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Volumn 17, Issue 3, 2013, Pages 385-392

Targeting T cells to tumor cells using bispecific antibodies

Author keywords

[No Author keywords available]

Indexed keywords

AMG 211; AMG 212; ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; BLINATUMOMAB; CARCINOEMBRYONIC ANTIGEN; CATUMAXOMAB; CD19 ANTIGEN; CD69 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; RECOMBINANT ANTIBODY; SOLITOMAB; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84878931351     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2013.03.029     Document Type: Review
Times cited : (152)

References (58)
  • 2
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman W.H., Pagès F., Sautès-Fridman C., Galon J The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012, 12:298-306.
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pagès, F.2    Sautès-Fridman, C.3    Galon, J.4
  • 3
    • 84860220430 scopus 로고    scopus 로고
    • Tumor-dependent down-regulation of the ζ-chain in T-cells is detectable in early breast cancer and correlates with immune cell function
    • Boniface J.D., Poschke I., Mao Y., Kiessling R. Tumor-dependent down-regulation of the ζ-chain in T-cells is detectable in early breast cancer and correlates with immune cell function. Int J Cancer 2012, 131:129-139.
    • (2012) Int J Cancer , vol.131 , pp. 129-139
    • Boniface, J.D.1    Poschke, I.2    Mao, Y.3    Kiessling, R.4
  • 4
    • 79952281795 scopus 로고    scopus 로고
    • Improving cancer immunotherapy by targeting tumor-induced immune suppression
    • Stewart T., Smyth M. Improving cancer immunotherapy by targeting tumor-induced immune suppression. Cancer Metast Rev 2011, 30:125-140.
    • (2011) Cancer Metast Rev , vol.30 , pp. 125-140
    • Stewart, T.1    Smyth, M.2
  • 5
    • 84862135169 scopus 로고    scopus 로고
    • What are regulatory T cells (Treg) regulating in cancer and why?
    • Whiteside T.L. What are regulatory T cells (Treg) regulating in cancer and why?. Semin Cancer Biol 2012, 22:327-334.
    • (2012) Semin Cancer Biol , vol.22 , pp. 327-334
    • Whiteside, T.L.1
  • 6
    • 84869380716 scopus 로고    scopus 로고
    • Immunology beats cancer: a blueprint for successful translation
    • Pardoll D.M. Immunology beats cancer: a blueprint for successful translation. Nat Immunol 2012, 13:1129-1132.
    • (2012) Nat Immunol , vol.13 , pp. 1129-1132
    • Pardoll, D.M.1
  • 7
    • 84872668649 scopus 로고    scopus 로고
    • Bispecific T cell engager for cancer therapy
    • Springer-Verlag, R.E. Kontermann (Ed.)
    • Baeuerle P.A., Zugmaier G., Ruttinger D. Bispecific T cell engager for cancer therapy. Bispecific Antibodies 2011, 273-287. Springer-Verlag. R.E. Kontermann (Ed.).
    • (2011) Bispecific Antibodies , pp. 273-287
    • Baeuerle, P.A.1    Zugmaier, G.2    Ruttinger, D.3
  • 8
    • 84862251353 scopus 로고    scopus 로고
    • Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on
    • Riethmuller G. Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on. Cancer Immun 2012, 12:12.
    • (2012) Cancer Immun , vol.12 , pp. 12
    • Riethmuller, G.1
  • 13
    • 84862634261 scopus 로고    scopus 로고
    • Blinatumomab (CD3/CD19 BITE antibody) results in a high response rate in patients with relapsed non-Hodgkin lymphoma (NHL) including MCL and DLBCL
    • (abstract 068)
    • Goebeler M., Viardot A., Noppeney R., Krause S., Mackensen A., Rupertus K., Kanz L., Knop S., Topp M., Scheele J., et al. Blinatumomab (CD3/CD19 BITE antibody) results in a high response rate in patients with relapsed non-Hodgkin lymphoma (NHL) including MCL and DLBCL. Ann Oncol (ICML) 2011, 22:105. (abstract 068).
    • (2011) Ann Oncol (ICML) , vol.22 , pp. 105
    • Goebeler, M.1    Viardot, A.2    Noppeney, R.3    Krause, S.4    Mackensen, A.5    Rupertus, K.6    Kanz, L.7    Knop, S.8    Topp, M.9    Scheele, J.10
  • 15
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-Cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp M.S., Kufer P., Gökbuget N., Goebeler M., Klinger M., Neumann S., Horst H.-A., Raff T., Viardot A., Schmid M., et al. Targeted therapy with the T-Cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011, 29:2493-2498.
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gökbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6    Horst, H.-A.7    Raff, T.8    Viardot, A.9    Schmid, M.10
  • 16
    • 84876272598 scopus 로고    scopus 로고
    • Anti-CD19 BiTE blinatumomab induces high complete remission rate and prolongs overall survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL)
    • Topp M.S., Goekbuget N., Zugmaier G., Viardot A., Stelljes M., Neumann S., Horst H.A., Reichle A., Marks R., Faul C., et al. Anti-CD19 BiTE blinatumomab induces high complete remission rate and prolongs overall survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). ASH Annu Meet Abst 2012, 120:670.
    • (2012) ASH Annu Meet Abst , vol.120 , pp. 670
    • Topp, M.S.1    Goekbuget, N.2    Zugmaier, G.3    Viardot, A.4    Stelljes, M.5    Neumann, S.6    Horst, H.A.7    Reichle, A.8    Marks, R.9    Faul, C.10
  • 17
    • 84863522243 scopus 로고    scopus 로고
    • Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
    • Klinger M., Brandl C., Zugmaier G., Hijazi Y., Bargou R.C., Topp M.S., Gokbuget N., Neumann S., Goebeler M., Viardot A., et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 2012, 119:6226-6233.
    • (2012) Blood , vol.119 , pp. 6226-6233
    • Klinger, M.1    Brandl, C.2    Zugmaier, G.3    Hijazi, Y.4    Bargou, R.C.5    Topp, M.S.6    Gokbuget, N.7    Neumann, S.8    Goebeler, M.9    Viardot, A.10
  • 18
    • 84855952224 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    • Patriarca C., Macchi R.M., Marschner A.K., Mellstedt H. Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev 2012, 38:68-75.
    • (2012) Cancer Treat Rev , vol.38 , pp. 68-75
    • Patriarca, C.1    Macchi, R.M.2    Marschner, A.K.3    Mellstedt, H.4
  • 22
    • 84856007019 scopus 로고    scopus 로고
    • EpCAM/CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells
    • Cioffi M., Dorado J., Baeuerle P.A., Heeschen C. EpCAM/CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res 2012, 18:465-474.
    • (2012) Clin Cancer Res , vol.18 , pp. 465-474
    • Cioffi, M.1    Dorado, J.2    Baeuerle, P.A.3    Heeschen, C.4
  • 24
    • 67651165121 scopus 로고    scopus 로고
    • Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release
    • Amann M., D'Argouges S., Lorenczewski G., Brischwein K., Kischel R., Lutterbuese R., Mangold S., Rau D., Volkland J., Pflanz S., et al. Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release. J Immunother 2009, 32:452-464.
    • (2009) J Immunother , vol.32 , pp. 452-464
    • Amann, M.1    D'Argouges, S.2    Lorenczewski, G.3    Brischwein, K.4    Kischel, R.5    Lutterbuese, R.6    Mangold, S.7    Rau, D.8    Volkland, J.9    Pflanz, S.10
  • 30
    • 84860515259 scopus 로고    scopus 로고
    • The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA
    • Peng L., Oberst M.D., Huang J., Brohawn P., Morehouse C., Lekstrom K., Baeuerle P.A., Wu H., Yao Y., Coats S.R., et al. The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA. PLoS ONE 2012, 7:e36412.
    • (2012) PLoS ONE , vol.7
    • Peng, L.1    Oberst, M.D.2    Huang, J.3    Brohawn, P.4    Morehouse, C.5    Lekstrom, K.6    Baeuerle, P.A.7    Wu, H.8    Yao, Y.9    Coats, S.R.10
  • 32
    • 74249122446 scopus 로고    scopus 로고
    • Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
    • Osada T., Hsu D., Hammond S., Hobeika A., Devi G., Clay T.M., Lyerly H.K., Morse M.A. Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody. Br J Cancer 2010, 102:124-133.
    • (2010) Br J Cancer , vol.102 , pp. 124-133
    • Osada, T.1    Hsu, D.2    Hammond, S.3    Hobeika, A.4    Devi, G.5    Clay, T.M.6    Lyerly, H.K.7    Morse, M.A.8
  • 34
    • 84871360414 scopus 로고    scopus 로고
    • Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens
    • Friedrich M., Raum T., Lutterbuese R., Voelkel M., Deegen P., Rau D., Kischel R., Hoffmann P., Brandl C., Schuhmacher J., et al. Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens. Mol Cancer Ther 2012, 11:2664-2673.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2664-2673
    • Friedrich, M.1    Raum, T.2    Lutterbuese, R.3    Voelkel, M.4    Deegen, P.5    Rau, D.6    Kischel, R.7    Hoffmann, P.8    Brandl, C.9    Schuhmacher, J.10
  • 35
    • 84892675951 scopus 로고    scopus 로고
    • Abstract 3526: subcutaneous administration of PSMA/CD3-bispecific BiTE antibody MT112/BAY 2010112 leads to complete remission of human prostate cancer xenografts in mice
    • Friedrich M., Deegen P., Voelkel M., Wahl J.J.S., Steinkem W., Zopf D., Harris R.B., Baeuerle P.A., Kufer P., et al. Abstract 3526: subcutaneous administration of PSMA/CD3-bispecific BiTE antibody MT112/BAY 2010112 leads to complete remission of human prostate cancer xenografts in mice. Cancer Res 2012, 72(Suppl 1).
    • (2012) Cancer Res , vol.72 , Issue.SUPPL 1
    • Friedrich, M.1    Deegen, P.2    Voelkel, M.3    Wahl, J.J.S.4    Steinkem, W.5    Zopf, D.6    Harris, R.B.7    Baeuerle, P.A.8    Kufer, P.9
  • 36
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE[reg] antibody construct
    • Aigner M., Feulner J., Schaffer S., Kischel R., Kufer P., Schneider K., Henn A., Rattel B., Friedrich M., Baeuerle P.A., et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE[reg] antibody construct. Leukemia 2012, 10.1038/leu.2012.341.
    • (2012) Leukemia
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3    Kischel, R.4    Kufer, P.5    Schneider, K.6    Henn, A.7    Rattel, B.8    Friedrich, M.9    Baeuerle, P.A.10
  • 38
    • 77953228970 scopus 로고    scopus 로고
    • Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
    • Bluemel C., Hausmann S., Fluhr P., Sriskandarajah M., Stallcup W.B., Baeuerle P.A., Kufer P. Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen. Cancer Immunol Immunother 2010, 59:1197-1209.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1197-1209
    • Bluemel, C.1    Hausmann, S.2    Fluhr, P.3    Sriskandarajah, M.4    Stallcup, W.B.5    Baeuerle, P.A.6    Kufer, P.7
  • 41
    • 84858759304 scopus 로고    scopus 로고
    • Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer
    • Baeuerle P.A., Itin C. Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer. Curr Pharm Biotechnol 2012, 13:1399-1408.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 1399-1408
    • Baeuerle, P.A.1    Itin, C.2
  • 43
    • 84866159579 scopus 로고    scopus 로고
    • Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells
    • Feldmann A., Arndt C., Töpfer K., Stamova S., Krone F., Cartellieri M., Koristka S., Michalk I., Lindemann D., Schmitz M., et al. Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells. J Immunol 2012, 189:3249-3259.
    • (2012) J Immunol , vol.189 , pp. 3249-3259
    • Feldmann, A.1    Arndt, C.2    Töpfer, K.3    Stamova, S.4    Krone, F.5    Cartellieri, M.6    Koristka, S.7    Michalk, I.8    Lindemann, D.9    Schmitz, M.10
  • 49
    • 84866996937 scopus 로고    scopus 로고
    • Engineering a CD123×CD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
    • Kuo S.-R., Wong L., Liu J.-S. Engineering a CD123×CD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Eng Des Select 2012, 25:561-570.
    • (2012) Protein Eng Des Select , vol.25 , pp. 561-570
    • Kuo, S.-R.1    Wong, L.2    Liu, J.-S.3
  • 51
    • 79955970356 scopus 로고    scopus 로고
    • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
    • Moore P.A., Zhang W., Rainey G.J., Burke S., Li H., Huang L., Gorlatov S., Veri M.C., Aggarwal S., Yang Y., et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood 2011, 117:4542-4551.
    • (2011) Blood , vol.117 , pp. 4542-4551
    • Moore, P.A.1    Zhang, W.2    Rainey, G.J.3    Burke, S.4    Li, H.5    Huang, L.6    Gorlatov, S.7    Veri, M.C.8    Aggarwal, S.9    Yang, Y.10
  • 52
    • 84865235085 scopus 로고    scopus 로고
    • Chemically programmed bispecific antibodies that recruit and activate T cells
    • Cui H., Thomas J.D., Burke T.R., Rader C. Chemically programmed bispecific antibodies that recruit and activate T cells. J Biol Chem 2012, 287:28206-28214.
    • (2012) J Biol Chem , vol.287 , pp. 28206-28214
    • Cui, H.1    Thomas, J.D.2    Burke, T.R.3    Rader, C.4
  • 55
    • 84855769575 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies
    • Marr L.A., Gilham D.E., Campbell J.D.M., Fraser A.R. Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clin Exp Immunol 2012, 167:216-225.
    • (2012) Clin Exp Immunol , vol.167 , pp. 216-225
    • Marr, L.A.1    Gilham, D.E.2    Campbell, J.D.M.3    Fraser, A.R.4
  • 56
    • 84870337394 scopus 로고    scopus 로고
    • Improving the efficacy and safety of engineered T cell therapy for cancer
    • Shi H., Liu L., Wang Z. Improving the efficacy and safety of engineered T cell therapy for cancer. Cancer Lett 2013, 328:191-197.
    • (2013) Cancer Lett , vol.328 , pp. 191-197
    • Shi, H.1    Liu, L.2    Wang, Z.3
  • 57
    • 84863085396 scopus 로고    scopus 로고
    • CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe
    • Gilham D.E., Debets R., Pule M., Hawkins R.E., Abken H. CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. Trends Mol Med 2012, 18:377-384.
    • (2012) Trends Mol Med , vol.18 , pp. 377-384
    • Gilham, D.E.1    Debets, R.2    Pule, M.3    Hawkins, R.E.4    Abken, H.5
  • 58
    • 84878921225 scopus 로고    scopus 로고
    • A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)
    • Stone J.D., Aggen D.H., Schietinger A., Schreiber H., Kranz D.M. A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunol 2012, 1:863-873.
    • (2012) Oncoimmunol , vol.1 , pp. 863-873
    • Stone, J.D.1    Aggen, D.H.2    Schietinger, A.3    Schreiber, H.4    Kranz, D.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.