The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity

Protein Engineering, Design and Selection

Volumn 25, Issue 10, 2012, Pages 603-612

  Seifert, Oliver ^a   Plappert, Aline ^a   Heidel, Nadine ^a   Fellermeier, Sina ^a   Messerschmidt, Sylvia K E ^a   Richter, Fabian ^a   Kontermann, Roland E ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

bifunctional fusion protein; bispecific fusion protein; dual targeting; homodimerization; tumor necrosis factor

Indexed keywords

ANTI-EGFR; ANTIBODY FRAGMENT; BIFUNCTIONAL; C-TERMINUS; CELL KILLING; DIABODY; DUAL TARGETING; EPIDERMAL GROWTH FACTOR RECEPTORS; EPITHELIAL CELL ADHESION MOLECULES; FUSION PROTEINS; HEAVY CHAIN; HOMODIMERIZATION; HUMAN EPIDERMAL GROWTH FACTOR; MEMBRANE-BOUND; THERAPEUTIC MOLECULES; TUMOR CELLS; TUMOR NECROSIS FACTORS;

DIMERIZATION; GLYCOPROTEINS; MACROPHAGES; MOLECULES; PROTEINS;

CYTOLOGY;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPITHELIAL CELL ADHESION MOLECULE; HYBRID PROTEIN; IMMUNOGLOBULIN MU CHAIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; BISPECIFIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2 PROTEIN, HUMAN; IMMUNOGLOBULIN M;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL KILLING; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DUAL SPECIFICITY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; TUMOR CELL; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANTIBODIES, BISPECIFIC; HUMANS; IMMUNOGLOBULIN M; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES;

EID: 84867000911     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs059     Document Type: Article

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