-
1
-
-
84873124622
-
Advances in the development of cancer immunotherapies
-
Gao J., Bernatchez C., Sharma P., Radvanyi L.G., Hwu P. Advances in the development of cancer immunotherapies. Trends Immunol 2013, 34:90-98.
-
(2013)
Trends Immunol
, vol.34
, pp. 90-98
-
-
Gao, J.1
Bernatchez, C.2
Sharma, P.3
Radvanyi, L.G.4
Hwu, P.5
-
2
-
-
84858800620
-
The immune contexture in human tumours: impact on clinical outcome
-
Fridman W.H., Pagès F., Sautès-Fridman C., Galon J The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012, 12:298-306.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 298-306
-
-
Fridman, W.H.1
Pagès, F.2
Sautès-Fridman, C.3
Galon, J.4
-
3
-
-
84860220430
-
Tumor-dependent down-regulation of the ζ-chain in T-cells is detectable in early breast cancer and correlates with immune cell function
-
Boniface J.D., Poschke I., Mao Y., Kiessling R. Tumor-dependent down-regulation of the ζ-chain in T-cells is detectable in early breast cancer and correlates with immune cell function. Int J Cancer 2012, 131:129-139.
-
(2012)
Int J Cancer
, vol.131
, pp. 129-139
-
-
Boniface, J.D.1
Poschke, I.2
Mao, Y.3
Kiessling, R.4
-
4
-
-
79952281795
-
Improving cancer immunotherapy by targeting tumor-induced immune suppression
-
Stewart T., Smyth M. Improving cancer immunotherapy by targeting tumor-induced immune suppression. Cancer Metast Rev 2011, 30:125-140.
-
(2011)
Cancer Metast Rev
, vol.30
, pp. 125-140
-
-
Stewart, T.1
Smyth, M.2
-
5
-
-
84862135169
-
What are regulatory T cells (Treg) regulating in cancer and why?
-
Whiteside T.L. What are regulatory T cells (Treg) regulating in cancer and why?. Semin Cancer Biol 2012, 22:327-334.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 327-334
-
-
Whiteside, T.L.1
-
6
-
-
84869380716
-
Immunology beats cancer: a blueprint for successful translation
-
Pardoll D.M. Immunology beats cancer: a blueprint for successful translation. Nat Immunol 2012, 13:1129-1132.
-
(2012)
Nat Immunol
, vol.13
, pp. 1129-1132
-
-
Pardoll, D.M.1
-
7
-
-
84872668649
-
Bispecific T cell engager for cancer therapy
-
Springer-Verlag, R.E. Kontermann (Ed.)
-
Baeuerle P.A., Zugmaier G., Ruttinger D. Bispecific T cell engager for cancer therapy. Bispecific Antibodies 2011, 273-287. Springer-Verlag. R.E. Kontermann (Ed.).
-
(2011)
Bispecific Antibodies
, pp. 273-287
-
-
Baeuerle, P.A.1
Zugmaier, G.2
Ruttinger, D.3
-
8
-
-
84862251353
-
Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on
-
Riethmuller G. Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on. Cancer Immun 2012, 12:12.
-
(2012)
Cancer Immun
, vol.12
, pp. 12
-
-
Riethmuller, G.1
-
9
-
-
84867858547
-
Blinatumomab: a historical perspective
-
Nagorsen D., Kufer P., Baeuerle P.A., Bargou R. Blinatumomab: a historical perspective. Pharmacol Ther 2012, 136:334-342.
-
(2012)
Pharmacol Ther
, vol.136
, pp. 334-342
-
-
Nagorsen, D.1
Kufer, P.2
Baeuerle, P.A.3
Bargou, R.4
-
10
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou R., Leo E., Zugmaier G., Klinger M., Goebeler M., Knop S., Noppeney R., Viardot A., Hess G., Schuler M., et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008, 321:974-977.
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
Klinger, M.4
Goebeler, M.5
Knop, S.6
Noppeney, R.7
Viardot, A.8
Hess, G.9
Schuler, M.10
-
11
-
-
84867857964
-
Blinatumomab monotherapy shows efficacy in patients with relapsed diffuse large B cell lymphoma
-
Viardot A., Goebeler M., Noppeney R., Krause S.W., Kallert S., Ferstl B., Mackensen A., Rupertus K., Soekler M., Kanz L., et al. Blinatumomab monotherapy shows efficacy in patients with relapsed diffuse large B cell lymphoma. Blood 2011, 118:711-712.
-
(2011)
Blood
, vol.118
, pp. 711-712
-
-
Viardot, A.1
Goebeler, M.2
Noppeney, R.3
Krause, S.W.4
Kallert, S.5
Ferstl, B.6
Mackensen, A.7
Rupertus, K.8
Soekler, M.9
Kanz, L.10
-
12
-
-
84873077857
-
2/d is tolerable and highly effective
-
2/d is tolerable and highly effective. ASH Annu Meet Abst 2010, 116:2880.
-
(2010)
ASH Annu Meet Abst
, vol.116
, pp. 2880
-
-
Viardot, A.1
Goebeler, M.2
Scheele, J.S.3
Zugmaier, G.4
Noppeney, R.5
Knop, S.6
Topp, M.S.7
Nagorsen, D.8
Klinger, M.9
Schmidt, M.10
-
13
-
-
84862634261
-
Blinatumomab (CD3/CD19 BITE antibody) results in a high response rate in patients with relapsed non-Hodgkin lymphoma (NHL) including MCL and DLBCL
-
(abstract 068)
-
Goebeler M., Viardot A., Noppeney R., Krause S., Mackensen A., Rupertus K., Kanz L., Knop S., Topp M., Scheele J., et al. Blinatumomab (CD3/CD19 BITE antibody) results in a high response rate in patients with relapsed non-Hodgkin lymphoma (NHL) including MCL and DLBCL. Ann Oncol (ICML) 2011, 22:105. (abstract 068).
-
(2011)
Ann Oncol (ICML)
, vol.22
, pp. 105
-
-
Goebeler, M.1
Viardot, A.2
Noppeney, R.3
Krause, S.4
Mackensen, A.5
Rupertus, K.6
Kanz, L.7
Knop, S.8
Topp, M.9
Scheele, J.10
-
14
-
-
84871491706
-
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
-
Topp M.S., Gökbuget N., Zugmaier G., Degenhard E., Goebeler M.-E., Klinger M., Neumann S.A., Horst H.A., Raff T., Viardot A., et al. Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 2012, 120:5185-5187.
-
(2012)
Blood
, vol.120
, pp. 5185-5187
-
-
Topp, M.S.1
Gökbuget, N.2
Zugmaier, G.3
Degenhard, E.4
Goebeler, M.-E.5
Klinger, M.6
Neumann, S.A.7
Horst, H.A.8
Raff, T.9
Viardot, A.10
-
15
-
-
79959312575
-
Targeted therapy with the T-Cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp M.S., Kufer P., Gökbuget N., Goebeler M., Klinger M., Neumann S., Horst H.-A., Raff T., Viardot A., Schmid M., et al. Targeted therapy with the T-Cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011, 29:2493-2498.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2493-2498
-
-
Topp, M.S.1
Kufer, P.2
Gökbuget, N.3
Goebeler, M.4
Klinger, M.5
Neumann, S.6
Horst, H.-A.7
Raff, T.8
Viardot, A.9
Schmid, M.10
-
16
-
-
84876272598
-
Anti-CD19 BiTE blinatumomab induces high complete remission rate and prolongs overall survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL)
-
Topp M.S., Goekbuget N., Zugmaier G., Viardot A., Stelljes M., Neumann S., Horst H.A., Reichle A., Marks R., Faul C., et al. Anti-CD19 BiTE blinatumomab induces high complete remission rate and prolongs overall survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). ASH Annu Meet Abst 2012, 120:670.
-
(2012)
ASH Annu Meet Abst
, vol.120
, pp. 670
-
-
Topp, M.S.1
Goekbuget, N.2
Zugmaier, G.3
Viardot, A.4
Stelljes, M.5
Neumann, S.6
Horst, H.A.7
Reichle, A.8
Marks, R.9
Faul, C.10
-
17
-
-
84863522243
-
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
-
Klinger M., Brandl C., Zugmaier G., Hijazi Y., Bargou R.C., Topp M.S., Gokbuget N., Neumann S., Goebeler M., Viardot A., et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 2012, 119:6226-6233.
-
(2012)
Blood
, vol.119
, pp. 6226-6233
-
-
Klinger, M.1
Brandl, C.2
Zugmaier, G.3
Hijazi, Y.4
Bargou, R.C.5
Topp, M.S.6
Gokbuget, N.7
Neumann, S.8
Goebeler, M.9
Viardot, A.10
-
18
-
-
84855952224
-
Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
-
Patriarca C., Macchi R.M., Marschner A.K., Mellstedt H. Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev 2012, 38:68-75.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 68-75
-
-
Patriarca, C.1
Macchi, R.M.2
Marschner, A.K.3
Mellstedt, H.4
-
19
-
-
39149130004
-
Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3
-
Amann M., Brischwein K., Lutterbuese P., Parr L., Petersen L., Lorenczewski G., Krinner E., Bruckmeier S., Lippold S., Kischel R., et al. Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3. Cancer Res 2008, 68:143-151.
-
(2008)
Cancer Res
, vol.68
, pp. 143-151
-
-
Amann, M.1
Brischwein, K.2
Lutterbuese, P.3
Parr, L.4
Petersen, L.5
Lorenczewski, G.6
Krinner, E.7
Bruckmeier, S.8
Lippold, S.9
Kischel, R.10
-
20
-
-
77954676136
-
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial
-
Heiss M.M., Murawa P., Koralewski P., Kutarska E., Kolesnik O.O., Ivanchenko V.V., Dudnichenko A.S., Aleknaviciene B., Razbadauskas A., Gore M., et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial. Int J Cancer 2010, 127:2209-2221.
-
(2010)
Int J Cancer
, vol.127
, pp. 2209-2221
-
-
Heiss, M.M.1
Murawa, P.2
Koralewski, P.3
Kutarska, E.4
Kolesnik, O.O.5
Ivanchenko, V.V.6
Dudnichenko, A.S.7
Aleknaviciene, B.8
Razbadauskas, A.9
Gore, M.10
-
21
-
-
64649103924
-
Mode of cytotoxic action of T cell-engaging BiTE antibody MT110
-
Haas C., Krinner E., Brischwein K., Hoffmann P., Lutterbuse R., Schlereth B., Kufer P., Baeuerle P.A. Mode of cytotoxic action of T cell-engaging BiTE antibody MT110. Immunobiology 2009, 214:441-453.
-
(2009)
Immunobiology
, vol.214
, pp. 441-453
-
-
Haas, C.1
Krinner, E.2
Brischwein, K.3
Hoffmann, P.4
Lutterbuse, R.5
Schlereth, B.6
Kufer, P.7
Baeuerle, P.A.8
-
22
-
-
84856007019
-
EpCAM/CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells
-
Cioffi M., Dorado J., Baeuerle P.A., Heeschen C. EpCAM/CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res 2012, 18:465-474.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 465-474
-
-
Cioffi, M.1
Dorado, J.2
Baeuerle, P.A.3
Heeschen, C.4
-
23
-
-
78149460436
-
Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells
-
Herrmann I., Baeuerle P.A., Friedrich M., Murr A., Filusch S., Ruttinger D., Majdoub M.W., Sharma S., Kufer P., Raum T., et al. Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells. PLoS ONE 2010, 5:e13474.
-
(2010)
PLoS ONE
, vol.5
-
-
Herrmann, I.1
Baeuerle, P.A.2
Friedrich, M.3
Murr, A.4
Filusch, S.5
Ruttinger, D.6
Majdoub, M.W.7
Sharma, S.8
Kufer, P.9
Raum, T.10
-
24
-
-
67651165121
-
Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release
-
Amann M., D'Argouges S., Lorenczewski G., Brischwein K., Kischel R., Lutterbuese R., Mangold S., Rau D., Volkland J., Pflanz S., et al. Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release. J Immunother 2009, 32:452-464.
-
(2009)
J Immunother
, vol.32
, pp. 452-464
-
-
Amann, M.1
D'Argouges, S.2
Lorenczewski, G.3
Brischwein, K.4
Kischel, R.5
Lutterbuese, R.6
Mangold, S.7
Rau, D.8
Volkland, J.9
Pflanz, S.10
-
25
-
-
54849440117
-
Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans
-
Amann M., Friedrich M., Lutterbuese P., Vieser E., Lorenczewski G., Petersen L., Brischwein K., Kufer P., Kischel R., Baeuerle P.A., et al. Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans. Cancer Immunol Immunother 2009, 58:95-109.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 95-109
-
-
Amann, M.1
Friedrich, M.2
Lutterbuese, P.3
Vieser, E.4
Lorenczewski, G.5
Petersen, L.6
Brischwein, K.7
Kufer, P.8
Kischel, R.9
Baeuerle, P.A.10
-
26
-
-
84867733430
-
A phase I study of EpCAM/CD3-bispecific antibody (MT110) in patients with advanced solid tumors
-
abstr 2504, 2012 ASCO Annual Meeting Proceeding
-
Fiedler W.M.W.M., Kebenko M., Goebeler M.-E., Ritter B., Quaas A., Vieser E., Hijazi Y., Patzak I., Friedrich M., Kufer P., Frankel S., Seggewiss-Bernhardt R., Kaubitzsch S. A phase I study of EpCAM/CD3-bispecific antibody (MT110) in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts) 2012, 30(suppl; abstr 2504). 2012 ASCO Annual Meeting Proceeding.
-
(2012)
J Clin Oncol (Meeting Abstracts)
, vol.30
, Issue.SUPPL.
-
-
Fiedler, W.M.W.M.1
Kebenko, M.2
Goebeler, M.-E.3
Ritter, B.4
Quaas, A.5
Vieser, E.6
Hijazi, Y.7
Patzak, I.8
Friedrich, M.9
Kufer, P.10
Frankel, S.11
Seggewiss-Bernhardt, R.12
Kaubitzsch, S.13
-
27
-
-
84878905117
-
Phase I safety and pharmacology study of the EpCAM/CD3-bispecific BiTE antibody MT110 in patients with metastatic colorectal, gastric, or lung cancer
-
15s (suppl; abstr 2573)
-
Fiedler W.M., Ritter B., Seggewiss R., Bokemeyer C., Fettes P., Klinger M., Vieser E., Ruettinger D., Kaubitzsch S., Wolf M. Phase I safety and pharmacology study of the EpCAM/CD3-bispecific BiTE antibody MT110 in patients with metastatic colorectal, gastric, or lung cancer. J Clin Oncol (Meeting Abstracts) 2010, 28(15s (suppl; abstr 2573)).
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
-
-
Fiedler, W.M.1
Ritter, B.2
Seggewiss, R.3
Bokemeyer, C.4
Fettes, P.5
Klinger, M.6
Vieser, E.7
Ruettinger, D.8
Kaubitzsch, S.9
Wolf, M.10
-
28
-
-
84867563910
-
Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials
-
Turriziani M., Fantini M., Benvenuto M., Izzi V., Masuelli L., Sacchetti P., Modesti A., Bei R. Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials. Recent Pat Anticancer Drug Discov 2012, 7:265-296.
-
(2012)
Recent Pat Anticancer Drug Discov
, vol.7
, pp. 265-296
-
-
Turriziani, M.1
Fantini, M.2
Benvenuto, M.3
Izzi, V.4
Masuelli, L.5
Sacchetti, P.6
Modesti, A.7
Bei, R.8
-
29
-
-
84861786167
-
Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis
-
Dallas M.R., Liu G., Chen W.-C., Thomas S.N., Wirtz D., Huso D.L., Konstantopoulos K. Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis. FASEB J 2012, 26:2648-2656.
-
(2012)
FASEB J
, vol.26
, pp. 2648-2656
-
-
Dallas, M.R.1
Liu, G.2
Chen, W.-C.3
Thomas, S.N.4
Wirtz, D.5
Huso, D.L.6
Konstantopoulos, K.7
-
30
-
-
84860515259
-
The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA
-
Peng L., Oberst M.D., Huang J., Brohawn P., Morehouse C., Lekstrom K., Baeuerle P.A., Wu H., Yao Y., Coats S.R., et al. The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA. PLoS ONE 2012, 7:e36412.
-
(2012)
PLoS ONE
, vol.7
-
-
Peng, L.1
Oberst, M.D.2
Huang, J.3
Brohawn, P.4
Morehouse, C.5
Lekstrom, K.6
Baeuerle, P.A.7
Wu, H.8
Yao, Y.9
Coats, S.R.10
-
31
-
-
67449097665
-
Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA
-
Lutterbuese R., Raum T., Kischel R., Lutterbuese P., Schlereth B., Schaller E., Mangold S., Rau D., Meier P., Kiener P.A., et al. Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA. J Immunother 2009, 32:341-352.
-
(2009)
J Immunother
, vol.32
, pp. 341-352
-
-
Lutterbuese, R.1
Raum, T.2
Kischel, R.3
Lutterbuese, P.4
Schlereth, B.5
Schaller, E.6
Mangold, S.7
Rau, D.8
Meier, P.9
Kiener, P.A.10
-
32
-
-
74249122446
-
Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
-
Osada T., Hsu D., Hammond S., Hobeika A., Devi G., Clay T.M., Lyerly H.K., Morse M.A. Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody. Br J Cancer 2010, 102:124-133.
-
(2010)
Br J Cancer
, vol.102
, pp. 124-133
-
-
Osada, T.1
Hsu, D.2
Hammond, S.3
Hobeika, A.4
Devi, G.5
Clay, T.M.6
Lyerly, H.K.7
Morse, M.A.8
-
34
-
-
84871360414
-
Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens
-
Friedrich M., Raum T., Lutterbuese R., Voelkel M., Deegen P., Rau D., Kischel R., Hoffmann P., Brandl C., Schuhmacher J., et al. Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens. Mol Cancer Ther 2012, 11:2664-2673.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2664-2673
-
-
Friedrich, M.1
Raum, T.2
Lutterbuese, R.3
Voelkel, M.4
Deegen, P.5
Rau, D.6
Kischel, R.7
Hoffmann, P.8
Brandl, C.9
Schuhmacher, J.10
-
35
-
-
84892675951
-
Abstract 3526: subcutaneous administration of PSMA/CD3-bispecific BiTE antibody MT112/BAY 2010112 leads to complete remission of human prostate cancer xenografts in mice
-
Friedrich M., Deegen P., Voelkel M., Wahl J.J.S., Steinkem W., Zopf D., Harris R.B., Baeuerle P.A., Kufer P., et al. Abstract 3526: subcutaneous administration of PSMA/CD3-bispecific BiTE antibody MT112/BAY 2010112 leads to complete remission of human prostate cancer xenografts in mice. Cancer Res 2012, 72(Suppl 1).
-
(2012)
Cancer Res
, vol.72
, Issue.SUPPL 1
-
-
Friedrich, M.1
Deegen, P.2
Voelkel, M.3
Wahl, J.J.S.4
Steinkem, W.5
Zopf, D.6
Harris, R.B.7
Baeuerle, P.A.8
Kufer, P.9
-
36
-
-
84876116790
-
T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE[reg] antibody construct
-
Aigner M., Feulner J., Schaffer S., Kischel R., Kufer P., Schneider K., Henn A., Rattel B., Friedrich M., Baeuerle P.A., et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE[reg] antibody construct. Leukemia 2012, 10.1038/leu.2012.341.
-
(2012)
Leukemia
-
-
Aigner, M.1
Feulner, J.2
Schaffer, S.3
Kischel, R.4
Kufer, P.5
Schneider, K.6
Henn, A.7
Rattel, B.8
Friedrich, M.9
Baeuerle, P.A.10
-
37
-
-
77955433583
-
T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells
-
Lutterbuese R., Raum T., Kischel R., Hoffmann P., Mangold S., Rattel B., Friedrich M., Thomas O., Lorenczewski G., Rau D., et al. T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells. Proc Natl Acad Sci U S A 2010, 107:12605-12610.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12605-12610
-
-
Lutterbuese, R.1
Raum, T.2
Kischel, R.3
Hoffmann, P.4
Mangold, S.5
Rattel, B.6
Friedrich, M.7
Thomas, O.8
Lorenczewski, G.9
Rau, D.10
-
38
-
-
77953228970
-
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
-
Bluemel C., Hausmann S., Fluhr P., Sriskandarajah M., Stallcup W.B., Baeuerle P.A., Kufer P. Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen. Cancer Immunol Immunother 2010, 59:1197-1209.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1197-1209
-
-
Bluemel, C.1
Hausmann, S.2
Fluhr, P.3
Sriskandarajah, M.4
Stallcup, W.B.5
Baeuerle, P.A.6
Kufer, P.7
-
39
-
-
80052971289
-
Redirected lysis of human melanoma cells by a MCSP/CD3-bispecific BiTE antibody that engages patient-derived T cells
-
Torisu-Itakura H., Schoellhammer H.F., Sim M.S., Irie R.F., Hausmann S., Raum T., Baeuerle P.A., Morton D.L. Redirected lysis of human melanoma cells by a MCSP/CD3-bispecific BiTE antibody that engages patient-derived T cells. J Immunother 2011, 34:597-605.
-
(2011)
J Immunother
, vol.34
, pp. 597-605
-
-
Torisu-Itakura, H.1
Schoellhammer, H.F.2
Sim, M.S.3
Irie, R.F.4
Hausmann, S.5
Raum, T.6
Baeuerle, P.A.7
Morton, D.L.8
-
41
-
-
84858759304
-
Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer
-
Baeuerle P.A., Itin C. Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer. Curr Pharm Biotechnol 2012, 13:1399-1408.
-
(2012)
Curr Pharm Biotechnol
, vol.13
, pp. 1399-1408
-
-
Baeuerle, P.A.1
Itin, C.2
-
42
-
-
84863132749
-
New gene-immunotherapy combining TRAIL-lymphocytes and EpCAM×CD3 bispecific antibody for tumor targeting
-
Groth A., Salnikov A.V., Ottinger S., Gladkich J., Liu L., Kallifatidis G., Salnikova O., Ryschich E., Giese N., Giese T., et al. New gene-immunotherapy combining TRAIL-lymphocytes and EpCAM×CD3 bispecific antibody for tumor targeting. Clin Cancer Res 2012, 18:1028-1038.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1028-1038
-
-
Groth, A.1
Salnikov, A.V.2
Ottinger, S.3
Gladkich, J.4
Liu, L.5
Kallifatidis, G.6
Salnikova, O.7
Ryschich, E.8
Giese, N.9
Giese, T.10
-
43
-
-
84866159579
-
Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells
-
Feldmann A., Arndt C., Töpfer K., Stamova S., Krone F., Cartellieri M., Koristka S., Michalk I., Lindemann D., Schmitz M., et al. Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells. J Immunol 2012, 189:3249-3259.
-
(2012)
J Immunol
, vol.189
, pp. 3249-3259
-
-
Feldmann, A.1
Arndt, C.2
Töpfer, K.3
Stamova, S.4
Krone, F.5
Cartellieri, M.6
Koristka, S.7
Michalk, I.8
Lindemann, D.9
Schmitz, M.10
-
44
-
-
79952380566
-
Effective targeting of prostate cancer by lymphocytes redirected by a PSMA×CD3 bispecific single-chain diabody
-
Fortmüller K., Alt K., Gierschner D., Wolf P., Baum V., Freudenberg N., Wetterauer U., Elsässer-Beile U., Bühler P. Effective targeting of prostate cancer by lymphocytes redirected by a PSMA×CD3 bispecific single-chain diabody. Prostate 2011, 71:588-596.
-
(2011)
Prostate
, vol.71
, pp. 588-596
-
-
Fortmüller, K.1
Alt, K.2
Gierschner, D.3
Wolf, P.4
Baum, V.5
Freudenberg, N.6
Wetterauer, U.7
Elsässer-Beile, U.8
Bühler, P.9
-
45
-
-
84892672017
-
319 anti-PSMA×anti-CD3 bispecific antibody efficiently redirects T cell cytotoxicity in castrate-resistant prostate cancer models
-
Sewell T., Hernandez-Hoyos G., Chenault R.A., Wiens J., Kumer J., Natarajan S., McMahan C.J., Algate P.A., Blankenship J.W. 319 anti-PSMA×anti-CD3 bispecific antibody efficiently redirects T cell cytotoxicity in castrate-resistant prostate cancer models. Eur J Cancer 2012, 48(Suppl 6):98.
-
(2012)
Eur J Cancer
, vol.48
, Issue.SUPPL 6
, pp. 98
-
-
Sewell, T.1
Hernandez-Hoyos, G.2
Chenault, R.A.3
Wiens, J.4
Kumer, J.5
Natarajan, S.6
McMahan, C.J.7
Algate, P.A.8
Blankenship, J.W.9
-
46
-
-
84871546145
-
Antitumor activities of PSMA×CD3 diabodies by redirected T-cell lysis of prostate cancer cells
-
Baum V., Bühler P., Gierschner D., Herchenbach D., Fiala G.J., Schamel W.W.A., Wolf P., Elsässer-Beile U. Antitumor activities of PSMA×CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy 2013, 5:27-38.
-
(2013)
Immunotherapy
, vol.5
, pp. 27-38
-
-
Baum, V.1
Bühler, P.2
Gierschner, D.3
Herchenbach, D.4
Fiala, G.J.5
Schamel, W.W.A.6
Wolf, P.7
Elsässer-Beile, U.8
-
47
-
-
84862507314
-
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells
-
Yamamoto K., Trad A., Baumgart A., Huske L., Lorenzen I., Chalaris A., Grotzinger J., Dechow T., Scheller J., Rose-John S. A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells. Biochem J 2012, 445:135-144.
-
(2012)
Biochem J
, vol.445
, pp. 135-144
-
-
Yamamoto, K.1
Trad, A.2
Baumgart, A.3
Huske, L.4
Lorenzen, I.5
Chalaris, A.6
Grotzinger, J.7
Dechow, T.8
Scheller, J.9
Rose-John, S.10
-
48
-
-
79958041608
-
Bispecific antibodies engage T cells for antitumor immunotherapy
-
Choi B.D., Cai M., Bigner D.D., Mehta A.I., Kuan C.T., Sampson J.H. Bispecific antibodies engage T cells for antitumor immunotherapy. Expert Opin Biol Ther 2011, 11:843-853.
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 843-853
-
-
Choi, B.D.1
Cai, M.2
Bigner, D.D.3
Mehta, A.I.4
Kuan, C.T.5
Sampson, J.H.6
-
49
-
-
84866996937
-
Engineering a CD123×CD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
-
Kuo S.-R., Wong L., Liu J.-S. Engineering a CD123×CD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Eng Des Select 2012, 25:561-570.
-
(2012)
Protein Eng Des Select
, vol.25
, pp. 561-570
-
-
Kuo, S.-R.1
Wong, L.2
Liu, J.-S.3
-
50
-
-
84867580896
-
T and NK cells of B cell NHL patients exert cytotoxicity against lymphoma cells following binding of bispecific tetravalent antibody CD19×CD3 or CD19×CD16
-
Portner L.M., Schonberg K., Hejazi M., Brunnert D., Neumann F., Galonska L., Reusch U., Little M., Haas R., Uhrberg M. T and NK cells of B cell NHL patients exert cytotoxicity against lymphoma cells following binding of bispecific tetravalent antibody CD19×CD3 or CD19×CD16. Cancer Immunol Immunother 2012, 61:1869-1875.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1869-1875
-
-
Portner, L.M.1
Schonberg, K.2
Hejazi, M.3
Brunnert, D.4
Neumann, F.5
Galonska, L.6
Reusch, U.7
Little, M.8
Haas, R.9
Uhrberg, M.10
-
51
-
-
79955970356
-
Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
-
Moore P.A., Zhang W., Rainey G.J., Burke S., Li H., Huang L., Gorlatov S., Veri M.C., Aggarwal S., Yang Y., et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood 2011, 117:4542-4551.
-
(2011)
Blood
, vol.117
, pp. 4542-4551
-
-
Moore, P.A.1
Zhang, W.2
Rainey, G.J.3
Burke, S.4
Li, H.5
Huang, L.6
Gorlatov, S.7
Veri, M.C.8
Aggarwal, S.9
Yang, Y.10
-
52
-
-
84865235085
-
Chemically programmed bispecific antibodies that recruit and activate T cells
-
Cui H., Thomas J.D., Burke T.R., Rader C. Chemically programmed bispecific antibodies that recruit and activate T cells. J Biol Chem 2012, 287:28206-28214.
-
(2012)
J Biol Chem
, vol.287
, pp. 28206-28214
-
-
Cui, H.1
Thomas, J.D.2
Burke, T.R.3
Rader, C.4
-
53
-
-
84862025335
-
Monoclonal TCR-redirected tumor cell killing
-
Liddy N., Bossi G., Adams K.J., Lissina A., Mahon T.M., Hassan N.J., Gavarret J., Bianchi F.C., Pumphrey N.J., Ladell K., et al. Monoclonal TCR-redirected tumor cell killing. Nat Med 2012, 18:980-987.
-
(2012)
Nat Med
, vol.18
, pp. 980-987
-
-
Liddy, N.1
Bossi, G.2
Adams, K.J.3
Lissina, A.4
Mahon, T.M.5
Hassan, N.J.6
Gavarret, J.7
Bianchi, F.C.8
Pumphrey, N.J.9
Ladell, K.10
-
54
-
-
84877880167
-
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors
-
McCormack E., Adams K., Hassan N., Kotian A., Lissin N., Sami M., Mujić M., Osdal T., Gjertsen B., Baker D., et al. Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. Cancer Immunol Immunother 2012, 1-13.
-
(2012)
Cancer Immunol Immunother
, pp. 1-13
-
-
McCormack, E.1
Adams, K.2
Hassan, N.3
Kotian, A.4
Lissin, N.5
Sami, M.6
Mujić, M.7
Osdal, T.8
Gjertsen, B.9
Baker, D.10
-
55
-
-
84855769575
-
Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies
-
Marr L.A., Gilham D.E., Campbell J.D.M., Fraser A.R. Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clin Exp Immunol 2012, 167:216-225.
-
(2012)
Clin Exp Immunol
, vol.167
, pp. 216-225
-
-
Marr, L.A.1
Gilham, D.E.2
Campbell, J.D.M.3
Fraser, A.R.4
-
56
-
-
84870337394
-
Improving the efficacy and safety of engineered T cell therapy for cancer
-
Shi H., Liu L., Wang Z. Improving the efficacy and safety of engineered T cell therapy for cancer. Cancer Lett 2013, 328:191-197.
-
(2013)
Cancer Lett
, vol.328
, pp. 191-197
-
-
Shi, H.1
Liu, L.2
Wang, Z.3
-
57
-
-
84863085396
-
CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe
-
Gilham D.E., Debets R., Pule M., Hawkins R.E., Abken H. CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. Trends Mol Med 2012, 18:377-384.
-
(2012)
Trends Mol Med
, vol.18
, pp. 377-384
-
-
Gilham, D.E.1
Debets, R.2
Pule, M.3
Hawkins, R.E.4
Abken, H.5
-
58
-
-
84878921225
-
A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)
-
Stone J.D., Aggen D.H., Schietinger A., Schreiber H., Kranz D.M. A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunol 2012, 1:863-873.
-
(2012)
Oncoimmunol
, vol.1
, pp. 863-873
-
-
Stone, J.D.1
Aggen, D.H.2
Schietinger, A.3
Schreiber, H.4
Kranz, D.M.5
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