Are mouse models of allergic asthma useful for testing novel therapeutics?

Experimental and Toxicologic Pathology

Volumn 57, Issue SUPPL. 2, 2006, Pages 41-44

  Epstein, Michelle M ^a  

^a Division of Infectious Diseases   (Austria)

Author keywords

Asthma bronchiale; Drug testing; Mouse models; Novel therapeutics; T cells

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; SILVER;

ALLERGIC ASTHMA; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; MEMORY CELL; MOUSE; NONHUMAN; PROPHYLAXIS; TH2 CELL;

EID: 33646780264     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2006.02.005     Document Type: Article

References (7)

1. Epstein M.M. Do mouse models of allergic asthma mimic clinical disease?. Int Arch Allergy Immunol 133 (2004) 84-100
2. Epstein M.M. Modeling allergic asthma: in vitro assays to virtual patients Drug Discovery Today. Disease Models 1 (2004) 387-394
3. Graffi S., Dekan G., Stingl G., and Epstein M.M. Systemic administration of antigen-pulsed dendritic cells induces experimental allergic asthma in mice upon aerosol antigen rechallenge. Clin Immunol 103 (2002) 176-184
4. Jungsuwadee P., Dekan G., Stingl G., and Epstein M.M. Recurrent aerosol antigen exposure induces distinct patterns of experimental allergic asthma in mice. Clin Immunol 102 (2002) 145-153
5. Jungsuwadee P., Dekan G., Stingl G., and Epstein M.M. Inhaled dexamethasone differentially attenuates disease relapse and established allergic asthma in mice. Clin Immunol 110 (2004) 101-108
6. Jungsuwadee P., Benkovszky M., Dekan G., Stingl G., and Epstein M.M. Repeated aerosol allergen exposure suppresses inflammation in B cell deficient mice with established allergic asthma. Int Arch Allergy Immunol 133 (2004) 40-48
7. Mojtabavi N., Dekan G., Stingl G., and Epstein M.M. Long-lived Th2 memory in experimental allergic asthma. J Immunol 169 (2002) 4788-4796