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Volumn 26, Issue 6, 2005, Pages 641-648

Antibody engineering: Facing new challenges in cancer therapy

Author keywords

Antibody formation; Biomedical engineering; Gene therapy; Immunoglobulin fragments; Monoclonal antibodies; Recombinant proteins

Indexed keywords

ADENOVIRUS VECTOR; ANTIBODY CONJUGATE; BISPECIFIC ANTIBODY; CALICHEAMICIN; CHIMERIC IMMUNE RECEPTOR; CHIMERIC PROTEIN; CYTOKINE; DIPHTHERIA TOXIN; DRUG; GEMTUZUMAB OZOGAMICIN; IBRITUMOMAB TIUXETAN; IMMUNOCYTOKINE; IMMUNOGLOBULIN FRAGMENT; INTRACELLULAR ANTIBODY; IODINE 131; MAYTANSINE; MONOCLONAL ANTIBODY; PRODRUG; RADIOISOTOPE; RECEPTOR; RECOMBINANT ANTIBODY; RETROVIRUS VECTOR; RICIN; TOSITUMOMAB; TOXIN; UNCLASSIFIED DRUG; YTTRIUM 90;

EID: 20444365508     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00135.x     Document Type: Review
Times cited : (54)

References (50)
  • 1
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495-7.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 2
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001; 1: 118-29.
    • (2001) Nat Rev Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 3
    • 0037235949 scopus 로고    scopus 로고
    • Engineered antibodies
    • Hudson PJ, Souriau C. Engineered antibodies. Nat Med 2003; 9: 129-34.
    • (2003) Nat Med , vol.9 , pp. 129-134
    • Hudson, P.J.1    Souriau, C.2
  • 4
    • 0037264969 scopus 로고    scopus 로고
    • Therapeutic antibodies for human diseases at the dawn of the twenty-first century
    • Brekke OH, Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat Rev Drug Disc 2003; 2: 52-62.
    • (2003) Nat Rev Drug Disc , vol.2 , pp. 52-62
    • Brekke, O.H.1    Sandlie, I.2
  • 5
    • 0035794194 scopus 로고    scopus 로고
    • High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R
    • Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, et al. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 2001; 276: 6591-604.
    • (2001) J Biol Chem , vol.276 , pp. 6591-6604
    • Shields, R.L.1    Namenuk, A.K.2    Hong, K.3    Meng, Y.G.4    Rae, J.5    Briggs, J.6
  • 7
    • 0033044588 scopus 로고    scopus 로고
    • Engineered glycoforms of an antineuro-blastoma IgG 1 with optimized antibody-dependent cellular cytotoxic activity
    • Umaña P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE. Engineered glycoforms of an antineuro-blastoma IgG 1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol 1999; 17: 176-80.
    • (1999) Nat Biotechnol , vol.17 , pp. 176-180
    • Umaña, P.1    Jean-Mairet, J.2    Moudry, R.3    Amstutz, H.4    Bailey, J.E.5
  • 8
    • 0030796064 scopus 로고    scopus 로고
    • Increasing the serum persistence of an IgG fragment by random mutagenesis
    • Ghetie V, Popov S, Borvak J, Radu C, Matesoi D, Medesan C, et al. Increasing the serum persistence of an IgG fragment by random mutagenesis. Nat Biotechnol 1997; 15: 637-40.
    • (1997) Nat Biotechnol , vol.15 , pp. 637-640
    • Ghetie, V.1    Popov, S.2    Borvak, J.3    Radu, C.4    Matesoi, D.5    Medesan, C.6
  • 9
    • 0027008593 scopus 로고
    • Mono- and bivalent antibody fragments produced in Escherichia coli: Engineering, folding and antigen binding
    • Pluckthun A. Mono- and bivalent antibody fragments produced in Escherichia coli: engineering, folding and antigen binding. Immunol Rev 1992; 130: 151-88.
    • (1992) Immunol Rev , vol.130 , pp. 151-188
    • Pluckthun, A.1
  • 10
    • 0027197493 scopus 로고
    • "Diabodies": Small bivalent and bispecific antibody fragments
    • Holliger P, Prospero T, Winter G. "Diabodies": small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993; 90: 6444-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 11
    • 11844273237 scopus 로고    scopus 로고
    • Recombinant bispecific antibodies for cancer therapy
    • Kontermann RE. Recombinant bispecific antibodies for cancer therapy. Acta Pharmacol Sin 2005; 26: 1-9.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1-9
    • Kontermann, R.E.1
  • 12
    • 12344336363 scopus 로고    scopus 로고
    • Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals
    • Natarajan A, Xiong CY, Albrecht H, DeNardo GL, DeNardo SJ. Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals. Bioconjug Chem 2005; 16: 113-21.
    • (2005) Bioconjug Chem , vol.16 , pp. 113-121
    • Natarajan, A.1    Xiong, C.Y.2    Albrecht, H.3    Denardo, G.L.4    Denardo, S.J.5
  • 14
    • 0037615120 scopus 로고    scopus 로고
    • Advancing role of radiolabeled antibodies in the therapy of cancer
    • Goldenberg DM. Advancing role of radiolabeled antibodies in the therapy of cancer. Cancer Immunol Immunother 2003; 52: 281-96.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 281-296
    • Goldenberg, D.M.1
  • 15
    • 0035181464 scopus 로고    scopus 로고
    • Strategies for enzyme/prodrug cancer therapy
    • Xu G, McLeod HL. Strategies for enzyme/prodrug cancer therapy. Clin Cancer Res 2001; 7: 3314-24.
    • (2001) Clin Cancer Res , vol.7 , pp. 3314-3324
    • Xu, G.1    McLeod, H.L.2
  • 16
    • 19944427731 scopus 로고    scopus 로고
    • Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy
    • Sharma SK, Pedley RB, Bhatia J, Boxer GM, El-Emir E, Qureshi U, et al. Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy. Clin Cancer Res 2005; 11: 814-25.
    • (2005) Clin Cancer Res , vol.11 , pp. 814-825
    • Sharma, S.K.1    Pedley, R.B.2    Bhatia, J.3    Boxer, G.M.4    El-Emir, E.5    Qureshi, U.6
  • 17
    • 0035912801 scopus 로고    scopus 로고
    • In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy
    • Shabat D, Lode HN, Pertl U, Reisfeld RA, Rader C, Lerner RA, et al. In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy. Proc Natl Acad Sci USA 2001; 98: 7528-33.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7528-7533
    • Shabat, D.1    Lode, H.N.2    Pertl, U.3    Reisfeld, R.A.4    Rader, C.5    Lerner, R.A.6
  • 19
    • 17844365091 scopus 로고    scopus 로고
    • Simultaneous targeting of IL2 and IL12 to Hodgkin's lymphoma cells enhances activation of resting NK cells and tumor cell lysis
    • Hombach A, Heuser C, Abken H. Simultaneous targeting of IL2 and IL12 to Hodgkin's lymphoma cells enhances activation of resting NK cells and tumor cell lysis. Int J Cancer. 2005; 115: 241-7.
    • (2005) Int J Cancer , vol.115 , pp. 241-247
    • Hombach, A.1    Heuser, C.2    Abken, H.3
  • 20
    • 18544371520 scopus 로고    scopus 로고
    • An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma
    • Gillies SD, Lan Y, Williams S, Carr F, Forman S, Raubitschek A, et al. An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma. Blood. 2005; 105: 3972-8.
    • (2005) Blood , vol.105 , pp. 3972-3978
    • Gillies, S.D.1    Lan, Y.2    Williams, S.3    Carr, F.4    Forman, S.5    Raubitschek, A.6
  • 21
    • 0036194917 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
    • Halin C, Rondini S, Nilsson F, Berndt A, Kosmehl H, Zardi L, et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 2002; 20: 264-9.
    • (2002) Nat Biotechnol , vol.20 , pp. 264-269
    • Halin, C.1    Rondini, S.2    Nilsson, F.3    Berndt, A.4    Kosmehl, H.5    Zardi, L.6
  • 22
    • 0842303168 scopus 로고    scopus 로고
    • Antibodies and gene therapy: Teaching old 'magic bullets' new tricks
    • Sanz L, Blanco B, Alvarez-Vallina L. Antibodies and gene therapy: teaching old 'magic bullets' new tricks. Trends Immunol 2004; 25: 85-91.
    • (2004) Trends Immunol , vol.25 , pp. 85-91
    • Sanz, L.1    Blanco, B.2    Alvarez-Vallina, L.3
  • 24
    • 0036196127 scopus 로고    scopus 로고
    • Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv
    • Arafat WO, Gomez-Navarro J, Buchsbau DJ, Xiang J, Wang M, Casado, et al. Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv. Gene Ther 2002; 9: 256-62.
    • (2002) Gene Ther , vol.9 , pp. 256-262
    • Arafat, W.O.1    Gomez-Navarro, J.2    Buchsbau, D.J.3    Xiang, J.4    Wang, M.5    Casado6
  • 25
    • 0035667982 scopus 로고    scopus 로고
    • Generation and characterization of recombinant human antibodies specific for native laminin epitopes: Potential application in cancer therapy
    • Sanz L, Kristensen P, Russell SJ, Ramirez Garcia JR, Alvarez-Vallina L. Generation and characterization of recombinant human antibodies specific for native laminin epitopes: potential application in cancer therapy. Cancer Immunol Immunother 2001; 50: 557-65.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 557-565
    • Sanz, L.1    Kristensen, P.2    Russell, S.J.3    Ramirez Garcia, J.R.4    Alvarez-Vallina, L.5
  • 26
    • 0345146927 scopus 로고    scopus 로고
    • A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis
    • Sanz L, Garcia-Bermejo L, Blanco FJ, Kristensen P, Feijoo M, Suarez E, et al. A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis. EMBO J 2003; 22: 1508-17.
    • (2003) EMBO J , vol.22 , pp. 1508-1517
    • Sanz, L.1    Garcia-Bermejo, L.2    Blanco, F.J.3    Kristensen, P.4    Feijoo, M.5    Suarez, E.6
  • 27
    • 0036053161 scopus 로고    scopus 로고
    • Single-chain antibody-based gene therapy: Inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices
    • Sanz L, Kristensen P, Blanco B, Facteau S, Russell SJ, Winter G, et al. Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices. Gene Ther 2002; 9: 1049-53.
    • (2002) Gene Ther , vol.9 , pp. 1049-1053
    • Sanz, L.1    Kristensen, P.2    Blanco, B.3    Facteau, S.4    Russell, S.J.5    Winter, G.6
  • 28
    • 0038108811 scopus 로고    scopus 로고
    • Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells
    • Blanco B, Holliger P, Vile R, Alvarez-Vallina L. Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells. J Immunol 2003; 171: 1070-7.
    • (2003) J Immunol , vol.171 , pp. 1070-1077
    • Blanco, B.1    Holliger, P.2    Vile, R.3    Alvarez-Vallina, L.4
  • 29
    • 4744376594 scopus 로고    scopus 로고
    • Targeting of tumor cells by lymphocytes engineered to express, chimeric receptor genes
    • Baxenavis CN, Papamichail M. Targeting of tumor cells by lymphocytes engineered to express, chimeric receptor genes. Cancer Immunol Immunother 2004; 53: 893-903.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 893-903
    • Baxenavis, C.N.1    Papamichail, M.2
  • 30
    • 0035502545 scopus 로고    scopus 로고
    • Genetic approaches for antigen-selective cell therapy
    • Álvarez-Vallina L. Genetic approaches for antigen-selective cell therapy. Curr Gene Ther 2001; 4: 385-97.
    • (2001) Curr Gene Ther , vol.4 , pp. 385-397
    • Álvarez-Vallina, L.1
  • 31
    • 0037348324 scopus 로고    scopus 로고
    • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
    • Brentjens RJ, Latouche JB, Santos E, Marti F, Gong MC, Lyddane C et al. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 2003; 9: 279-86.
    • (2003) Nat Med , vol.9 , pp. 279-286
    • Brentjens, R.J.1    Latouche, J.B.2    Santos, E.3    Marti, F.4    Gong, M.C.5    Lyddane, C.6
  • 32
    • 0037103311 scopus 로고    scopus 로고
    • Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction
    • Uherek C, Tonn T, Uherek B, Becker S, Schnierle B, Klingemann HG, et al. Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction. Blood 2002; 100: 1265-73.
    • (2002) Blood , vol.100 , pp. 1265-1273
    • Uherek, C.1    Tonn, T.2    Uherek, B.3    Becker, S.4    Schnierle, B.5    Klingemann, H.G.6
  • 33
    • 0029841565 scopus 로고    scopus 로고
    • Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors
    • Alvarez-Vallina L, Hawkins RE. Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur J Immunol 1996; 26: 2304-9.
    • (1996) Eur J Immunol , vol.26 , pp. 2304-2309
    • Alvarez-Vallina, L.1    Hawkins, R.E.2
  • 34
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 1998; 161: 2791-7.
    • (1998) J Immunol , vol.161 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3    Weir, A.N.4
  • 35
    • 13844272633 scopus 로고    scopus 로고
    • Antibody engineering, virus retargeting and cellular immunotherapy: One ring to rule them all?
    • Sanz L, Qiao J, Vile R, Alvarez-Vallina L. Antibody engineering, virus retargeting and cellular immunotherapy: one ring to rule them all? Curr Gene Ther 2005; 5: 63-70.
    • (2005) Curr Gene Ther , vol.5 , pp. 63-70
    • Sanz, L.1    Qiao, J.2    Vile, R.3    Alvarez-Vallina, L.4
  • 37
    • 0037303641 scopus 로고    scopus 로고
    • Antibody-mediated targeting of an adenovirus vector modified to contain a synthetic immunoglobulin g-binding domain in the capsid
    • Volpers C, Thirion C, Biermann V, Hussmann S, Kewes H, Dunant P, et al. Antibody-mediated targeting of an adenovirus vector modified to contain a synthetic immunoglobulin g-binding domain in the capsid. J Virol 2003; 77: 2093-104.
    • (2003) J Virol , vol.77 , pp. 2093-2104
    • Volpers, C.1    Thirion, C.2    Biermann, V.3    Hussmann, S.4    Kewes, H.5    Dunant, P.6
  • 38
    • 0027172622 scopus 로고
    • Retroviral vectors displaying functional antibody fragments
    • Russell SJ, Hawkins RE, Winter G. Retroviral vectors displaying functional antibody fragments. Nucleic Acids Res 1993; 21: 1081-5.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1081-1085
    • Russell, S.J.1    Hawkins, R.E.2    Winter, G.3
  • 39
    • 0029145999 scopus 로고
    • Generation of targeted retroviral vectors by using single-chain variable fragment: An approach to in vivo gene delivery
    • Somia NV, Zoppe M, Verma IM. Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery. Proc Natl Acad Sci USA 1995; 92: 7570-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7570-7574
    • Somia, N.V.1    Zoppe, M.2    Verma, I.M.3
  • 40
    • 0031060146 scopus 로고    scopus 로고
    • Toward highly efficient cell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies
    • Chu TH, Dornburg R. Toward highly efficient cell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies. J Virol 1997; 71: 720-5.
    • (1997) J Virol , vol.71 , pp. 720-725
    • Chu, T.H.1    Dornburg, R.2
  • 42
    • 16244394824 scopus 로고    scopus 로고
    • Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection
    • Morizono K, Xie Y, Ringpis GE, Johnson M, Nassanian H, Lee B, et al. Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med 2005; 11: 346-52.
    • (2005) Nat Med , vol.11 , pp. 346-352
    • Morizono, K.1    Xie, Y.2    Ringpis, G.E.3    Johnson, M.4    Nassanian, H.5    Lee, B.6
  • 43
    • 0035121424 scopus 로고    scopus 로고
    • Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen
    • Hammond AL, Plemper RK, Zhang J, Schneider U, Russell SJ, Cattaneo R. Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen. J Virol 2001; 75: 2087-96.
    • (2001) J Virol , vol.75 , pp. 2087-2096
    • Hammond, A.L.1    Plemper, R.K.2    Zhang, J.3    Schneider, U.4    Russell, S.J.5    Cattaneo, R.6
  • 45
    • 0037769825 scopus 로고    scopus 로고
    • Oncolytic measles viruses displaying a single-chain antibody against CD38, a myeloma cell marker
    • Peng KW, Donovan KA, Schneider U, Cattaneo R, Lust JA, Russell SJ. Oncolytic measles viruses displaying a single-chain antibody against CD38, a myeloma cell marker. Blood 2003; 101: 2557-62.
    • (2003) Blood , vol.101 , pp. 2557-2562
    • Peng, K.W.1    Donovan, K.A.2    Schneider, U.3    Cattaneo, R.4    Lust, J.A.5    Russell, S.J.6
  • 46
    • 0141681221 scopus 로고    scopus 로고
    • Intracellular antibodies and challenges facing their use as therapeutic agents
    • Lobato MN, Rabbits TH. Intracellular antibodies and challenges facing their use as therapeutic agents. Trends Mol Med 2003; 9: 390-6.
    • (2003) Trends Mol Med , vol.9 , pp. 390-396
    • Lobato, M.N.1    Rabbits, T.H.2
  • 47
    • 7944230671 scopus 로고    scopus 로고
    • Intrabodies: Production and promise
    • Stocks MR. Intrabodies: production and promise. Drug Discov Today 2004; 9: 960-6.
    • (2004) Drug Discov Today , vol.9 , pp. 960-966
    • Stocks, M.R.1
  • 48
    • 0346220285 scopus 로고    scopus 로고
    • Intra-diabodies: Bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors
    • Jendreyko N, Popkov M, Beerli RR, Chung J, McGavern DB, Rader C et al. Intra-diabodies: bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. J Biol Chem 2003; 278: 47812-9.
    • (2003) J Biol Chem , vol.278 , pp. 47812-47819
    • Jendreyko, N.1    Popkov, M.2    Beerli, R.R.3    Chung, J.4    McGavern, D.B.5    Rader, C.6
  • 49
    • 1642535587 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment
    • Rousselet N, Mills L, Jean D, Tellez C, Bar-Eli M, Frade R. Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment. Cancer Res 2004; 64: 146-51.
    • (2004) Cancer Res , vol.64 , pp. 146-151
    • Rousselet, N.1    Mills, L.2    Jean, D.3    Tellez, C.4    Bar-Eli, M.5    Frade, R.6
  • 50


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