
    • Rothenberg, M.E.1    Petersen, J.2    Stevens, R.L.3    Silberstein, D.S.4    McKenzie, D.T.5    Austen, K.F.6
  • 42
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • 8551223 10.1084/jem.183.1.195 1:CAS:528:DyaK28XjsVCgtQ%3D%3D
    • Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med. 1996;183:195-201.
    • (1996) J Exp Med , vol.183 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 43
    • 3042714189 scopus 로고    scopus 로고
    • Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice
    • 14975941 10.1165/rcmb.2003-0305OC 1:CAS:528:DC%2BD2cXlsFKjsb8%3D
    • Tanaka H, Komai M, Nagao K, Ishizaki M, Kajiwara D, Takatsu K, et al. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol. 2004;31:62-8.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 62-68
    • Tanaka, H.1    Komai, M.2    Nagao, K.3    Ishizaki, M.4    Kajiwara, D.5    Takatsu, K.6
  • 44
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • 11191542 10.1016/S0140-6736(00)03496-6 1:CAS:528:DC%2BD3MXitlGgsg%3D%3D
    • Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144-8.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.J.5    Walls, C.M.6
  • 45
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • 12406833 10.1164/rccm.200208-789OC
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med. 2003;167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 46
    • 36749065556 scopus 로고    scopus 로고
    • International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • 17872493 10.1164/rccm.200701-085OC 1:CAS:528:DC%2BD1cXhvFSgtQ%3D%3D
    • Flood-Page P, Swenson C, Faiferman I, Matthews J, Williams M, Brannick L, et al. International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med. 2007;176:1062-71.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3    Matthews, J.4    Williams, M.5    Brannick, L.6
  • 47
    • 0033616466 scopus 로고    scopus 로고
    • Differences between asthma exacerbations and poor asthma control
    • 9950442 10.1016/S0140-6736(98)06128-5 1:STN:280:DyaK1M7jtl2nsw%3D%3D
    • Reddel H, Ware S, Marks G, Salome C, Jenkins C, Woolcock A. Differences between asthma exacerbations and poor asthma control. Lancet. 1999;353:364-9.
    • (1999) Lancet , vol.353 , pp. 364-369
    • Reddel, H.1    Ware, S.2    Marks, G.3    Salome, C.4    Jenkins, C.5    Woolcock, A.6
  • 48
    • 1842370350 scopus 로고    scopus 로고
    • Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma
    • 9358137 10.1056/NEJM199711133372001 1:CAS:528:DyaK2sXnsVynuro%3D
    • Pauwels RA, Löfdahl C, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, et al. Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma. N Engl J Med. 1997;337:1405-11.
    • (1997) N Engl J Med , vol.337 , pp. 1405-1411
    • Pauwels, R.A.1    Löfdahl, C.2    Postma, D.S.3    Tattersfield, A.E.4    O'Byrne, P.5    Barnes, P.J.6
  • 49
    • 33344476409 scopus 로고    scopus 로고
    • Determining asthma treatment by monitoring sputum cell counts: Effect on exacerbations
    • 16507847 10.1183/09031936.06.00137704 1:STN:280:DC%2BD287itVKlug%3D%3D
    • Jayaram L, Pizzichini MM, Cook RJ, Boulet LP, Lemiere C, Pizzichini E, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J. 2006;27:483-94.
    • (2006) Eur Respir J , vol.27 , pp. 483-494
    • Jayaram, L.1    Pizzichini, M.M.2    Cook, R.J.3    Boulet, L.P.4    Lemiere, C.5    Pizzichini, E.6
  • 50
    • 33750685972 scopus 로고    scopus 로고
    • Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    • 16455831 10.1183/09031936.06.00102605 1:CAS:528:DC%2BD28XlvF2htr0%3D
    • Green RH, Brightling CE, McKenna S, Hargadon B, Neale N, Parker D, et al. Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Eur Respir J. 2006;27:1144-51.
    • (2006) Eur Respir J , vol.27 , pp. 1144-1151
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Neale, N.5    Parker, D.6
  • 51
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • 19264687 10.1056/NEJMoa0805435 1:CAS:528:DC%2BD1MXislOlsLg%3D
    • Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985-93.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3    Inman, M.D.4    Efthimiadis, A.5    Pizzichini, E.6
  • 52
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • 19264686 10.1056/NEJMoa0808991 1:CAS:528:DC%2BD1MXislOlsLs%3D
    • Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973-84.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3    Gupta, S.4    Monteiro, W.5    Sousa, A.6
  • 53
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • 22901886 10.1016/S0140-6736(12)60988-X 1:CAS:528:DC%2BC38Xht1aksLfE This large multicenter RCT showed clear effect of mepolizumab on severe exacerbation frequency in severe eosinophilic asthmatics
    • •• Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380:651-9. This large multicenter RCT showed clear effect of mepolizumab on severe exacerbation frequency in severe eosinophilic asthmatics.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 54
    • 84875467652 scopus 로고    scopus 로고
    • Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: A meta-analysis of randomized placebo-controlled trials
    • 23544105 10.1371/journal.pone.0059872 1:CAS:528:DC%2BC3sXlvVOqtLY%3D A recent large meta-analysis summarising RCT on the use of mepolizumab in asthmatics
    • • Liu Y, Zhang S, Li DW, Jiang SJ. Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials. PLoS One. 2013;8:e59872. A recent large meta-analysis summarising RCT on the use of mepolizumab in asthmatics.
    • (2013) PLoS One , vol.8 , pp. 59872
    • Liu, Y.1    Zhang, S.2    Li, D.W.3    Jiang, S.J.4
  • 55
    • 81455155725 scopus 로고    scopus 로고
    • Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • 21852542 10.1164/rccm.201103-0396OC 1:CAS:528:DC%2BC3MXhs1ejsLnL
    • Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, et al. Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011;184:1125-32.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Boulet, L.P.4    Xie, F.5    Young, J.6
  • 56
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase i study of subjects with mild asthma
    • 20513521 10.1016/j.jaci.2010.04.005 1:CAS:528:DC%2BC3cXmslekur0%3D
    • Busse WW, Katial R, Gossage D, Sari S, Wang B, Kolbeck R, et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol. 2010;125:1237-1244.e2.
    • (2010) J Allergy Clin Immunol , vol.125
    • Busse, W.W.1    Katial, R.2    Gossage, D.3    Sari, S.4    Wang, B.5    Kolbeck, R.6
  • 57
    • 84055199162 scopus 로고    scopus 로고
    • Benralizumab - A humanized mAb to IL-5Ralpha with enhanced antibody-dependent cell-mediated cytotoxicity - A novel approach for the treatment of asthma
    • 22136436 10.1517/14712598.2012.642359 1:CAS:528:DC%2BC3MXhs1Cju7jK
    • Ghazi A, Trikha A, Calhoun WJ. Benralizumab - a humanized mAb to IL-5Ralpha with enhanced antibody-dependent cell-mediated cytotoxicity - a novel approach for the treatment of asthma. Expert Opin Biol Ther. 2012;12:113-8.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 113-118
    • Ghazi, A.1    Trikha, A.2    Calhoun, W.J.3
  • 58
    • 0036528907 scopus 로고    scopus 로고
    • Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma
    • 11934731 10.1164/ajrccm.165.7.2109095
    • Allakhverdi Z, Allam M, Renzi PM. Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. Am J Respir Crit Care Med. 2002;165:1015-21.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1015-1021
    • Allakhverdi, Z.1    Allam, M.2    Renzi, P.M.3
  • 59
    • 42949132127 scopus 로고    scopus 로고
    • Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    • 18244953 10.1164/rccm.200708-1251OC 1:CAS:528:DC%2BD1cXms1Ohs7Y%3D
    • Gauvreau GM, Boulet LP, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, et al. Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses. Am J Respir Crit Care Med. 2008;177:952-8.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 952-958
    • Gauvreau, G.M.1    Boulet, L.P.2    Cockcroft, D.W.3    Baatjes, A.4    Cote, J.5    Deschesnes, F.6
  • 60
    • 42149136164 scopus 로고    scopus 로고
    • Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness
    • 18305576 10.1038/gt.2008.15 1:CAS:528:DC%2BD1cXks12kt7c%3D
    • Huang H, Lee C, Chiang B. Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness. Gene Ther. 2008;15:660-7.
    • (2008) Gene Ther , vol.15 , pp. 660-667
    • Huang, H.1    Lee, C.2    Chiang, B.3
  • 61
    • 40949146020 scopus 로고    scopus 로고
    • Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    • 18344568 10.1056/NEJMoa070812 1:CAS:528:DC%2BD1cXjvVWhsL4%3D
    • Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, et al. Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008;358:1215-28.
    • (2008) N Engl J Med , vol.358 , pp. 1215-1228
    • Rothenberg, M.E.1    Klion, A.D.2    Roufosse, F.E.3    Kahn, J.E.4    Weller, P.F.5    Simon, H.U.6
  • 63
    • 70349955002 scopus 로고    scopus 로고
    • Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD
    • 19478474 10.1159/000221902 1:CAS:528:DC%2BD1MXhtFyhtb3I
    • Bafadhel M, Saha S, Siva R, McCormick M, Monteiro W, Rugman P, et al. Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD. Respiration. 2009;78:256-62.
    • (2009) Respiration , vol.78 , pp. 256-262
    • Bafadhel, M.1    Saha, S.2    Siva, R.3    McCormick, M.4    Monteiro, W.5    Rugman, P.6
  • 64
    • 70349931756 scopus 로고    scopus 로고
    • Exhaled nitric oxide in diagnosis and management of respiratory diseases
    • 19881162 10.4103/1817-1737.56009
    • Abba AA. Exhaled nitric oxide in diagnosis and management of respiratory diseases. Ann Thorac Med. 2009;4:173-81.
    • (2009) Ann Thorac Med , vol.4 , pp. 173-181
    • Abba, A.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.