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Volumn 20, Issue 5, 2015, Pages 588-594

The coming of age of engineered multivalent antibodies

Author keywords

[No Author keywords available]

Indexed keywords

BISPECIFIC ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY;

EID: 84937759650     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.02.013     Document Type: Review
Times cited : (108)

References (82)
  • 1
    • 20444365508 scopus 로고    scopus 로고
    • Antibody engineering: Facing new challenges in cancer therapy
    • L. Sanz Antibody engineering: facing new challenges in cancer therapy Acta Pharmacol. Sin. 26 2005 641 648
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 641-648
    • Sanz, L.1
  • 2
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: The neonatal Fc receptor comes of age
    • D.C. Roopenian, and S. Akilesh FcRn: the neonatal Fc receptor comes of age Nat. Rev. Immunol. 7 2007 715 725
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 3
    • 0842303168 scopus 로고    scopus 로고
    • Antibodies and gene therapy: Teaching old 'magic bullets' new tricks
    • L. Sanz Antibodies and gene therapy: teaching old 'magic bullets' new tricks Trends Immunol. 25 2004 85 91
    • (2004) Trends Immunol. , vol.25 , pp. 85-91
    • Sanz, L.1
  • 4
    • 84903581591 scopus 로고    scopus 로고
    • Antibodies to watch in 2014: Mid-year update
    • J.M. Reichert Antibodies to watch in 2014: mid-year update MAbs 6 2014 799 802
    • (2014) MAbs , vol.6 , pp. 799-802
    • Reichert, J.M.1
  • 5
    • 84858785688 scopus 로고    scopus 로고
    • Antibody therapy of cancer
    • A.M. Scott Antibody therapy of cancer Nat. Rev. Cancer 12 2012 278 287
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 278-287
    • Scott, A.M.1
  • 6
    • 62149129236 scopus 로고    scopus 로고
    • Therapeutic antibodies: Successes, limitations and hopes for the future
    • P. Chames Therapeutic antibodies: successes, limitations and hopes for the future Br. J. Pharmacol. 157 2009 220 233
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 220-233
    • Chames, P.1
  • 7
    • 84865455090 scopus 로고    scopus 로고
    • The future of antibodies as cancer drugs
    • J.M. Reichert, and E. Dhimolea The future of antibodies as cancer drugs Drug Discov. Today 17 2012 954 963
    • (2012) Drug Discov. Today , vol.17 , pp. 954-963
    • Reichert, J.M.1    Dhimolea, E.2
  • 8
    • 35548955496 scopus 로고    scopus 로고
    • Fc receptors as regulators of immunity
    • F. Nimmeejahn, and J.V. Ravetch Fc receptors as regulators of immunity Adv. Immunol. 96 2007 179 204
    • (2007) Adv. Immunol. , vol.96 , pp. 179-204
    • Nimmeejahn, F.1    Ravetch, J.V.2
  • 9
    • 79551575923 scopus 로고    scopus 로고
    • Advances in the assessment and control of the effector functions of therapeutic antibodies
    • X.R. Jiang Advances in the assessment and control of the effector functions of therapeutic antibodies Nat. Rev. Drug Discov. 10 2011 101 111
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 101-111
    • Jiang, X.R.1
  • 10
    • 67649843650 scopus 로고    scopus 로고
    • Strategies to extend plasma half-lives of recombinant antibodies
    • R.E. Kontermann Strategies to extend plasma half-lives of recombinant antibodies BioDrugs 23 2009 93 109
    • (2009) BioDrugs , vol.23 , pp. 93-109
    • Kontermann, R.E.1
  • 11
    • 60849113728 scopus 로고    scopus 로고
    • Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins
    • A. Beck Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins Curr. Pharm. Biotechnol. 9 2008 482 501
    • (2008) Curr. Pharm. Biotechnol. , vol.9 , pp. 482-501
    • Beck, A.1
  • 12
    • 33846215917 scopus 로고    scopus 로고
    • Antibody constructs in cancer therapy: Protein engineering strategies to improve exposure in solid tumors
    • R.A. Beckman Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors Cancer 109 2007 170 179
    • (2007) Cancer , vol.109 , pp. 170-179
    • Beckman, R.A.1
  • 13
    • 77955690974 scopus 로고    scopus 로고
    • Multivalent antibodies: When design surpasses evolution
    • A.M. Cuesta Multivalent antibodies: when design surpasses evolution Trends Biotechnol. 28 2010 355 362
    • (2010) Trends Biotechnol. , vol.28 , pp. 355-362
    • Cuesta, A.M.1
  • 14
    • 82755197856 scopus 로고    scopus 로고
    • Strategies for extended serum half-life of protein therapeutics
    • R.E. Kontermann Strategies for extended serum half-life of protein therapeutics Curr. Opin. Biotechnol. 22 2011 868 876
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 868-876
    • Kontermann, R.E.1
  • 15
    • 80053438315 scopus 로고    scopus 로고
    • Non-immunoglobulin based protein scaffolds
    • J. Löfblom Non-immunoglobulin based protein scaffolds Curr. Opin. Biotechnol. 22 2011 843 848
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 843-848
    • Löfblom, J.1
  • 16
    • 84880545300 scopus 로고    scopus 로고
    • Replacing antibodies: Engineering new binding proteins
    • S. Banta Replacing antibodies: engineering new binding proteins Annu. Rev. Biomed. Eng. 15 2010 93 113
    • (2010) Annu. Rev. Biomed. Eng. , vol.15 , pp. 93-113
    • Banta, S.1
  • 17
    • 0033929947 scopus 로고    scopus 로고
    • Single-chain antibodies against human insulin-like growth factor i receptor: Expression, purification, and effect on tumor growth
    • S.L. Li Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth Cancer Immunol. Immunother. 49 2000 243 252
    • (2000) Cancer Immunol. Immunother. , vol.49 , pp. 243-252
    • Li, S.L.1
  • 18
    • 0029890636 scopus 로고    scopus 로고
    • Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts
    • S. Hu Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts Cancer Res. 56 1996 3055 3061
    • (1996) Cancer Res. , vol.56 , pp. 3055-3061
    • Hu, S.1
  • 19
    • 84867000911 scopus 로고    scopus 로고
    • The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity
    • O. Steifert The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity Protein Eng. Des. Sel. 25 2012 603 612
    • (2012) Protein Eng. Des. Sel. , vol.25 , pp. 603-612
    • Steifert, O.1
  • 20
    • 84892607590 scopus 로고    scopus 로고
    • Tetravalent antibody-scTRAIL fusion proteins with improved properties
    • O. Steifert Tetravalent antibody-scTRAIL fusion proteins with improved properties Mol. Cancer Ther. 13 2014 101 111
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 101-111
    • Steifert, O.1
  • 21
    • 77951532100 scopus 로고    scopus 로고
    • Covalent dimerization of camelidae anti-human TNF-alpha single domain antibodies by the constant kappa light chain domain improves neutralizing activity
    • M. Giersberg Covalent dimerization of camelidae anti-human TNF-alpha single domain antibodies by the constant kappa light chain domain improves neutralizing activity Biotechnol. Bioeng. 106 2010 161 166
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 161-166
    • Giersberg, M.1
  • 22
    • 84896499135 scopus 로고    scopus 로고
    • Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library
    • S. Miethe Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library MAbs 6 2014 446 459
    • (2014) MAbs , vol.6 , pp. 446-459
    • Miethe, S.1
  • 23
    • 84895077137 scopus 로고    scopus 로고
    • Bispecific Her2 × cotinine antibody in combination with cotinine-(histidine)2-iodine for the pre-targeting of Her2-positive breast cancer xenografts
    • S. Yoon Bispecific Her2 × cotinine antibody in combination with cotinine-(histidine)2-iodine for the pre-targeting of Her2-positive breast cancer xenografts J. Cancer Res. Clin. Oncol. 140 2014 227 233
    • (2014) J. Cancer Res. Clin. Oncol. , vol.140 , pp. 227-233
    • Yoon, S.1
  • 24
    • 84885922197 scopus 로고    scopus 로고
    • Production and characterization of a CD25-specific scFv-Fc antibody secreted from Pichia pastoris
    • L. Wan Production and characterization of a CD25-specific scFv-Fc antibody secreted from Pichia pastoris Appl. Microbiol. Biotechnol. 97 2013 3855 3860
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 3855-3860
    • Wan, L.1
  • 25
    • 84937764570 scopus 로고    scopus 로고
    • Generation of 1E8 single chain Fv-Fc construct against human CD59
    • J.W. Jong Generation of 1E8 single chain Fv-Fc construct against human CD59 Immune Netw. 12 2012 33 39
    • (2012) Immune Netw. , vol.12 , pp. 33-39
    • Jong, J.W.1
  • 26
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • P.R. Johnson Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys Nat. Med. 15 2009 901 906
    • (2009) Nat. Med. , vol.15 , pp. 901-906
    • Johnson, P.R.1
  • 27
    • 84855446659 scopus 로고    scopus 로고
    • Single-chain Fv-based anti-HIV proteins: Potential and limitations
    • A.P. West Jr. Single-chain Fv-based anti-HIV proteins: potential and limitations J. Virol. 86 2012 195 202
    • (2012) J. Virol. , vol.86 , pp. 195-202
    • West, Jr.A.P.1
  • 28
    • 58149343901 scopus 로고    scopus 로고
    • Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors
    • J.V. Leyton Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors Clin. Cancer Res. 14 2008 7488 7496
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7488-7496
    • Leyton, J.V.1
  • 29
    • 77956187731 scopus 로고    scopus 로고
    • An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors
    • E.J. Lepin An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors Eur. J. Nucl. Med. Mol. Imaging 37 2010 1529 1538
    • (2010) Eur. J. Nucl. Med. Mol. Imaging , vol.37 , pp. 1529-1538
    • Lepin, E.J.1
  • 30
    • 84899483754 scopus 로고    scopus 로고
    • Quantitative immunoPET of prostate cancer xenografts with 89Zr- and 124I-labeled anti-PSCA A11 minibody
    • S.M. Knowles Quantitative immunoPET of prostate cancer xenografts with 89Zr- and 124I-labeled anti-PSCA A11 minibody J. Nucl. Med. 55 2014 452 459
    • (2014) J. Nucl. Med. , vol.55 , pp. 452-459
    • Knowles, S.M.1
  • 31
    • 69449105856 scopus 로고    scopus 로고
    • Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas
    • T. Olafsen Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas J. Nucl. Med. 50 2009 1500 1508
    • (2009) J. Nucl. Med. , vol.50 , pp. 1500-1508
    • Olafsen, T.1
  • 32
    • 84892912236 scopus 로고    scopus 로고
    • Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo
    • R. Tavaré Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo Proc. Natl. Acad. Sci. U. S. A. 21 2014 1108 1113
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.21 , pp. 1108-1113
    • Tavaré, R.1
  • 33
    • 84866006613 scopus 로고    scopus 로고
    • Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma
    • T. Han Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma PLOS ONE 7 2012 e44455
    • (2012) PLOS ONE , vol.7 , pp. e44455
    • Han, T.1
  • 34
    • 0030822851 scopus 로고    scopus 로고
    • Mammalian cell expression of dimeric small immune proteins (SIP)
    • E. Li Mammalian cell expression of dimeric small immune proteins (SIP) Protein Eng. 10 1997 731 736
    • (1997) Protein Eng. , vol.10 , pp. 731-736
    • Li, E.1
  • 35
    • 0031942064 scopus 로고    scopus 로고
    • Construction of mono- and bivalent human single-chain Fv fragments against the D antigen in the Rh blood group: Multimerization effect on cell agglutination and application to blood typing
    • M. Furuta Construction of mono- and bivalent human single-chain Fv fragments against the D antigen in the Rh blood group: multimerization effect on cell agglutination and application to blood typing Protein Eng. 11 1998 233 241
    • (1998) Protein Eng. , vol.11 , pp. 233-241
    • Furuta, M.1
  • 36
    • 11144238604 scopus 로고    scopus 로고
    • Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format
    • L.S. Shahied Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format J. Biol. Chem. 279 2004 53907 53914
    • (2004) J. Biol. Chem. , vol.279 , pp. 53907-53914
    • Shahied, L.S.1
  • 37
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • P. Holliger, and P.J. Hudson Engineered antibody fragments and the rise of single domains Nat. Biotechnol. 23 2005 1126 1136
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 38
    • 84899473717 scopus 로고    scopus 로고
    • Nanobody-based products as research and diagnostic tools
    • T. De Meyer Nanobody-based products as research and diagnostic tools Trends Biotechnol. 32 2014 263 270
    • (2014) Trends Biotechnol. , vol.32 , pp. 263-270
    • De Meyer, T.1
  • 39
    • 0027197493 scopus 로고
    • 'Diabodies': Small bivalent and bispecific antibody fragments
    • P. Holliger 'Diabodies': small bivalent and bispecific antibody fragments Proc. Natl. Acad. Sci. U. S. A. 90 1993 6444 6448
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 6444-6448
    • Holliger, P.1
  • 40
    • 0030748513 scopus 로고    scopus 로고
    • Triabodies: Single chain Fv fragments without a linker form trivalent trimers
    • P. Iliades Triabodies: single chain Fv fragments without a linker form trivalent trimers FEBS Lett. 409 1997 437 441
    • (1997) FEBS Lett. , vol.409 , pp. 437-441
    • Iliades, P.1
  • 41
    • 0035251638 scopus 로고    scopus 로고
    • Design and application of diabodies, triabodies and tetrabodies for cancer targeting
    • A. Todorovska Design and application of diabodies, triabodies and tetrabodies for cancer targeting J. Immunol. Methods 248 2001 47 66
    • (2001) J. Immunol. Methods , vol.248 , pp. 47-66
    • Todorovska, A.1
  • 42
    • 0037436345 scopus 로고    scopus 로고
    • The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: Implications for diabody flexibility
    • J.A. Carmichael The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility J. Mol. Biol. 326 2003 341 351
    • (2003) J. Mol. Biol. , vol.326 , pp. 341-351
    • Carmichael, J.A.1
  • 43
    • 0033569478 scopus 로고    scopus 로고
    • Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
    • S.M. Kipriyanov Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics J. Mol. Biol. 293 1999 41 56
    • (1999) J. Mol. Biol. , vol.293 , pp. 41-56
    • Kipriyanov, S.M.1
  • 44
    • 0035664509 scopus 로고    scopus 로고
    • Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain diabodies
    • T. Völkel Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain diabodies Protein Eng. 14 2001 815 823
    • (2001) Protein Eng. , vol.14 , pp. 815-823
    • Völkel, T.1
  • 45
    • 79955970356 scopus 로고    scopus 로고
    • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
    • P.A. Moore Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma Blood 117 2011 4542 4551
    • (2011) Blood , vol.117 , pp. 4542-4551
    • Moore, P.A.1
  • 46
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • D. Neri, and R. Bicknell Tumour vascular targeting Nat. Rev. Cancer 5 2005 436 446
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 47
    • 84861610591 scopus 로고    scopus 로고
    • Immunocytokines: A novel class of potent armed antibodies
    • N. Pasche, and D. Neri Immunocytokines: a novel class of potent armed antibodies Drug Discov. Today 17 2012 583 590
    • (2012) Drug Discov. Today , vol.17 , pp. 583-590
    • Pasche, N.1    Neri, D.2
  • 48
    • 84884828581 scopus 로고    scopus 로고
    • Immunocytokines: A review of molecules in clinical development for cancer therapy
    • T. List, and D. Neri Immunocytokines: a review of molecules in clinical development for cancer therapy Clin. Pharmacol. 20 2013 29 45
    • (2013) Clin. Pharmacol. , vol.20 , pp. 29-45
    • List, T.1    Neri, D.2
  • 49
    • 34547855838 scopus 로고    scopus 로고
    • Recombinant bispecific antibodies for cellular cancer immunotherapy
    • D. Müller, and R.E. Kontermann Recombinant bispecific antibodies for cellular cancer immunotherapy Curr. Opin. Mol. Ther. 9 2007 319 326
    • (2007) Curr. Opin. Mol. Ther. , vol.9 , pp. 319-326
    • Müller, D.1    Kontermann, R.E.2
  • 50
    • 84899744468 scopus 로고    scopus 로고
    • A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells
    • U. Reusch A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells MAbs 6 2014 728 739
    • (2014) MAbs , vol.6 , pp. 728-739
    • Reusch, U.1
  • 51
    • 0034662632 scopus 로고    scopus 로고
    • Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 × CD19 tandem diabody, and CD28 costimulation
    • B. Cochlovius Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 × CD19 tandem diabody, and CD28 costimulation Cancer Res. 60 2000 4336 4341
    • (2000) Cancer Res. , vol.60 , pp. 4336-4341
    • Cochlovius, B.1
  • 52
    • 0028302596 scopus 로고
    • Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli
    • M. Gruber Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli J. Immunol. 152 1994 5368 5374
    • (1994) J. Immunol. , vol.152 , pp. 5368-5374
    • Gruber, M.1
  • 53
    • 0029148633 scopus 로고
    • A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
    • M. Mack A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity Proc. Natl. Acad. Sci. U. S. A. 92 1995 7021 7025
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 7021-7025
    • MacK, M.1
  • 54
    • 26244466523 scopus 로고    scopus 로고
    • BiTEs: Bispecific antibody constructs with unique anti-tumor activity
    • E. Wolf BiTEs: bispecific antibody constructs with unique anti-tumor activity Drug Discov. Today 10 2005 1237 1244
    • (2005) Drug Discov. Today , vol.10 , pp. 1237-1244
    • Wolf, E.1
  • 55
    • 84878931351 scopus 로고    scopus 로고
    • Targeting T cells to tumor cells using bispecific antibodies
    • S.R. Frankel, and P.A. Baeuerle Targeting T cells to tumor cells using bispecific antibodies Curr. Opin. Chem. Biol. 17 2013 385 392
    • (2013) Curr. Opin. Chem. Biol. , vol.17 , pp. 385-392
    • Frankel, S.R.1    Baeuerle, P.A.2
  • 56
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • R. Bargou Tumor regression in cancer patients by very low doses of a T cell-engaging antibody Science 321 2008 974 977
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1
  • 57
    • 0034671309 scopus 로고    scopus 로고
    • Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: Improved biodistribution and potential for therapeutic application
    • A. Goel Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: improved biodistribution and potential for therapeutic application Cancer Res. 60 2000 6964 6971
    • (2000) Cancer Res. , vol.60 , pp. 6964-6971
    • Goel, A.1
  • 58
    • 0034740816 scopus 로고    scopus 로고
    • 99mTc-labeled divalent and tetravalent CC49 single-chain Fvs: Novel imaging agents for rapid in vivo localization of human colon carcinoma
    • 99mTc-labeled divalent and tetravalent CC49 single-chain Fvs: novel imaging agents for rapid in vivo localization of human colon carcinoma J. Nucl. Med. 42 2001 1519 1527
    • (2001) J. Nucl. Med. , vol.42 , pp. 1519-1527
    • Goel, A.1
  • 59
    • 0035831483 scopus 로고    scopus 로고
    • Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
    • K. Els Conrath Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs J. Biol. Chem. 276 2001 7346 7350
    • (2001) J. Biol. Chem. , vol.276 , pp. 7346-7350
    • Els Conrath, K.1
  • 60
    • 0347384086 scopus 로고    scopus 로고
    • Design of multivalent complexes using the barnase∗barstar module
    • S.M. Deyev Design of multivalent complexes using the barnase∗barstar module Nat. Biotechnol. 21 2003 1486 1492
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1486-1492
    • Deyev, S.M.1
  • 61
    • 84866518210 scopus 로고    scopus 로고
    • Heterodimeric barnase-barstar vaccine molecules: Influence of one versus two targeting units specific for antigen presenting cells
    • H.C. Spång Heterodimeric barnase-barstar vaccine molecules: influence of one versus two targeting units specific for antigen presenting cells PLOS ONE 7 2012 e45393
    • (2012) PLOS ONE , vol.7 , pp. e45393
    • Spång, H.C.1
  • 62
    • 0037731516 scopus 로고    scopus 로고
    • Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor-alpha
    • C. Halin Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor-alpha Cancer Res. 63 2003 3202 3210
    • (2003) Cancer Res. , vol.63 , pp. 3202-3210
    • Halin, C.1
  • 63
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNF-alpha to tumor blood vessels
    • L. Borsi Selective targeted delivery of TNF-alpha to tumor blood vessels Blood 102 2003 4384 4392
    • (2003) Blood , vol.102 , pp. 4384-4392
    • Borsi, L.1
  • 64
    • 33646407812 scopus 로고    scopus 로고
    • Targeted delivery of tumor necrosis factor-alpha to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin
    • E. Balza Targeted delivery of tumor necrosis factor-alpha to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin Clin. Cancer Res. 12 2006 2575 2582
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2575-2582
    • Balza, E.1
  • 65
    • 0028971209 scopus 로고
    • Single-chain antibody streptavidin fusions: Tetrameric bifunctional scFv-complexes with biotin binding activity and enhanced affinity to antigen
    • S.M. Kipriyanov Single-chain antibody streptavidin fusions: tetrameric bifunctional scFv-complexes with biotin binding activity and enhanced affinity to antigen Hum. Antibod. Hybrid. 6 1995 93 101
    • (1995) Hum. Antibod. Hybrid. , vol.6 , pp. 93-101
    • Kipriyanov, S.M.1
  • 66
    • 50249135564 scopus 로고    scopus 로고
    • Multivalency: The hallmark of antibodies used for optimization of tumor targeting by design
    • S.M. Deyev, and E.N. Lebedenko Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design Bioessays 30 2008 904 918
    • (2008) Bioessays , vol.30 , pp. 904-918
    • Deyev, S.M.1    Lebedenko, E.N.2
  • 67
    • 33745211940 scopus 로고    scopus 로고
    • Enhanced antiangiogenic therapy with antibody-collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events
    • V.J. Sánchez-Arévalo Lobo Enhanced antiangiogenic therapy with antibody-collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events Int. J. Cancer 119 2006 455 462
    • (2006) Int. J. Cancer , vol.119 , pp. 455-462
    • Sánchez-Arévalo Lobo, V.J.1
  • 68
    • 65549161350 scopus 로고    scopus 로고
    • In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences
    • A.M. Cuesta In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences PLoS ONE 4 2009 e5381
    • (2009) PLoS ONE , vol.4 , pp. e5381
    • Cuesta, A.M.1
  • 69
    • 84858262290 scopus 로고    scopus 로고
    • Improved stability of multivalent antibodies containing the human collagen XV trimerization domain
    • A.M. Cuesta Improved stability of multivalent antibodies containing the human collagen XV trimerization domain MAbs 4 2012 226 232
    • (2012) MAbs , vol.4 , pp. 226-232
    • Cuesta, A.M.1
  • 70
    • 79953156087 scopus 로고    scopus 로고
    • The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies
    • D. Sánchez-Martín The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies J. Biol. Chem. 286 2011 5197 5203
    • (2011) J. Biol. Chem. , vol.286 , pp. 5197-5203
    • Sánchez-Martín, D.1
  • 71
    • 84872854587 scopus 로고    scopus 로고
    • Generation and characterization of monospecific and bispecific hexavalent trimerbodies
    • A. Blanco-Toribio Generation and characterization of monospecific and bispecific hexavalent trimerbodies MAbs 5 2013 1 10
    • (2013) MAbs , vol.5 , pp. 1-10
    • Blanco-Toribio, A.1
  • 72
    • 55549103706 scopus 로고    scopus 로고
    • Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold
    • C.Y. Fan Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold FASEB J. 22 2008 3795 3804
    • (2008) FASEB J. , vol.22 , pp. 3795-3804
    • Fan, C.Y.1
  • 73
    • 33646477258 scopus 로고    scopus 로고
    • Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
    • E.A. Rossi Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting Proc. Natl. Acad. Sci. U. S. A. 103 2006 6841 6846
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 6841-6846
    • Rossi, E.A.1
  • 74
    • 67650346177 scopus 로고    scopus 로고
    • Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma
    • E.A. Rossi Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma Blood 113 2009 6161 6171
    • (2009) Blood , vol.113 , pp. 6161-6171
    • Rossi, E.A.1
  • 75
    • 85047686965 scopus 로고    scopus 로고
    • A new class of bispecific antibodies to redirect T cells for cancer immunotherapy
    • D.L. Rossi A new class of bispecific antibodies to redirect T cells for cancer immunotherapy MAbs 6 2014 381 391
    • (2014) MAbs , vol.6 , pp. 381-391
    • Rossi, D.L.1
  • 76
    • 0344255688 scopus 로고    scopus 로고
    • Pentamerization of single-domain antibodies from phage libraries: A novel strategy for the rapid generation of high-avidity antibody reagents
    • J. Zhang Pentamerization of single-domain antibodies from phage libraries: a novel strategy for the rapid generation of high-avidity antibody reagents J. Mol. Biol. 335 2004 49 56
    • (2004) J. Mol. Biol. , vol.335 , pp. 49-56
    • Zhang, J.1
  • 77
    • 33845886914 scopus 로고    scopus 로고
    • The assembly of single domain antibodies into bispecific decavalent molecules
    • E. Stone The assembly of single domain antibodies into bispecific decavalent molecules J. Immunol. Methods 318 2007 88 94
    • (2007) J. Immunol. Methods , vol.318 , pp. 88-94
    • Stone, E.1
  • 78
    • 0026528230 scopus 로고
    • Miniantibodies: Use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli
    • P. Pack, and A. Pluckthun Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli Biochemistry 31 1992 1579 1584
    • (1992) Biochemistry , vol.31 , pp. 1579-1584
    • Pack, P.1    Pluckthun, A.2
  • 79
    • 0034671764 scopus 로고    scopus 로고
    • Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives
    • R. Schoonjans Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives J. Immunol. 165 2000 7050 7057
    • (2000) J. Immunol. , vol.165 , pp. 7050-7057
    • Schoonjans, R.1
  • 80
    • 0035043050 scopus 로고    scopus 로고
    • A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain
    • R. Schoonjans A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain Biomol. Eng. 17 2001 193 202
    • (2001) Biomol. Eng. , vol.17 , pp. 193-202
    • Schoonjans, R.1
  • 81
    • 0142061073 scopus 로고    scopus 로고
    • Di-diabody: A novel tetravalent bispecific antibody molecule by design
    • D. Lu Di-diabody: a novel tetravalent bispecific antibody molecule by design J. Immunol. Methods 279 2003 219 232
    • (2003) J. Immunol. Methods , vol.279 , pp. 219-232
    • Lu, D.1
  • 82
    • 0028949091 scopus 로고
    • Tetravalent miniantibodies with high avidity assembling in Escherichia coli
    • P. Pack Tetravalent miniantibodies with high avidity assembling in Escherichia coli J. Mol. Biol. 246 1995 28 34
    • (1995) J. Mol. Biol. , vol.246 , pp. 28-34
    • Pack, P.1


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