Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes

Journal of Applied Toxicology

Volumn 36, Issue 6, 2016, Pages 777-789

  Weatherly, Lisa M ^a,b   Shim, Juyoung ^b   Hashmi, Hina N ^b   Kennedy, Rachel H ^a,b   Hess, Samuel T ^a,c   Gosse, Julie A ^a,b  

^a Graduate School of Biomedical Sciences   (United States)

^b UNIVERSITY OF MAINE   (United States)

^c NONE   (United States)

Author keywords

HMC 1.2; Mast cell; Mitochondrial uncoupler; RBL 2H3; Triclosan; Triclosan methyl

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA N ACETYLHEXOSAMINIDASE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; GALACTOSE; GLUCOSE; METHYL GROUP; METHYLTRICLOSAN; OXYGEN; PROTON IONOPHORE; THAPSIGARGIN; TRICLOSAN; ANTINEOPLASTIC AGENT; CARCINOGEN; TOPICAL ANTIINFECTIVE AGENT; UNCOUPLING PROTEIN;

3T3 CELL LINE; ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KERATINOCYTE; MAST CELL; MAST CELL DEGRANULATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; CELL SURVIVAL; DEGRANULATION; DRUG EFFECTS; IMMUNOLOGY; KINETICS; METABOLISM; MOUSE; NIH 3T3 CELL LINE; OXIDATIVE PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTICARCINOGENIC AGENTS; CARCINOGENS; CELL DEGRANULATION; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; HUMANS; KERATINOCYTES; KINETICS; MAST CELLS; MICE; MITOCHONDRIA; NIH 3T3 CELLS; OXIDATIVE PHOSPHORYLATION; RATS; THAPSIGARGIN; TRICLOSAN; UNCOUPLING AGENTS;

EID: 84937703768     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3209     Document Type: Article

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